2005 | OriginalPaper | Chapter
Robust Tissue Boundary Detection for Cerebral Cortical Thickness Estimation
Authors : Marietta L. J. Scott, Neil A. Thacker
Published in: Medical Image Computing and Computer-Assisted Intervention – MICCAI 2005
Publisher: Springer Berlin Heidelberg
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This paper presents an algorithm for determining regional cerebral grey matter cortical thickness from magnetic resonance scans. In particular, the modification of a gradient-based edge detector into an iso-grey-level boundary detector for reliably determining the low-contrast grey-white matter interface is described and discussed. The reproducibility of the algorithm over 31 gyral regions is assessed using repeat scans of four subjects, and a technique for correcting the misplacement of the grey-white matter boundary is shown to significantly reduce the systematic error on the reproducibility.