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Published in:
2018 | OriginalPaper | Chapter
Physics-Based Simulation to Enable Ultrasound Monitoring of HIFU Ablation: An MRI Validation
Authors : Chloé Audigier, Younsu Kim, Nicholas Ellens, Emad M. Boctor
Published in: Medical Image Computing and Computer Assisted Intervention – MICCAI 2018
Publisher: Springer International Publishing
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Abstract
High intensity focused ultrasound (HIFU) is used to ablate pathological tissue non-invasively, but reliable and real-time thermal monitoring is crucial to ensure a safe and effective procedure. It can be provided by MRI, which is an expensive and cumbersome modality.
We propose a monitoring method that enables real-time assessment of temperature distribution by combining intra-operative ultrasound (US) with physics-based simulation. During the ablation, changes in acoustic properties due to rising temperature are monitored using an external US sensor. A physics-based HIFU simulation model is then used to generate 3D temperature maps at high temporal and spatial resolutions. Our method leverages current HIFU systems with external low-cost and MR-compatible US sensors, thus allowing its validation against MR thermometry, the gold-standard clinical temperature monitoring method.
We demonstrated in silico the method feasibility, performed sensitivity analysis and showed experimentally its applicability on phantom data using a clinical HIFU system. Promising results were obtained: a mean temperature error smaller than \(1.5\,^\circ {\text {C}}\) was found in four experiments.