10. Proteins and Macromolecular X-Ray Analysis

In this chapter, we take a more detailed look at methods of X-ray analysis that are particularly applicable to large biological molecules. It will involve some useful reiteration of concepts and ideas discussed in previous chapters. We would also remind readers that although there are definite distinctions between large and small molecules in the crystallographic arena, there is no reason to exclude one from the other, and in fact, there are many advantages in being familiar with both. The major differences should become clearer as we progress through this chapter. It follows that while we deal mainly with macromolecules here, much of the information provided in this chapter is applicable to all areas of crystal structure analysis.