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Artificial Intelligence (AI) for Dental Intraoral Film Mounting Read chapter Read first chapter

2020 | OriginalPaper | Chapter

Point-of-Care Testing System of Uric Acid for the Prevention from Urolithiasis Recurrence

Authors : Lin-Chen Yen, Cheanyeh Cheng, Wen-Yaw Chung, Vincent Tsai

Published in: Future Trends in Biomedical and Health Informatics and Cybersecurity in Medical Devices

Publisher: Springer International Publishing

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Abstract

In this study, a simple, novel and inexpensive third generation electrochemical uric acid (UA) biosensor based on three-electrode point-of-care test strip was proposed. On the low-cost screen-printed three silver-based electrodes test strip, the Ag/AgCl reference electrode was first formed by simple electrodeposition with one silver electrode, then the working electrode was prepared by the successive coating of redox mediator, polymer hydrogel, and uricase onto the surface of another silver electrode, the third bare silver electrode was served as the counter electrode to complete the uric acid test strip, which has the advantages of lower oxidation potential, faster response time, higher sensitivity, and wider detecting range.
The three-electrode uric acid test strip specifically and directly senses uric acid in the test sample, and the signal is promptly transferred to the amperometric readout circuit that a stable bias voltage is applied by a bandgap circuit. After initial processing, the analog signal is converted to a digital signal which is calculated with the algorithm of microcontroller to produce a value of user-readable mode. Finally, the digital result is displayed on the liquid-crystal-display (LCD) panel. The complete set of uric acid point-of-care testing system will be used to assess the uric acid condition in the urine of a urolithiasis patient and will be helpful in the diagnosis of urolithiasis.
This uric acid biosensor can be used for testing uric acid either in urine or blood specimen. As combined with other biosensors such as calcium ions, pH, and conductivity, etc., it can be extended to develop a multi-parameter detection system and apply for the prevention of urolithiasis recurrence.

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Metadata
Title
Point-of-Care Testing System of Uric Acid for the Prevention from Urolithiasis Recurrence
Authors
Lin-Chen Yen
Cheanyeh Cheng
Wen-Yaw Chung
Vincent Tsai
Copyright Year
2020
Book
Future Trends in Biomedical and Health Informatics and Cybersecurity in Medical Devices

Print ISBN: 978-3-030-30635-9

Electronic ISBN: 978-3-030-30636-6

Copyright Year: 2020

DOI
https://doi.org/10.1007/978-3-030-30636-6_9