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Polymer Science, Series A

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01-11-2019 | MEDICAL POLYMERS

Polysaccharides Sterculia Gum/Psyllium Based Hydrogel Dressings for Drug Delivery Applications

Authors: Baljit Singh, Rajneesh, Baldev Singh, Ajay Kumar, Shikha Aery

Published in: Polymer Science, Series A | Issue 6/2019

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Abstract

Keeping in view the advantages of hydrogel based wound dressing, the present work explore the potential of sterculia gum and psyllium polysaccharides to prepare the moxifloxacin loaded hydrogel wound dressings for better wound care. The polymers were characterized by cryo scanning electron microscopy (cryoSEM), atomic force microscopy, ¹³C nuclear magnetic resonance spectroscopy and swelling studies. Evaluation of drug release mechanism and kinetic model from the polymer matrix was performed along with some biomedical properties of hydrogel dressing including wound fluid absorption, blood-compatibility, antioxidant activity, oxygen permeability, muco-adhesion, and mechanical properties. CryoSEM showed porous nature of the polymer film. One gram of the hydrogel dressing absorbed 14.7 g simulated wound fluid. Release of drugs (moxifloxacin) from drug loaded hydrogel dressings, occurred through non-Fickian diffusion mechanism in simulated wound fluid without any burst effect. Hydrogel dressing showed porous structures with good degree of mechanical strength, antioxidant activity and biocompatibility.

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Title: Polysaccharides Sterculia Gum/Psyllium Based Hydrogel Dressings for Drug Delivery Applications
Authors: Baljit Singh
Rajneesh
Baldev Singh
Ajay Kumar
Shikha Aery
Publication date: 01-11-2019
Publisher: Pleiades Publishing
Published in: Polymer Science, Series A / Issue 6/2019
Print ISSN: 0965-545X
Electronic ISSN: 1555-6107
DOI: https://doi.org/10.1134/S0965545X19060105

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