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01-02-2017 | Research Paper

Preparation and biodistribution of ⁵⁹Fe-radiolabelled iron oxide nanoparticles

Authors: Martina Pospisilova, Vojtech Zapotocky, Kristina Nesporova, Milan Laznicek, Alice Laznickova, Ondrej Zidek, Martin Cepa, Hana Vagnerova, Vladimir Velebny

Published in: Journal of Nanoparticle Research | Issue 2/2017

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Abstract

We report on the ⁵⁹Fe radiolabelling of iron oxide nanoparticle cores through post-synthetic isotope exchange (⁵⁹Fe-IONP_ex) and precursor labelling (⁵⁹Fe-IONP_pre). Scanning electron microscopy and dynamic light scattering measurements showed no impact of radiolabelling on nanoparticle size or morphology. While incorporation efficiencies of these methods are comparable—83 and 90% for precursor labelling and post-synthetic isotope exchange, respectively—⁵⁹Fe-IONP_pre exhibited much higher radiochemical stability in citrated human plasma. Quantitative ex vivo biodistribution study of ⁵⁹Fe-IONP_pre coated with triethylene glycol was performed in Wistar rats. Following the intravenous administration, high ⁵⁹Fe concentration was observed in the lung and the organs of the reticuloendothelial system such as the liver, the spleen and the femur.

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Title: Preparation and biodistribution of 59Fe-radiolabelled iron oxide nanoparticles
Authors: Martina Pospisilova
Vojtech Zapotocky
Kristina Nesporova
Milan Laznicek
Alice Laznickova
Ondrej Zidek
Martin Cepa
Hana Vagnerova
Vladimir Velebny
Publication date: 01-02-2017
Publisher: Springer Netherlands
Published in: Journal of Nanoparticle Research / Issue 2/2017
Print ISSN: 1388-0764
Electronic ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-016-3719-0

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