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2014 | OriginalPaper | Chapter

Parallel Biological In Silico Simulation

Authors : Patrick Amar, Muriel Baillieul, Dominique Barth, Bertrand LeCun, Franck Quessette, Sandrine Vial

Published in: Information Sciences and Systems 2014

Publisher: Springer International Publishing

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Abstract

It is crucial to understand how biological systems work, in particular the metabolic pathways, if we want to be able to understand diseases. One of the author has developed HSIM, a simulator dedicated to the biochemical simulation of the reactions inside the compartments of a virtual cell. Another author is the leader in the development of bobpp a high level parallelization framework. In this article, we propose an important improvement of bobpp in order to run HSIM in parallel. This will allow us to simulate more complex models, involving more chemical species and reactions, leading to more realistic results using a smaller amount of computing time.

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Footnotes
1
This software is freely available at http://​www.​lri.​fr/​~pa/​Hsim.
 
Literature
1.
go back to reference P. Amar, G. Bernot, V. Norris, Hsim: a simualtion programme to study large assemblies of proteins. J. Biol. Phys. Chem. 4(2), 50–63 (2004) P. Amar, G. Bernot, V. Norris, Hsim: a simualtion programme to study large assemblies of proteins. J. Biol. Phys. Chem. 4(2), 50–63 (2004)
2.
go back to reference P. Amar, L. Paulevé, Hsim: an hybrid stochastic simulation system for systems biology. in: the Third International Conference on Static Analysis and Systems Biology (2012) P. Amar, L. Paulevé, Hsim: an hybrid stochastic simulation system for systems biology. in: the Third International Conference on Static Analysis and Systems Biology (2012)
3.
go back to reference F. Galea, B. Le Cun, Bob++ : a framework for exact combinatorial optimization methods on parallel machines. in: International Conference High Performance Computing & Simulation 2007 (HPCS’07), pp. 779–785 (2007) F. Galea, B. Le Cun, Bob++ : a framework for exact combinatorial optimization methods on parallel machines. in: International Conference High Performance Computing & Simulation 2007 (HPCS’07), pp. 779–785 (2007)
4.
go back to reference T. Gautier, J.V.F. Lima, N. Maillard, B. Raffin, XKaapi: a Runtime System for Data-Flow Task Programming on Heterogeneous Architectures. in: Proc. of the 27-th IEEE International Parallel and Distributed Processing Symposium (IPDPS). Boston, USA (2013) T. Gautier, J.V.F. Lima, N. Maillard, B. Raffin, XKaapi: a Runtime System for Data-Flow Task Programming on Heterogeneous Architectures. in: Proc. of the 27-th IEEE International Parallel and Distributed Processing Symposium (IPDPS). Boston, USA (2013)
5.
go back to reference L. Kale, B. Ramkunar, A. Sinha, A. Gursoy, The charm parallel programming language and system. Tech. Rep. 2, 1–27 (1994) L. Kale, B. Ramkunar, A. Sinha, A. Gursoy, The charm parallel programming language and system. Tech. Rep. 2, 1–27 (1994)
6.
go back to reference T. Crainic, B. Le Cun, C. Roucairol, Parallel Branch and Bound Algorithms (Wiley, USA, 2006), pp. 1–28 T. Crainic, B. Le Cun, C. Roucairol, Parallel Branch and Bound Algorithms (Wiley, USA, 2006), pp. 1–28
7.
go back to reference T. Menouer, B. Le Cun, P. Vander-Swalmen, Solving combinatorial problems on hpc with bobpp, WolfHPC in SuperComputing (2012) T. Menouer, B. Le Cun, P. Vander-Swalmen, Solving combinatorial problems on hpc with bobpp, WolfHPC in SuperComputing (2012)
8.
go back to reference M.J. Saltzman, Coin-or, Programming Languages and Systems in Computational Economics and Finance, An Open Source Library for Optimization (Springer, Boston, 2002) M.J. Saltzman, Coin-or, Programming Languages and Systems in Computational Economics and Finance, An Open Source Library for Optimization (Springer, Boston, 2002)
9.
go back to reference J. Eckstein, C.A. Phillips, W.E. Hart, PEBBL 1.0 User Guide. RRR 19–2006, RUTCOR (2006) J. Eckstein, C.A. Phillips, W.E. Hart, PEBBL 1.0 User Guide. RRR 19–2006, RUTCOR (2006)
10.
go back to reference T. Ralphs, L. Ladányi, M. Saltzman, A Library Hierarchy for Implementing Scalable Parallel Search algorithms. J. Supercomp. 28(2), 215–234 (2004)CrossRefMATH T. Ralphs, L. Ladányi, M. Saltzman, A Library Hierarchy for Implementing Scalable Parallel Search algorithms. J. Supercomp. 28(2), 215–234 (2004)CrossRefMATH
11.
go back to reference Y. Xu, T. Ralphs, L. Ladányi, M. Saltzman, ALPS: A Framework for Implementing Parallel Search Algorithms. in: Proc. of the Ninth INFORMS Computing Society Conference (2005) Y. Xu, T. Ralphs, L. Ladányi, M. Saltzman, ALPS: A Framework for Implementing Parallel Search Algorithms. in: Proc. of the Ninth INFORMS Computing Society Conference (2005)
12.
go back to reference V.D. Cung, S. Dowaji, B. Le C, T. Mautor, C. Roucairol, Concurrent data structures and load balancing strategies for parallel branch-and-bound/a\(^{*}\) algorithms. in: III Annual Implementation Challenge Workshop, DIMACS. New Brunswick, USA (1994) V.D. Cung, S. Dowaji, B. Le C, T. Mautor, C. Roucairol, Concurrent data structures and load balancing strategies for parallel branch-and-bound/a\(^{*}\) algorithms. in: III Annual Implementation Challenge Workshop, DIMACS. New Brunswick, USA (1994)
13.
go back to reference B. Le Cun, C. Roucairol, the PNN team: Bob : a unified platform for implementing branch-and-bound like algorithms. RR 95/16, Laboratoire PR iSM, Université de Versailles - Saint Quentin en Yvelines (1995) B. Le Cun, C. Roucairol, the PNN team: Bob : a unified platform for implementing branch-and-bound like algorithms. RR 95/16, Laboratoire PR iSM, Université de Versailles - Saint Quentin en Yvelines (1995)
Metadata
Title
Parallel Biological In Silico Simulation
Authors
Patrick Amar
Muriel Baillieul
Dominique Barth
Bertrand LeCun
Franck Quessette
Sandrine Vial
Copyright Year
2014
DOI
https://doi.org/10.1007/978-3-319-09465-6_40

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