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2015 | OriginalPaper | Chapter

Sialic Acid Receptors of Viruses

Authors : Mikhail Matrosovich, Georg Herrler, Hans Dieter Klenk

Published in: SialoGlyco Chemistry and Biology II

Publisher: Springer International Publishing

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Abstract

Sialic acid linked to glycoproteins and gangliosides is used by many viruses as a receptor for cell entry. These viruses include important human and animal pathogens, such as influenza, parainfluenza, mumps, corona, noro, rota, and DNA tumor viruses. Attachment to sialic acid is mediated by receptor binding proteins that are constituents of viral envelopes or exposed at the surface of non-enveloped viruses. Some of these viruses are also equipped with a neuraminidase or a sialyl-O-acetyl-esterase. These receptor-destroying enzymes promote virus release from infected cells and neutralize sialic acid-containing soluble proteins interfering with cell surface binding of the virus. Variations in the receptor specificity are important determinants for host range, tissue tropism, pathogenicity, and transmissibility of these viruses.

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next chapter Endosialidases: Versatile Tools for the Study of Polysialic Acid

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Title: Sialic Acid Receptors of Viruses
Authors: Mikhail Matrosovich
Georg Herrler
Hans Dieter Klenk
Publisher: Springer International Publishing
Book: SialoGlyco Chemistry and Biology II
Print ISBN: 978-3-319-21316-3

Electronic ISBN: 978-3-319-21317-0

Copyright Year: 2015
DOI: https://doi.org/10.1007/128_2013_466