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Published in:
2010 | OriginalPaper | Chapter
Registration of In Vivo Prostate Magnetic Resonance Images to Digital Histopathology Images
Authors : A. D. Ward, C. Crukley, C. McKenzie, J. Montreuil, E. Gibson, J. A. Gomez, M. Moussa, G. Bauman, A. Fenster
Published in: Prostate Cancer Imaging. Computer-Aided Diagnosis, Prognosis, and Intervention
Publisher: Springer Berlin Heidelberg
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Early and accurate diagnosis of prostate cancer enables minimally invasive therapies to cure the cancer with less morbidity. The purpose of this work is to non-rigidly register
in vivo
pre-prostatectomy prostate medical images to regionally-graded histopathology images from post-prostatectomy specimens, seeking a relationship between the multi parametric imaging and cancer distribution and aggressiveness. Our approach uses image-based registration in combination with a magnetically tracked probe to orient the physical slicing of the specimen to be parallel to the
in vivo
imaging planes, yielding a tractable 2D registration problem. We measured a target registration error of 0.85 mm, a mean slicing plane marking error of 0.7 mm, and a mean slicing error of 0.6 mm; these results compare favourably with our 2.2 mm diagnostic MR image thickness. Qualitative evaluation of
in vivo
imaging-histopathology fusion reveals excellent anatomic concordance between MR and digital histopathology.