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Polymer Hydrogel-Clay (Nano)Composites Read chapter Read first chapter

2018 | OriginalPaper | Chapter

6. Polysaccharide Containing Gels for Pharmaceutical Applications

Authors : Catalina Natalia Cheaburu-Yilmaz, Sakine Tuncay Tanriverdi, Ozgen Ozer, Cornelia Vasile

Published in: Polymer Gels

Publisher: Springer Singapore

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Abstract

Bio-derived polymers are falling into the needs of pharmaceutical formulations for topical applications due to their gelling ability. Generally, in topical delivery, as an alternative way for local and systemic application of active substances, formulations in gelling form are preferred as they have multiple advantages, e.g., minimize systemic side effects, avoid gastrointestinal irritation, prevent the metabolism of the active substance in liver, etc. The present chapter reviews bio-based polymers with special reference to polysaccharides-based hydrogels with respect to their pharmaceutical applications.

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Literature
Agban Y, Lian J, Prabakar S, Seyfoddin A, Rupenthal ID (2016) Nanoparticle cross-linked collagen shields for sustained delivery of pilocarpine hydrochloride. Intern J Pharm 501:96–101CrossRef
Ahmad M, Asifmahmood SMR (2016) Hydrogel microparticles as an emerging tool in pharmaceutical field: a review. Adv Polym Technol 21:535
Ahmed EM (2015) Hydrogel: preparation, characterization, and applications: a review. J Adv Res 6:105–121PubMedCrossRef
Aktar B, Erdal MS, Sagirli O, Gungor Ozsoy Y (2014) Optimization of biopolymer based transdermal films of metoclopramide as an alternative delivery approach. Polymers 6:1350–1365CrossRef
Alur HH, Johnston TP, Mitra AK (2001) Encyclopedia of pharmaceutical technology. In: Superbrick J, Boylan JC (eds) Peptides and proteins: buccal absorption. Marcel Dekker Inc., New York pp, pp 193–218
Andrews GP, Laverty TP, Jones DS (2009) Mucoadhesive polymeric platforms for controlled drug delivery. Eur J Pharm Biopharm 71:505–518PubMedCrossRef
Aroguz AZ, Baysal K, Baysal BM (2010) Preparation and characterization of hydrogels of several polysaccarides for biomaterials applications hydrogels. Chap. 7 in biomaterials applications contemporary science of polymeric materials. ACS Symp Ser 1061:93–110CrossRef
Ay Senyigit Z, Karavana SY, Erac B, Gursel O, Hosgor Limoncu M, Baloglu E (2014) Evaluation of chitosan based vaginal bioadhesive gel formulations for antifungal drugs. Acta Pharm 64:139–156CrossRef
Babu RP, O’Connor K, Seeram R (2013) Current progress on bio-based polymers and their future trends. Progr in Biomater 2:8–16CrossRef
Bekturov EV, Bimendina LA (1981) Interpolymer complexes. Adv Polym Sci 41:99–147CrossRef
Bernkop-Schnurch A, Hornof M (2003) Intravaginal drug delivery: design, challenges and solutions. Am J Drug Deliv 1:241–254CrossRef
Bokias G, Mylonas Y, Staikos G, Bumbu GG, Vasile C (2001) Synthesis and aqueous solution properties of novel thermoresponsive graft copolymers based on a carboxymethylcellulose backbone. Macromolecules 34:4958–4964CrossRef
Borzacchiello A, Russo L, Malle BM, Schwach-Abdellaoui K, Ambrosio L (2015) Hyaluronic acid based hydrogels for regenerative medicine applications. BioMed Res Int 2015 871218:12
Braccini I, Perez S (2001) Molecular basis of Ca2+-induced gelation in alginates and Pectins: the egg-box model revisited. Biomacromol 2:1089–1096CrossRef
Butnaru E, Cheaburu CN, Yilmaz O, Pricope GM, Vasile C (2015) Poly(vinyl alcohol)/chitosan/ montmorillonite nanocomposites for food packaging applications: influence of montmorillonite content. High Perform Polym (0954008315617231)
Buwalda SJ, Boere KWM, Dijkstra PJ, Feijen J, Vermonden T, Hennink WE (2014) Hydrogels in a historical perspective: from simple networks to smart materials. J Controlled Release 190:254–273CrossRef
Calles JA, Lopez-García A, Valles EM, Palma SD, Diebol Y (2016a) Preliminary characterization of dexamethasone-loaded cross-linked hyaluronic acid films for topical ocular therapy. Intern J Pharm 509:237–243CrossRef
Calles JA, Ressia JA, Llabot JM, Valles EM, Palma SD (2016b) Hyaluronan-itaconic acid–glutaraldehyde films for biomedical applications: preliminary studies. Sci Pharm 84:61–72PubMedCrossRef
Carmona-Moran CA, Zavgorodny O, Penman AD, Kharlampiev E, Bridges SL Jr, Hergenrother RW, Singh JA, Wick TM (2016) Development of gellan gum containing formulations for transdermal drug delivery: component evaluation and controlled drug release using temperature responsive nanogels. Intern J Pharm 509:465–476CrossRef
Cerchiara T, Abruzzo A, Parolina C, Vitali B, Bigucci F, Gallucci MC, Nicolettac FP, Luppi B (2016) Microparticles based on chitosan/carboxymethylcellulose polyelectrolyte complexes for colon delivery of vancomycin. Carbohydr Polym 143:124–130PubMedCrossRef
Corobea MC, Muhulet O, Miculescu F, Antoniac IV, Vuluga Z, Florea D et al (2016) Novel nanocomposite membranes from cellulose acetate and clay-silica nanowires. Polym Adv Technol 27(12):1586–1595CrossRef
Chaterji S, Kwon IK, Park K (2007) Smart polymeric gels: redefining the limits of biomedical devices. Progr Polym Sci. 32:1083–1122CrossRef
Cheaburu CN, Bumbu GG (2009) Degradable interpolymeric complexes, Chap. 10. In: Vasile C, Zaikov G, Brill (eds) Environmentally degradable materials based on multicomponent polymeric systems, 654 pages
Cheaburu CN, Vasile C (2008) Responsive freeze-drying interpolymeric associations of alginic acid and poly (N-Isopropyl Acrylamide). II. Transition and temperature dependence on pH and composition. Cell Chem Technol 42:207–212
Cheaburu-Yilmaz CN, Yilmaz O, Vasile C (2015a) Eco-friendly chitosan-based nanocomposites: chap. In eco-friendly Polymer Nanocomposites. In: Thakur VK, Thakur, MK (eds) Chem Appl Adv Struct Mater 74:341–386
Cheaburu-Yilmaz CN, Dumitriu RP, Nistor MT, Lupusoru C, Popa MI, Profire L, Silvestre C, Vasile C (2015b) Biocompatible and biodegradable chitosan/clay nanocomposites as new carriers for theophylline controlled release. Br J Pharm Res 6:228–254CrossRef
Cheaburu-Yilmaz CN, Bibire N, Yilmaz O, Pamfil D, Lupusoru C, Lupuşoru RV, Vasile C (2017) Freeze-thaw PVA/hyaluronic acid hydrogels for controlled delivery of methotrexate for psoriasis therapy (in press)
Chen Q, Chen H, Zhu L, Zheng J (2015) Fundamentals of double network hydrogels. J Mater Chem B 3:3654–3676CrossRefPubMed
Chenite A, Chaput C, Wang D, Combes C, Buschmann MD, Hoemann CD, Leroux JC, Atkinson BL, Binette F, Selmani A (2000) Novel injectable neutral solutions of Chitosan form biodegradable gels in situ. Biomaterials 21:2155–2161PubMedCrossRef
Cojocariu A, Porfire L, Cheaburu C, Vasile C (2012) Chitosan/montmorillonite composites as matrices for prolonged delivery of some novel nitric oxide donor compounds based on theophylline and paracetamol. Cell Chem Technol 46:35–43
Das Neves J, Bahia MF (2006) Gels as vaginal drug delivery systems. Intern J Pharm 318:1–14CrossRef
Davis SS (1971) Viscoelastic properties of pharmaceutical semisolids IV: destructive oscillatory testing. J Pharm Sci 60:1356–1360PubMedCrossRef
De la Mata A, Nieto-Miguel T, Lopez-Paniagua M, Galindo S, Aguilar MR, García-Fernandez L, Gonzalo S, Vazquez B, Roman JS, Corrales RM (2013) Chitosan-gelatin biopolymers as carrier substrata for limbal epithelial stem cells. J Mater Sci Mater Med 24:2819–2829PubMedCrossRef
De Pinho Neves AL, Cardoso Milioli C, Muller L, Gracher Riella H, Kuhnena NC, Stulzer HK (2014) Factorial design as tool in chitosan nanoparticles development by ionic gelation technique. Colloids and surfaces a: physicochem. Eng Aspects 445:34–39CrossRef
Dumitriu RP, Mitchell GR, Vasile C (2011) Rheological and thermal behaviour of poly (N-isopropylacrylamide)/alginate smart polymeric networks. Polym Intern 60:1398–1407CrossRef
Dumitriu RP, Oprea AM, Cheaburu CN, Nistor MT, Novac O, Ghiciuc CM, Profire L, Vasile C (2014) Biocompatible and biodegradable alginate/poly (N-isopropylacrylamide) hydrogels for sustained theophylline release. J Appl Polym Sci 131:40733CrossRef
Dumitriu RP, Profire L, Nita LE, Dragostin OM, Ghetu N, Peptu D, Vasile C (2015) Sulfadiazine-chitosan conjugates and their polyelectrolyte complexes with hyaluronate destined in the management of burn wounds. Materials 8:317–338PubMedPubMedCentralCrossRef
Dumitriu S (2004) Polysaccharides: structural diversity and functional versatility, 2nd Edn. CRC Press, Science, p 1224
Dutta S, Samanta P, Dhara D (2016) Temperature, pH and redox responsive cellulose based hydrogels for protein delivery. Intern J Biol Macromol 87:92–100CrossRef
Ebara M, Kotsuchibashi Y, Narain R, Idota N, Kim YJ, Hoffman JM, U to K, Aoyagi T (2014) Smart hydrogels Chap. 2 in smart biomaterials. Springerm, p 118
Eldin MSM, Kamoun EA, Sofan MA, Elbayomi SM (2015) L-Arginine grafted alginate hydrogel beads: a novel pH-sensitive system for specific protein delivery. Arab J Chem 8:355–365CrossRef
Fan L, Yang H, Yang J, Peng M, Hu J (2016) Preparation and characterization of chitosan/gelatin/PVA hydrogel for wound dressings. Carbohyd Polym 146:427–434CrossRef
Fathalla ZMA, Khaled KA, Hussein AK Alany RG, Vangala A (2016) Formulation and corneal permeation of ketorolac tromethamine-loaded chitosan nanoparticles. Drug Dev Ind Pharm 42:514–524
Ferry JD (1961) Viscoelastic properties of polymers. Wiley, New York, p 391
Fini A, Bergamante V, Ceschel GC (2011) Mucoadhesive gels designed for the controlled release of chlorhexidine in the oral cavity. Pharmaceutics 3:665–679PubMedPubMedCentralCrossRef
Freundlich H, Rawitzer W (1927) Influence of metals on thixotropic sols and gels. Kolloid-Z 41:102–104CrossRef
Fu S, Thacker A, Sperger DM, Boni RL, Buckner IS, Velankar S, Munson EJ, Block LH (2011) Relevance of rheological properties of sodium alginate in solution to calcium alginate gel properties. AAPS Pharmscitech 12:453–460PubMedPubMedCentralCrossRef
Gaharwar AK, Peppas NA, Khademhosseini A (2014) Nanocomposite hydrogels for biomedical applications. Biotechnol Bioeng 111:441–453PubMedCrossRef
Gamboa A, Araujo V, Caro N, Gotteland M, Abugoch L, Tapia C (2015) Spray freeze-drying as an alternative to the ionic gelation method to produce chitosan and alginate nano-particles targeted to the colon. J Pharm Sci 104:4373–4385PubMedCrossRef
Gandhi RB, Robinson JR (1994) Oral cavity as a site for bioadhesive drug delivery. Adv Drug Deliv Rev 13:43–74CrossRef
Grant GT, Morris ER, Rees DA, Smith PJC, Thom D (1973) Biological interactions between polysaccharides and divalent cations: the egg-box model. FEBS Lett 32:195–198CrossRef
Guilherme MR, Aouada FA, Fajardo AR, Martins AF, Paulino AT, Davi MT, Rubira AF, Muniz EC (2015) Superabsorbent hydrogels based on polysaccharides for application in agriculture as soil conditioner and nutrient carrier: a review. Eur Polym J 72:365–385CrossRef
Gulrez KHS, Phillips GO, Al-Assaf S (2011) Hydrogels: methods of preparation, characterisation and applications. In: Progress in molecular and environmental bioengineering-from analysis and modeling to technology applications. InTech Ed Carpi A (ISBN: 978-953-307-268-5)
Guo W, Orbach R, Mironi-Harpaz I, Seliktar D, Willner I (2013) Fluorescent DNA hydrogels composed of nucleic acid-stabilized silver nanoclusters. Small 9:3748–3752PubMedCrossRef
Gupta H, Sharma A (2009) Ion activated bioadhesive in situ gel of clindamycin for vaginal application. Int J Drug Deliv 10:32–40CrossRef
Gupta P, Vermani K, Garg S (2002) Hydrogels: from controlled release to pH-responsive drug delivery. Drug Discov Today 7:569–579PubMedCrossRef
He CL, Kim SW, Lee DS (2008) In situ gelling stimuli-sensitive block copolymer hydrogels for drug delivery. J Control Release 127:189–207PubMedCrossRef
Hennink WE, Nostrum CFV (2002) Novel crosslinking methods to design hydrogels. Adv Drug Delivery Rev 54:13–36CrossRef
Higham AK, Bonino CA, Raghavan SR, Khan SA (2014) Photo-activated ionic gelation of alginate hydrogel: real-time rheological monitoring of the two-step crosslinking mechanism. Soft Matter 10:4990–5002PubMedCrossRef
Hoare TR, Kohane DS (2008) Hydrogels in drug delivery: progress and challenges. Polymer 49:1993–2007CrossRef
Hu X, Gong X (2016) A new route to fabricate biocompatible hydrogels with controlled drug delivery behavior. J Colloid Interf Sci 470:62–70CrossRef
Huang CL, Chen YB, Lo YL, Lin YH (2016) Development of chitosan/βglycerophosphate/glycerol hydrogel as a thermosensitive coupling agent. Carbohyd Polym 147:409–414CrossRef
Huang Y, Szleifer I, Peppas NA (2002) A molecular theory of polymer gels. Macromolecules 35:1373–1380CrossRef
Hurler J, Engesland A, Kermany BP, Skalko-Basnet N (2012) Improved texture analysis for hydrogel characterization: gel cohesiveness, adhesiveness, and hardness. J Appl Polym Sci 125:180–188CrossRef
Hussain A, Ahsan F (2005) The vagina as a route for systemic drug delivery. J Control Release 103:301–313PubMedCrossRef
Ibrahim MM, Hafez SA, Mahdy MM (2013) Organogels, hydrogels and bigels as transdermal delivery systems for diltiazem hydrochloride. Asian J Pharm Sci 8:48–57CrossRef
Illum L (2012) Nasal drug delivery—recent developments and future prospects. J Control Release 161:254–263PubMedCrossRef
Indulekha S, Arunkumar P, Bahadur D, Srivastava R (2016) Thermoresponsive polymeric gel as an on-demand transdermal drug delivery system for pain management. Mat Sci Eng C 62:113–122CrossRef
Ishida M, Nambu N, Nagai T (1983) Highly viscous gel ointment containing Carbopol for application to the oral mucosa. Chem Pharm Bull 31:4561–4564CrossRef
Jabeen S, Maswal M, Chat OA, Rather GM, Dar AA (2016) Rheological behavior and Ibuprofen delivery applications of pH responsive composite alginate hydrogels. Colloids Surf B: Biointerfaces 139:211–218PubMedCrossRef
Javvaji V, Baradwaj AG, Payne GF, Raghavan SR (2011) Light-activated ionic gelation of common biopolymers. Langmuir 27:12591–12596PubMedCrossRef
Jeong B, Kim SW, Bae YH (2012) Thermosensitive sol–gel reversible hydrogels. Adv Drug Delivery Rev 64:154–162CrossRef
Johnson JA Turro N, Koberstein JT, Mark JE (2010) Some hydrogels having novel molecular structures. Prog Polym Sci 35:332–337
Jones DS, Woolfson AD, Brown AF (1997) Textural, viscoelastic and mucoadhesive properties of pharmaceutical gels composed of cellulose polymers. Intern J Pharm 151:223–233CrossRef
Kakuta T, Takashima Y, Harada A (2013) Highly elastic supramolecular hydrogels using host-guest inclusion complexes with cyclodextrins. Macromolecules 46:4575–4579CrossRef
Kalam MA (2016) Development of chitosan nanoparticles coated with hyaluronic acidfor topical ocular delivery of dexamethasone. Intern J Biol Macromol 89:127–136CrossRef
Karavasili C, Fatouros DG (2016) Smart materials: in situ gel-forming systems for nasal delivery. Drug Discovery Today 21:157–166PubMedCrossRef
Khairnar GA, Sayyad FJ (2010) Development of buccal drug delivery system based on mucoadhesive polymers. Int J PharmTech Res 2:719–735
Klouda L (2015) Thermoresponsive hydrogels in biomedical applications a seven-year update. Eur J Pharm Biopharm 97:338–349PubMedCrossRef
Klouda L, Mikos AG (2008) Thermoresponsive hydrogels in biomedical applications—a review. Eur J Pharm Biopharm 68:34–45
Kong BJ, Kim A, Park SN (2016) Properties and in vitro drug release of hyaluronic acid-hydroxyethylcellulose hydrogels for transdermal delivery of isoliquiritigenin. Carbohydr Polym 147:473–481PubMedCrossRef
Kono H, Teshirogi T (2015) Cyclodextrin-grafted chitosan hydrogels for controlled drug delivery. Internl J Biol Macromol 72:299–308CrossRef
Kontogiorgos V, Smith AM, Morris GA (2015) The parallel lives of polysaccharides in food and pharmaceutical formulations. Curr Opin Food Sci 4:13–18CrossRef
Korsmeyer RW, Lustig SR, Peppas NA (1968) Solute and penetrant diffusion in swellable polymers. I. Mathematical modeling. J Polym Sci Part B: Polym Phys 24:395–408CrossRef
Lai JY (2013) Influence of solvent composition on the performance of carbodiimide cross-linked gelatin carriers for retinal sheet delivery. J Mater Sci Mater Med 24:2201–2210PubMedCrossRef
Lai JY, Ma DHK, Lai MH, Li YT, Chang RJ, Chen LM (2013) Characterization of cross-linked porous gelatin carriers and their interaction with corneal endothelium: biopolymer concentration effect. PLoS ONE 8:540–558CrossRef
Langasco R, Spada G, Tuncay Tanriverdi S, Rassu G, Giunchedi P, Ozer O, Gavini E (2016) Bio-based topical system for enhanced salicylic acid delivery: preparation and performance of gels. J Pharm Pharmacol 68:999–1009PubMedCrossRef
Larraneta E, Lutton REM, Woolfson AD, Donnelly RF (2016) Microneedle arrays as transdermal and intradermal drug delivery systems: materials science, manufacture and commercial development. Mater Sci Eng R 104:1–32CrossRef
Leea CH, Moturia V, Lee Y (2009) Thixotropic property in pharmaceutical formulation. J Control Release 136:88–98CrossRef
Leong JY, Lam WH, Ho KW, Voo WP, Lee MFX, Lim HP, Lim SL, Tey BT, Poncelet D, Chan ES (2016) Advances in fabricating spherical alginate hydrogels with controlled particle designs by ionotropic gelation as encapsulation systems. Particuology 24:44–60CrossRef
Li J, Liu D, Tana G, Zhao Z, Yang X, Pan W (2016) A comparative study on the efficiency of chitosan-N-acetylcysteine, chitosan oligosaccharides or carboxymethyl chitosan surface modified nanostructured lipid carrier for ophthalmic delivery of curcumin. Carbohydr Polym 146:435–444PubMedCrossRef
Lim MPA, Lee WL, Widjaja E, Loo SCJ (2013) One-step fabrication of core–shell structured alginate–PLGA/PLLA microparticles as a novel drug delivery system for water soluble drugs. Biomater Sci 1:486–493CrossRefPubMed
Lim YM, Gwon HJ, Park JS, Nho YC Shim JW, Kwon IK, Kim SE, Baik SH (2011) Synthesis and properties of hyaluronic acid containing copolymers crosslinked by γ-ray irradiation. Macromol Res 19:436–441
Liow SS, Dou Q, Kai D, Karim AA, Zhang K, Xu F, Loh XJ (2016) Thermogels. In Situ gelling biomaterial. ACS Biomater Sci Eng 2:295–316CrossRefPubMed
Liu H, Sui X, Xu H, Zhang L, Zhong Y, Mao Z (2016) Self-healing polysaccharide hydrogel based on dynamic covalent enamine bonds. Macromol Mater Eng 301:725–732CrossRef
Liu KL, Zhang Z, Li J (2011) Supramolecular hydrogels based on cyclodextrin–polymer polypseudorotaxanes: materials design and hydrogel properties. Soft Matter 7:11290–11297CrossRef
Liu ZQ, Wei Z, Zhu XL, Huang GY, Xu F, Yang JH, Osada Y, Zrínyig M, Yong JHL, Chena M (2015) Dextran-based hydrogel formed by thiol-michael addition reaction for 3D cell encapsulation. Colloids Surf, B 128:140–148CrossRef
Liuzzi R, Carciati A, Guido S, Caserta S (2016) Transport efficiency in transdermal drug delivery: What is the role of fluid microstructure? Colloids Surf, B 139:294–305CrossRef
Lucero MJ, Ferris C, Sánchez-Gutiérrez CA, Jiménez-Castellanosa MR, de-Paz MV (2016) Novel aqueous chitosan-based dispersions as efficient drug delivery systems for topical use. Rheological, textural and release studies. Carbohydr Polym 151:692–699
Mabrouk M, Chejara DR, Mulla JAS, Badhe RV, Choonara YE, Kumar P, du Toit LC, Pillay V (2015) Design of a novel crosslinked HEC-PAA porous hydrogel composite for dissolution rate and solubility enhancement of efavirenz. Intern J Pharm 490:429–437CrossRef
Machín R, Isasi JR, Velaz I (2012) β-cyclodextrin hydrogels as potential drug delivery systems. Carbohyd Polym 87:2024–2030CrossRef
Mahdavinia GR, Mousanezhad S, Hosseinzadeh H, Darvishi F, Sabzi M (2016) Magnetic hydrogel beads based on PVA/sodium alginate/laponite RD and studying their BSA adsorption. Carbohydr Polym 147:379–391PubMedCrossRef
Malda J, Visser J, Melchels FP, Jüngst T, Hennink WE, Dhert WJA, Groll J, Hutmacher DW (2013) 25th anniversary article: engineering hydrogels for biofabrication. Adv Mater 25:5011–5028PubMedCrossRef
Mastropietro DJ, Nimroozi R, Omidian H (2013) Rheology in pharmaceutical formulations-a perspective. J Dev Drugs 2:108–116
Mayol L, De Stefano D, De Falco F, Carnuccio R, Maiuri MC, De Rosa G (2014) Effect of hyaluronic acid on the thermogelation and biocompatibility of its blends with methyl cellulose. Carbohyd Polym 112:480–485CrossRef
Mercado SA, Slater NKH (2016) The functional and structural effects of an amphipathic pH responsive biopolymer: a comprehensive study in osteosarcoma cells. Eur Polymer J 74:158–167CrossRef
Mezger TG (2006) The rheology handbook: for users of rotational and oscillatory rheometers, 2nd revised edn. Vincentz Network, Hannover
Mikos AG, Peppas NA (1986) Comparison of experimental technique for measurement of the bioadhesive forces of polymeric materials with soft tissues. Proc Int Symp Control Release Bioact Mater 13:97–100
Miculescu M, Thakur VK, Miculescu F, Voicu SI (2016) Graphene-based polymer nanocomposite membranes: a review. Polym Adv Technol 27(7):844–859CrossRef
Miyata T, Rubin AL, Stenzel KH, Dunn MW (1979) US Patent 4, 164, 559
Molina R, Jovancic P, Vilchez S, Tzanov T, Solans C (2014) In situ chitosan gelation initiated by atmospheric plasma treatment. Carbohydr Polym 103:472–479PubMedCrossRef
Morris ER, Rees DA, Thom D, Boyd J (1978) Chiroptical and stoichiometric evidence of a specific, primary dimerisation process in alginate gelation. Carbohydr Res 66:145–154CrossRef
Murthy S, Shivakumar H (2010) Topical and transdermal drug delivery. Handbook of Non-Invasive Drug Delivery Systems, pp 1–36
Na YH (2013) Double network hydrogels with extremely high toughness and their applications. Korea-Aust Rheol J 25:185–196CrossRef
Nie J, Lu W, Ma J, Yang L, Wang Z, Qin A, Hu Q (2015) Orientation in multi-layer chitosan hydrogel: morphology. Mech Des Principle Sci Rep 5:7635CrossRef
Nishida Y, Ohtsuki S, Araie Y, Umeki Y, Endo M, Emura T, Hidaka K, Sugiyama H, Takahashi Y, Takakura Y, Nishikawa M (2016) Self-assembling DNA hydrogel-based delivery of immunoinhibitory nucleic acids to immune cells. Nanomedicine: nanotechnology. Biol Med 12:123–130
Pãduraru OM, Vasile C, Pațachia S, Grigoras C, Oprea AM (2010) Membranes based on poly(vinyl alcohol)/beta-cyclodextrin blends. Polimery 55:473–478
Pamfil D, Vasile C (2017) Nanogels of natural polymers Chap. 4 in handbook on “Polymer Gels”. Section “polymer gels: science and fundamentals” (in press)
Papkov SP (1974) Gel-like state of polymers. Khimiya, Moscow
Park H, Robinson JR (1985) Physicochemical properties of water insoluble polymers important to mucin/epithelial adhesion. J Control Rel 2:257–275CrossRef
Park K, Robinson JR (1984) Bioadhesive polymers as platforms for oral-controlled drug delivery: method to study bioadhesion. Int J Pharm 198:107–127CrossRef
Patel P, Patel P (2015) Formulation and evaluation of clindamycin HCl in situ gel for vaginal application. Intern J Pharm Investig 5:50–56CrossRef
Pappu A, Patil V, Jain S, Mahindrakar A, Haque R, Thakur VK (2015) Advances in industrial prospective of cellulosic macromolecules enriched banana biofibre resources: a review. Int J Biol Macromol 79:449–458PubMedCrossRef
Pappu A, Saxena M, Thakur VK, Sharma A, Haque R (2016) Facile extraction, processing and characterization of biorenewable sisal fibers for multifunctional applications. J Macromol Sci Part A 53(7):424–432CrossRef
Patel PV, Koyani V (2014) Smart polymers: innovative drug delivery system. World J Pharm Pharm Sci 3:508–527
Paudel KS, Milewski M, Swadley CL, Brogden NK, Ghosh P, Stinchcomb AL (2010) Ther Deliv 1:109–131PubMedCrossRef
Peak CW, Wilker JJ, Schmidt G (2013) A review on tough and sticky hydrogels. Colloid Polym Sci 291:2031–2047CrossRef
Peppas NA, Buri PA (1985) Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissues. J Control Release 2:257–275CrossRef
Perioli L, Ambrogi V, Venezia L, Pagano C, Ricci M, Rossi C (2008) Chitosan and a modified chitosan as agents to improve performances of mucoadhesive vaginal gels. Colloids Surf, B 66:141–145CrossRef
Plazinski W (2011) Molecular basis of calcium binding by polyguluronate chains. Revising the egg-box model. J Comput Chem 32:2988–2995PubMedCrossRef
Prabaharan M, Mano JF (2006) Stimuli-responsive hydrogels based on polysaccharides incorporated with thermo-responsive polymers as novel biomaterials. Macromol Biosci 8:991–1008CrossRef
Prasertsung I, Damrongsakkul S, Terashima C, Saito N, Takai O (2012) Preparation of low molecular weight chitosan using solution plasma system. Carbohydr Polym 87:2745–2749CrossRef
Rasente RY, Imperiale JC, Lázaro-Martínez JM, Gualco L, Oberkersch R, Sosnik A, Calabrese GC (2016) Dermatan sulfate/chitosan polyelectrolyte complex with potential application in the treatment and diagnosis of vascular disease. Carbohydr Polym 144:362–370PubMedCrossRef
Rodkate N, Rutnakornpituk M (2016) Multi-responsive magnetic microsphere of poly (N-isopropylacrylamide)/carboxymethylchitosan hydrogel for drug controlled release. Carbohydr Polym 151:251–259PubMedCrossRef
Rogovina LZ, Vasilev VG, Braudo EE (2008) Definition of the Concept of Polymer Gel. Polymer Sci Ser C 50:85–92CrossRef
Rose JB, Pacelli S, El Haj AJ, Dua HS, Hopkinson A, White LJ, Rose FRAJ (2014) Gelatin-based materials in ocular tissue engineering. Materials 7:3106–3135PubMedPubMedCentralCrossRef
Rosiak JM, Yoshii F (1999) Hydrogels and their medical applications. Nucl Instr Meth Phys Res B 151:56–64CrossRef
Rubinstein M, Colby RH (2003) Polymer physics. Oxford University Press, Oxford
Russo E, Selmin F, Baldassari S, Gennari CGM, Caviglioli G, Cilurzo F, Minghetti P, Parodi B (2016) A focus on mucoadhesive polymers and their application in buccal dosage forms. J Drug Delivery Sci Techn 32:113–125CrossRef
Russo PS (1987) A perspective on reversible gels and related systems. In: Russo PS (eds) Chapter 1 in reversible polymeric gels and related systems 350:1–21
Ryu JH, Lee Y, Kong WH, Kim TG, Park TG, Lee H (2011) Catechol-functionalized chitosan/pluronic hydrogels for tissue adhesives and hemostatic materials. Biomacromol 12:2653–2659CrossRef
Saettone MF, Cheton P, Torracca MT, Burgalassi S, Giannaccini B (1989) Evaluation of muco-adhesive properties and in vivo activity of ophthalmic vehicles based on hyaluronic acid. Int J Pharm 51:203–212CrossRef
Sagiri SS, Behera B, Rafanan RR, Bhattacharya C, Pal K, Banerjee I, Rousseau D (2014) Organogels as matrices for controlled drug delivery: a review on the current state. Soft Mater 12:47–72CrossRef
Salamat-Miller N, Chittchang M, Johnston TP (2005) The use of mucoadhesive polymers in buccal drug delivery. Adv Drug Delivery Rev 57:1666–1691CrossRef
Salmaso S, Semenzato A, Bersani S, Matricardi P, Rossi F, Caliceti P (2007) Cyclodextrin/PEG based hydrogels for multi-drug delivery. Int J Pharm 345:42–50PubMedCrossRef
Sanchez MP, Martín-Illana A, Ruiz-Caro R, Bermejo P, Abad MJ, Carro R, Bedoya LM, Tamayo A, Rubio J, Fernández-Ferreiro A, Otero-Espinar F, Veiga MD (2015) Chitosan and kappa-carrageenan vaginal acyclovir formulations for prevention of genital herpes. In vitro and ex vivo evaluation. Mar Drugs 13:5976–5992CrossRef
Sander C, Madsen DK, Hyrup B, Nielsen HM, Rantanen J, Jacobsen J (2013) Characterization of spray dried bioadhesive metformin microparticles for oromucosal administration. Eur J Pharm Biopharm 85:682–688PubMedCrossRef
Secchi E, Roversi T, Buzzaccaro S, Piazza L, Piazza R (2013) Biopolymer gels with “physical” cross-links: gelation kinetics, aging, heterogeneous dynamics, and macroscopic mechanical properties. Soft Matter 9:3931–3944CrossRef
Senel S, Ikinci G, Kas S, Yousefi-Rad A, Sargon MF, Hinca AA (2000) Chitosan films and hydrogels of chlorhexidine gluconate for oral mucosal delivery. Int J Pharm 193:197–203PubMedCrossRef
Shi L, Yang L, Chen J, Pei Y, Chen M, Hui B, Li J (2004) Preparation and character-ization of pH-sensitive hydrogel of chitosan/poly (acrylic acid) co-polymer. J Biomater Sci Polym Ed 15:465–474PubMedCrossRef
Silva NHCS, Rodrigues AF, Almeida IF, Costa PC, Rosado C, Neta CP, Silvestre AJD, Freire CSR (2014) Bacterial cellulose membranes as transdermal delivery systems for diclofenac: in vitro dissolution and permeation studies. Carbohydr Polym 106:264–269PubMedCrossRef
Prabha SB (2013) Preparation and evaluation of pluronic lecithin organogel containing ricinoleic acid for transdermal drug delivery. Theses and dissertations. Paper 32
Singh NK, Lee DS (2014) In situ gelling pH- and temperature-sensitive biodegradable block copolymer hydrogels for drug delivery. J Control Release 193:214–227PubMedCrossRef
Singh R, Singh D (2012) Radiation synthesis of PVP/alginate hydrogel containing nanosilver as wound dressing. J Mater Sci: Mater Med 23:2649–2658
Singhal R, Gupta K (2016) A review: tailor-made hydrogel structures (classifications and synthesis parameters). Polymer-Plastics Technol Eng 55:54–70CrossRef
Sionkowska A, Kaczmarek B, Lewandowska K, Grabska S, Pokrywczynska M, Kloskowski T, Drewa T (2016) 3D composites based on the blends of chitosan and collagen with the addition of hyaluronic acid. Intern J Biol Macromols 89:442–448CrossRef
Smart JD (2005) The basics and underlying mechanisms of mucoadhesion. Adv Drug Delivery Rev 57:1556–1568CrossRef
Smart JD, Kellaway IW, Worthington HEC (1984) An in vitro investigation of mucosa adhesive materials for use in controlled drug delivery. J Pharm Pharmacol 36:295–299PubMedCrossRef
Solomonidou D, Cremer K, Krumme M, Kreuter J (2001) Effect of carbomer concentration and degree of neutralization on the mucoadhesive properties of polymer films. J Biomat Sci 12:1191–1205CrossRef
Strobel SA, Scher HB, Nitin N, Jeoh T (2016) In situ cross-linking of alginate during spray-drying to microencapsulate lipids in powder. Food Hydrocolloids 58:141–149CrossRef
Tanaka T (1985) in encyclopedia of polymer science and engineering. In: Klingsberg A, Piccinini P (eds), vol 7. Wiley, New York, p 514
Tanrıverdi ST, Ozer O (2013) Novel topical formulations of terbinafine-HCl for treatment of onychomycosis. Eur J Pharm Sci 48:628–636PubMedCrossRef
Thakur VK, Thakur MK (2014) Recent trends in hydrogels based on psyllium polysaccharide: a review. J Cleaner Prod 82:1–15CrossRef
Thakur VK, Thakur MK (2015) Recent advances in green hydrogels from lignin: a review. Int J Biol Macromol 72:834–847
Thakur MK, Thakur VK, Gupta RK, Pappu A (2016) Synthesis and applications of biodegradable soy based graft copolymers: a review. ACS Sustain Chem Eng 4:1–17CrossRef
Tomsic M, Prossnigg F, Glatter O (2008) A thermoreversible double gel: characterization of a methylcellulose and κ-carrageenan mixed system in water by SAXS, DSC and rheology. J Colloid Interface Sci 322:41–50PubMedCrossRef
Trovatti E, Freire CSR, Pinto PC, Almeida IF, Costa P, Silvestre AJD, Neto CP, Rosado C (2012) Bacterial cellulose membranes applied in topical and transdermal delivery of lidocaine hydrochloride and ibuprofen: in vitro diffusion studies. Intern J Pharm 435:83–87CrossRef
Trache D, Hazwan Hussin M, Mohamad Haafiz MK, Kumar Thakur V (2017) Recent progress in cellulose nanocrystals: sources and production. Nanoscale 9(5):1763–1786PubMedCrossRef
Ueda CT, Shah VP, Derdzinski K, Ewing G, Flynn G, Maibach H, Marques M, Rytting H, Shaw S, Thakker K, Yacobi (2009) A topical and transdermal drug products. Pharmacopeial Forum 35(3):750–764
Ullah F, Othman MBH, Javed F, Ahmad Z, Md Akil H (2015) Classification, processing and application of hydrogels: a review. Mater Sci Eng, C 57:414–433CrossRef
Vasanthra R, Sehgl PK, Rao KP (1988) Collagen ophthalmic inserts for pilocarpine drug delivery system. Int J Pharm 47:95–102CrossRef
Vasile C, Dumitriu RP, Cheaburu C, Oprea AM (2009) Architecture and composition influence on the properties of some smart polymeric materials designed as matrices in drug delivery systems. A Comp Study. Appl Sur Sci 256:65–71CrossRef
Venus M, Waterman J, McNab I (2011) Basic physiology of the skin. Surgery (Oxford) 29:471–474
Vinholis AHC, de Figueiredo LC, Marcantonio E Jr, Marcantonio RAC, Salvador SLS, Goissis G (2001) Subgingival utilization of a 1% chlorhexidine collagen gel for the treatment of periodontal pockets. A clinical and microbiological study. Braz Dent J 12:209–213PubMed
Vintiloiu A, Leroux JC (2008) Organogels and their use in drug delivery—a review. J Control Release 125:179–192PubMedCrossRef
Voicu, SI, Condruz RM, Mitran V, Cimpean A, Miculescu F, Andronescu C, Miculescu M, Thakur VK (2016) Sericin covalent immobilization onto cellulose acetate membrane for biomedical applications. ACS Sustain Chem Eng 4(3):1765–1774
Vulpe R, Popa M, Picton L, Balan V, Dulong V, Butnaru M, Verestiuc L (2016) Crosslinked hydrogels based on biological macromolecules with potential use in skin tissue engineering. Int J Biol Macromol 84:174–181PubMedCrossRef
Wang W, Zhang P, Shan W, Gao J, Liang W (2013) A novel chitosan-based thermosensitive hydrogel containing doxorubicin liposomes for topical cancer therapy. J Biomater Sci Polym Ed 24:1649–1659PubMedCrossRef
Wong CF, Yuen KH, Kok KP (1999) An in vitro method for buccal adhesion studies: importance of instrument variables. Int J Pharm 180:47–57PubMedCrossRef
Xu J, Li X, Sun F, Cao P (2010) PVA hydrogels containing beta-cyclodextrin for enhanced loading and sustained release of ocular therapeutics. J Biomater Sci Polym Ed 21:1023–1038PubMedCrossRef
Xu W, Qian J, Zhang Y, Suo A, Cui N, Wang J, Yao Y, Wang H (2016) A double-network poly (Ne-acryloyl L-lysine)/hyaluronic acid hydrogel as a mimic of the breast tumor microenvironment. Acta Biomater 33:131–141PubMedCrossRef
Yamamoto S, Hirata A, Ishikawa S, Ohta K, Nakamura K, Okinami S (2013) Feasibility of using gelatin-microbial transglutaminase complex to repair experimental retinal detachment in rabbit eyes. Graefe’s Arch Clin Exp Ophthalmol 251:1109–1114CrossRef
Zhou C, Wu Q (2011) A novel polyacrylamide nanocomposite hydrogel reinforced with natural chitosan nanofibers. Coll Surf B Biointer 84:155–162CrossRef
Zhou Y, Gao HL, Shen LL, Pan Z, Mao LB, Wu T, He JC, Zou DH, Zhang ZY, Yu SH (2016) Chitosan microspheres with an extracellular matrix-mimicking nanofibrous structure as cell carrier building blocks for bottom-up cartilage tissue engineering. Nanoscale 8:309–317PubMedCrossRef
Metadata
Title
Polysaccharide Containing Gels for Pharmaceutical Applications
Authors
Catalina Natalia Cheaburu-Yilmaz
Sakine Tuncay Tanriverdi
Ozgen Ozer
Cornelia Vasile
Copyright Year
2018
Publisher
Springer Singapore
Book
Polymer Gels

Print ISBN: 978-981-10-6085-4

Electronic ISBN: 978-981-10-6086-1

Copyright Year: 2018

DOI
https://doi.org/10.1007/978-981-10-6086-1_6

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