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A Wearable Hand Neuroprosthesis for Hand Rehabilitation After Stroke: Preliminary Results of the RETRAINER S2 Randomized Controlled Trial Read chapter Read first chapter

2019 | OriginalPaper | Chapter

Role of Renshaw Cells in the Mammalian Locomotor Circuit: A Computational Study

Authors : Priscilla Corsi, Emanuele Formento, Marco Capogrosso, Silvestro Micera

Published in: Converging Clinical and Engineering Research on Neurorehabilitation III

Publisher: Springer International Publishing

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Abstract

In this study we considered the role of the inhibitory interneurons known as Renshaw cells (RC) in the activity of a simulated locomotor neural network. We used a n integrate-and fire-model to reproduce RCs experimental three-phases responses, consisting of a fast activation, a relaxation time and a slow activation. Simulations of RCs within a model of muscle spindle reflex neural network highlighted multiple roles of Renshaw cells in locomotion. We found that RCs synchronize the pool of motor neurons (MNs) they act on, and regulate the relative duration of the antagonist muscle bursts during the gait cycle. This refined model can be used to simulate the interaction between electrodes and spinal circuits to improve the efficacy of spinal cord stimulation protocols.

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previous chapter Progress Towards the Development of the DeTOP Hand Prosthesis: A Sensorized Transradial Prosthesis for Clinical Use
next chapter Development of an Intraneural Peripheral Stimulation Paradigm for the Restoration of Fine Hand Control in Non-human Primates
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Metadata
Title
Role of Renshaw Cells in the Mammalian Locomotor Circuit: A Computational Study
Authors
Priscilla Corsi
Emanuele Formento
Marco Capogrosso
Silvestro Micera
Copyright Year
2019
Book
Converging Clinical and Engineering Research on Neurorehabilitation III

Print ISBN: 978-3-030-01844-3

Electronic ISBN: 978-3-030-01845-0

Copyright Year: 2019

DOI
https://doi.org/10.1007/978-3-030-01845-0_21