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Published in:
2013 | OriginalPaper | Chapter
Protein-Fatty Acid Conjugate for Self-assembled Nanoparticles in Drug Delivery
Authors : Beom-Jin Lee, Phuong Ha-Lien Tran
Published in: 4th International Conference on Biomedical Engineering in Vietnam
Publisher: Springer Berlin Heidelberg
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Novel biocompatible protein-oleic acid conjugate was prepared to form self-assembled nanoparticles (NP) when exposed to an aqueous medium. The conjugation of protein-fatty acid was confirmed using FTIR and NMR. The physicochemical properties of NP were characterized by the experimental conditions such as pH, temperature and the amount of protein/fatty acid. The self-assembled NP had a uniformly spherical shape with particle size (150-200 nm) and showed good physical stability. This NP had no any potential cellular toxicity. Paclitaxel was chosen as model drug for anti-cancer effect using self-assembled NP. Drug release was controlled over an extended period of time. Furthermore, surface-modified NP using folic acid showed a higher cancer-cell killing effect as compared with Taxol
®
. The
in
vivo
pharmacokinetic parameters and biodistribution of the NP containing paclitaxel also indicated longer blood circulation.