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2013 | OriginalPaper | Chapter

3. Revisiting Complexation Between DNA and Polyethylenimine: The Effect of Length of Free Polycationic Chains on Gene Transfection

Author : Yue Yanan

Published in: How Free Cationic Polymer Chains Promote Gene Transfection

Publisher: Springer International Publishing

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Abstract

The gene therapy, considered as the treatment of genetically-caused diseases by transferring exogenous nucleic acids into specific cells of patients, has attracted great interests over the past few decades [1]. It has been gradually realized that the development of safe, efficient and controllable gene-delivery vectors has become a bottleneck in clinical applications. The gene transfection vectors can be generally divided as viral and non-viral ones.

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previous chapter Revisiting Complexation Between DNA and Polyethylenimine: The Effect of Uncomplexed Chains Free in the Solution Mixture on Gene Transfection

next chapter Quantitative Comparison of Endocytosis and Intracellular Trafficking of DNA/Polymer Complexes in the Absence/Presence of Free Polycationic Chains

Pack, D. W., Hoffman, A. S., Pun, S., & Stayton, P. S. (2005). Design and development of polymers for gene delivery. Nature Reviews Drug Discovery, 4, 581–593.CrossRef

Li, S. D., & Huang, L. (2007). Non-viral is superior to viral gene delivery. Journal of Controlled Release, 123, 181–183.CrossRef

Mintzer, M. A., & Simanek, E. E. (2009). Nonviral vectors for gene delivery. Chemical Reviews, 109, 259–302.CrossRef

Boussif, O., Lezoualch, F., Zanta, M. A., Mergny, M. D., Scherman, D., Demeneix, B., et al. (1995). A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo-polyethylenimine. Proceedings of the National Academy of Sciences USA, 92, 7297–7301.CrossRef

Lungwitz, U., Breunig, M., Blunk, T., & Gopferich, A. (2005). Polyethylenimine-based non-viral gene delivery systems. European Journal of Pharmaceutics and Biopharmaceutics, 60, 247–266.CrossRef

Neu, M., Fischer, D., & Kissel, T. (2005). Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives. Journal of Gene Medicine, 7, 992–1009.CrossRef

Breunig, M., Lungwitz, U., Liebl, R., & Goepferich, A. (2007). Breaking up the correlation between efficacy and toxicity for nonviral gene delivery. Proceedings of the National Academy of Sciences USA, 104, 14454–14459.CrossRef

Deng, R., Yue, Y., Jin, F., Chen, Y. C., Kung, H. F., Lin, M. C. M., et al. (2009). Revisit the complexation of PEI and DNA—how to make low cytotoxic and highly efficient PEI gene transfection non-viral vectors with a controllable chain length and structure? Journal of Controlled Release, 140, 40–46.CrossRef

Ogris, M., Brunner, S., Schuller, S., Kircheis, R., & Wagner, E. (1999). PEGylated DNA/transferrin–PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery. Gene Therapy, 6, 595–605.CrossRef

10.

Cheng, H., Zhu, J. L., Zeng, X., Jing, Y., Zhang, X. Z., & Zhuo, R. X. (2009). Targeted gene delivery mediated by folate-polyethylenimine-block-poly(ethylene glycol) with receptor selectivity. Bioconjugate Chemistry, 20, 481–487.CrossRef

11.

Zanta, M. A., Boussif, O., Adib, A., & Behr, J. P. (1997). In vitro gene delivery to hepatocytes with galactosylated polyethylenimine. Bioconjugate Chemistry, 8, 839–844.CrossRef

12.

Diebold, S. S., Kursa, P., Wagner, E., Cotten, M., & Zenke, M. (1999). Mannose polyethylenimine conjugates for targeted DNA delivery into dendritic cells. Journal of Biological Chemistry, 274, 19087–19094.CrossRef

13.

Pollard, H., Remy, J. S., Loussouarn, G., Demolombe, S., Behr, J. P., & Escande, D. (1998). Polyethylenimine but not cationic lipids promotes transgene delivery to the nucleus in mammalian cells. Journal of Biological Chemistry, 273, 7507–7511.CrossRef

14.

Godbey, W. T., Wu, K. K., & Mikos, A. G. (1999). Tracking the intracellular path of poly(ethylenimine)/DNA complexes for gene delivery. Proceedings of the National Academy Sciences USA, 96, 5177–5181.CrossRef

15.

Bieber, T., Meissner, W., Kostin, S., Niemann, A., & Elsasser, H. P. (2002). Intracellular route and transcriptional competence of polyethylenimine–DNA complexes. Journal of Controlled Release, 82, 441–454.CrossRef

16.

Thomas, M., & Klibanov, A. M. (2002). Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells. Proceedings of the National Academy Sciences USA, 99, 14640–14645.CrossRef

17.

Sonawane, N. D., Szoka, F. C., & Verkman, A. S. (2003). Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine–DNA polyplexes. Journal of Biological Chemistry, 278, 44826–44831.CrossRef

18.

Suh, J., Wirtz, D., & Hanes, J. (2003). Efficient active transport of gene nanocarriers to the cell nucleus. Proceedings of the National Academy Sciences USA, 100, 3878–3882.CrossRef

19.

Akinc, A., Thomas, M., Klibanov, A. M., & Langer, R. (2005). Exploring polyethylenimine mediated DNA transfection and the proton sponge hypothesis. Journal of Gene Medicine, 7, 657–663.CrossRef

20.

Kulkarni, R. P., Wu, D. D., Davis, M. E., & Fraser, S. E. (2005). Quantitating intracellular transport of polyplexes by spatio-temporal image correlation spectroscopy. Proceedings of the National Academy Sciences USA, 102, 7523–7528.CrossRef

21.

de Bruin, K. G., Fella, C., Ogris, M., Wagner, E., Ruthardt, N., & Brauchle, C. (2008). Dynamics of photoinduced endosomal release of polyplexes. Journal of Controlled Release, 130, 175–182.CrossRef

22.

Gabrielson, N. P., & Pack, D. W. (2009). Efficient polyethylenimine-mediated gene delivery proceeds via a caveolar pathway in HeLa cells. Journal of Controlled Release, 136, 54–61.CrossRef

23.

Won, Y.-Y., Sharma, R., & Konieczny, S. F. (2009). Missing pieces in understanding the intracellular trafficking of polycation/DNA complexes. Journal of Controlled Release, 139, 88–93.CrossRef

24.

Lee, H., Kim, I. K., & Park, T. G. (2010). Intracellular trafficking and unpacking of siRNA/quantum Dot–PEI complexes modified with and without cell penetrating peptide:confocal and flow cytometric FRET analysis. Bioconjugate Chemistry, 21, 289–295.CrossRef

25.

Wagner, E., Cotten, M., Foisner, R., & Birnstiel, M. L. (1991). Transferrin polycation DNA complexes—the effect of polycations on the structure of the complex and DNA delivery to cells. Proceedings of the National Academy Sciences USA, 88, 4255–4259.CrossRef

26.

Godbey, W. T., Wu, K. K., & Mikos, A. G. (1999). Size matters: molecular weight affects the efficiency of poly(ethylenimine) as a gene delivery vehicle. Journal of Biomedical Materials Research, 45, 268–275.CrossRef

27.

Kunath, K., von Harpe, A., Fischer, D., Peterson, H., Bickel, U., Voigt, K., et al. (2003). Lowmolecular-weight polyethylenimine as a non-viral vector for DNA delivery:comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine. Journal of Controlled Release, 89, 113–125.CrossRef

28.

Honore, I., Grosse, S., Frison, N., Favatier, F., Monsigny, M., & Fajac, I. (2005). Transcription of plasmid DNA: influence of plasmid DNA/polyethylenimine complex formation. Journal of Controlled Release, 107, 537–546.CrossRef

29.

Behr, J. P. (1997). The proton sponge: a trick to enter cells the viruses did not exploit. Chimia, 51, 34–36.

30.

Forrest, M. L., Meister, G. E., Koerber, J. T., & Pack, D. W. (2004). Partial acetylation of polyethylenimine enhances in vitro gene delivery. Pharmaceutical Research, 21, 365–371.CrossRef

31.

Yue, Y., Jin, F., Deng, R., Cai, J., Chen, Y., Lin, M. C. M., et al. (2011). Revisit complexation between DNA and polyethylenimine—effect of uncomplexed chains free in the solution mixture on gene transfection. Journal of Controlled Release, 155, 67–76.CrossRef

32.

Clamme, J. P., Azoulay, J., & Mely, Y. (2003). Monitoring of the formation and dissociation of polyethylenimine/DNA complexes by two photon fluorescence correlation spectroscopy. Biophysical Journal, 84, 1960–1968.CrossRef

33.

Clamme, J. P., Krishnamoorthy, G., & Mely, Y. (2003). Intracellular dynamics of the gene delivery vehicle polyethylenimine during transfection: investigation by two photon fluorescence correlation spectroscopy. Biochimica et Biophysica Acta, Biomembranes, 1617, 52–61.CrossRef

34.

Boeckle, S., von Gersdorff, K., van der Piepen, S., Culmsee, C., Wagner, E., & Ogris, M. (2004). Purification of polyethylenimine polyplexes highlights the role of free polycations in gene transfer. Journal of Gene Medicine, 6, 1102–1111.CrossRef

35.

Fahrmeir, J., Gunther, M., Tietze, N., Wagner, E., & Ogris, M. (2007). Electrophoretic purification of tumor-targeted polyethylenimine-based polyplexes reduces toxic side effects in vivo. Journal of Controlled Release, 122, 236–245.CrossRef

36.

Saul, J. M., Wang, C. H. K., Ng, C. P., & Pun, S. H. (2008). Multilayer nanocomplexes of polymer and DNA exhibit enhanced gene delivery. Advanced Materials, 20, 19–25.CrossRef

37.

Chu, B. (1991). Laser light scattering (2nd ed.). New York: Academic Press.

38.

Wu, C., & Xia, K. Q. (1994). Review of Scientific Instruments, 65, 587–590.CrossRef

39.

Berne, B., & Pecora, R. (1976). Dynamic light scattering. New York: Plenum Press.

40.

Hunter, R. J. (2000). Foundations of colloid science (2nd ed.). Oxford: Oxford Press.

41.

Forrest, M. L., & Pack, D. W. (2002). On the kinetics of polyplex endocytic trafficking:implications for gene delivery vector design. Molecular Therapy, 6, 57–66.CrossRef

42.

Breunig, M., Lungwitz, U., Liebl, R., Fontanari, C., Klar, J., Kurtz, A., et al. (2005). Gene delivery with low molecular weight linear polyethytenimines. Journal of Gene Medicine, 7, 1287–1298.CrossRef

43.

Akinc, A. (2002). Measuring the pH environment of DNA delivered using nonviral vectors: implications for lysosomal trafficking. Biotechnology Bioengineering, 78, 503–508.CrossRef

44.

Peng, S. F., & Wu, C. (1999). Light scattering study of the formation and structure of partially hydrolyzed poly(acrylamide)/calcium(II) complexes. Macromolecules, 32, 585–589.CrossRef

45.

Zhang, G. Z., & Wu, C. (2006). Folding and formation of mesoglobules in dilute copolymer solutions. Advances in Polymer Science, 195, 101–176.CrossRef

46.

Rejman, J., Bragonzi, A., & Conese, M. (2005). A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy. Molecular Therapy, 12, 468–474.CrossRef

47.

Itaka, K., Harada, A., Yamasaki, Y., Nakamura, K., Kawaguchi, H., & Kataoka, K. (2004). In situ single cell observation by fluorescence resonance energy transfer reveals fastintra-cytoplasmic delivery and easy release of plasmid DNA complexed with linear polyethylenimine. Journal Gene Medicine, 6, 76–84.CrossRef

48.

Bertschinger, M., Backliwal, G., Schertenleib, A., Jordan, M., Hacker, D. L., & Wurm, F. M. (2006). Disassembly of polyethylenimine–DNA particles in vitro: implications for polyethylenimine-mediated DNA delivery. Journal of Controlled Release, 116, 96–104.CrossRef

49.

Bowman, E. J., Siebers, A., & Altendorf, K. (1988). Bafilomycins—a class of inhibitors of membrane Atpases from microorganisms, animal-cells, and plant-cells. Proceedings of the National Academy of Sciences USA, 85, 7972–7976.CrossRef

50.

Crider, B. P., Xie, X. S., & Stone, D. K. (1994). Bafilomycin inhibits proton flow-through the H+ channel of vacuolar proton pumps. Journal of Biological Chemistry, 269, 17379–17381.

51.

Pichon, C., Roufai, M. B., Monsigny, M., & Midoux, P. (2000). Histidylated oligolysines increase the transmembrane passage and the biological activity of antisense oligonucleotides. Nucleic Acids Research, 28, 504–512.CrossRef

52.

Wang, D. A., Narang, A. S., Kotb, M., Gaber, A. O., Miller, D. D., Kim, S. W., et al. (2002). Novel branched poly(ethylenimine)-cholesterol water-soluble lipopolymers for gene delivery. Biomacromolecules, 3, 1197–1207.CrossRef

53.

Neamnark, A., Suwantong, O., Bahadur, K. C. R., Hsu, C. Y. M., Supaphol, P., & Uludag, H. (2009). Aliphatic lipid substitution on 2 kDa polyethylenimine improves plasmid delivery and transgene expression. Molecular Pharmaceutics, 6, 1798–1815.CrossRef

Title: Revisiting Complexation Between DNA and Polyethylenimine: The Effect of Length of Free Polycationic Chains on Gene Transfection
Author: Yue Yanan
Publisher: Springer International Publishing
Book: How Free Cationic Polymer Chains Promote Gene Transfection
Print ISBN: 978-3-319-00335-1

Electronic ISBN: 978-3-319-00336-8

Copyright Year: 2013
DOI: https://doi.org/10.1007/978-3-319-00336-8_3

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