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Journal of Materials Science

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01-07-2014

Preparation of alginate–CaCl₂ microspheres as resveratrol carriers

Authors: Ah Ra Cho, Yong Gi Chun, Bum Keun Kim, Dong June Park

Published in: Journal of Materials Science | Issue 13/2014

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Abstract

Resveratrol-loaded calcium alginate microspheres for prolonged drug release were prepared by ionic gelation of alginate with calcium chloride (CaCl₂). Further, resveratrol-loaded calcium alginate microspheres were developed using two concentrations of alginate (0.5 and 1 % w/v) and CaCl₂ (0.5 and 1 M) and an encapsulator equipped with a 300-μm nozzle. The mean particle size of the microspheres was between 175.52 and 244.03 μm, and an encapsulation efficiency (EE) of over 95 % was observed. FTIR spectroscopy indicated a polyelectrolyte interaction between alginate and CaCl₂; alginate microsphere thermograms were analyzed by differential scanning calorimetry. X-ray diffraction shows the crystalline change of microspheres by cross linking. The release profiles and EE increased depending on the CaCl₂ concentration, and a slow initial burst release was observed on freeze-dried microspheres. These results indicate that resveratrol-loaded calcium alginate microspheres can be used as a potential resveratrol delivery system in the food industry.

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Title: Preparation of alginate–CaCl2 microspheres as resveratrol carriers
Authors: Ah Ra Cho
Yong Gi Chun
Bum Keun Kim
Dong June Park
Publication date: 01-07-2014
Publisher: Springer US
Published in: Journal of Materials Science / Issue 13/2014
Print ISSN: 0022-2461
Electronic ISSN: 1573-4803
DOI: https://doi.org/10.1007/s10853-014-8163-x

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