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2021 | OriginalPaper | Chapter

13. Photodynamic Therapy

Authors : Keiichi Imato, Yousuke Ooyama

Published in: Progress in the Science of Functional Dyes

Publisher: Springer Singapore

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Abstract

Photosensitizing dyes with the ability to produce singlet oxygen (¹O₂) under light irradiation can be used for photodynamic therapy (PDT), a treatment of early-stage cancer with less stress on bodies, where the photogenerated ¹O₂ destroys cancer cells. For PDT use, photosensitizing dyes require several capabilities such as strong photoabsorption in the phototherapeutic window (650–900 nm), high ¹O₂ generation quantum yield (Φ_Δ), good water solubility, and low toxicity without light irradiation. Therefore, the effects of chemical structures and substituents of photosensitizing dyes on these properties have been investigated, which enables to create new photosensitizing dyes with excellent performance for PDT. This chapter overviews recent studies and developments in photosensitizing dyes with a focus on porphyrin, phthalocyanine, boron-dipyrromethene (BODIPY), xanthene, phenothiazinium, heteropolycycle, pyrylium, azinium, squalin, and transition metal (Ru, Ir, Pt) complex skeletons.

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Title: Photodynamic Therapy
Authors: Keiichi Imato
Yousuke Ooyama
Publisher: Springer Singapore
Book: Progress in the Science of Functional Dyes
Print ISBN: 978-981-334-391-7

Electronic ISBN: 978-981-334-392-4

Copyright Year: 2021
DOI: https://doi.org/10.1007/978-981-33-4392-4_13