Skip to main content
Top
Published in: Journal of Nanoparticle Research 2/2012

01-02-2012 | Research Paper

Silica encapsulation of luminescent silicon nanoparticles: stable and biocompatible nanohybrids

Authors: Vincent Maurice, Ilaria Rivolta, Julien Vincent, Olivier Raccurt, Jean-Noel Rouzaud, Giuseppe Miserrochi, Eric Doris, Cécile Reynaud, Nathalie Herlin-Boime

Published in: Journal of Nanoparticle Research | Issue 2/2012

Log in

Activate our intelligent search to find suitable subject content or patents.

search-config
loading …

Abstract

This article presents a process for surface coating and functionalization of luminescent silicon nanoparticles. The particles were coated with silica using a microemulsion process that was adapted to the fragile silicon nanoparticles. The as-produced core–shell particles have a mean diameter of 35 nm and exhibit the intrinsic photoluminescence of the silicon core. The silica layer protects the core from aqueous oxidation for several days, thus allowing the use of the nanoparticles for biological applications. The nanoparticles were further coated with amines and functionalized with polyethylene glycol chains and the toxicity of the particles has been evaluated at the different stages of the process. The core–shell nanoparticles exhibit no acute toxicity towards lung cells, which is promising for further development.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Appendix
Available only for authorised users
Literature
go back to reference Arriagada FJ, Osseo-Asare K (1999) Synthesis of nanosize silica in a nonionic water-in-oil microemulsion: effects of the water/surfactant molar ratio and ammonia concentration. J Colloid Interface Sci 211:210–220CrossRef Arriagada FJ, Osseo-Asare K (1999) Synthesis of nanosize silica in a nonionic water-in-oil microemulsion: effects of the water/surfactant molar ratio and ammonia concentration. J Colloid Interface Sci 211:210–220CrossRef
go back to reference Bagwe RP, Yang C, Hilliard LR, Tan W (2004) Optimization of dye-doped silica nanoparticles prepared using a reverse microemulsion method. Langmuir 20:8336–8342CrossRef Bagwe RP, Yang C, Hilliard LR, Tan W (2004) Optimization of dye-doped silica nanoparticles prepared using a reverse microemulsion method. Langmuir 20:8336–8342CrossRef
go back to reference Bagwe RP, Hilliard LR, Tan W (2006) Surface modification of silica nanoparticles to reduce aggregation and nonspecific binding. Langmuir 22:4357–4362CrossRef Bagwe RP, Hilliard LR, Tan W (2006) Surface modification of silica nanoparticles to reduce aggregation and nonspecific binding. Langmuir 22:4357–4362CrossRef
go back to reference Best SA, Merz KM Jr, Reynolds CH (1997) GB/SA-based continuum solvation model for octanol. J Phys Chem B 101:10479–10487CrossRef Best SA, Merz KM Jr, Reynolds CH (1997) GB/SA-based continuum solvation model for octanol. J Phys Chem B 101:10479–10487CrossRef
go back to reference Blum AS, Moore MH, Ratna BR (2008) Quantum dot fluorescence as a function of alkyl chain length in aqueous environments. Langmuir 24:9194–9197CrossRef Blum AS, Moore MH, Ratna BR (2008) Quantum dot fluorescence as a function of alkyl chain length in aqueous environments. Langmuir 24:9194–9197CrossRef
go back to reference Bomatí-Miguel O, Tartaj P, Morales MP, Bonville P, Golla-Schindler U, Zhao XQ, Veintemillas-Verdaguer S (2006) Core–shell iron–iron oxide nanoparticles synthesized by laser-induced pyrolysis. Small 2:1476–1483CrossRef Bomatí-Miguel O, Tartaj P, Morales MP, Bonville P, Golla-Schindler U, Zhao XQ, Veintemillas-Verdaguer S (2006) Core–shell iron–iron oxide nanoparticles synthesized by laser-induced pyrolysis. Small 2:1476–1483CrossRef
go back to reference Borsella E, Botti S, Cremona M, Martelli S, Montereali RM, Nesterenko A (1997) Photoluminescence from oxidised Si nanoparticles produced by CW Co2 laser synthesis in a continuous-flow reactor. J Mater Sci Lett 16:221CrossRef Borsella E, Botti S, Cremona M, Martelli S, Montereali RM, Nesterenko A (1997) Photoluminescence from oxidised Si nanoparticles produced by CW Co2 laser synthesis in a continuous-flow reactor. J Mater Sci Lett 16:221CrossRef
go back to reference Botto L, Beretta E, Bulbarelli A, Rivolta I, Lettiero B, Leone BE, Miserocchi G, Palestini P (2008) Hypoxia-induced modifications in plasma membranes and lipid microdomains in A549 cells and primary human alveolar cells. J Cell Biochem 105:503–513CrossRef Botto L, Beretta E, Bulbarelli A, Rivolta I, Lettiero B, Leone BE, Miserocchi G, Palestini P (2008) Hypoxia-induced modifications in plasma membranes and lipid microdomains in A549 cells and primary human alveolar cells. J Cell Biochem 105:503–513CrossRef
go back to reference Cannon WR, Danforth SC, Flint JH, Haggerty JS, Marra RA (1982) Sinterable ceramic powders from laser-driven reactions: I, process description and modeling. J Am Ceram Soc 65:324–330CrossRef Cannon WR, Danforth SC, Flint JH, Haggerty JS, Marra RA (1982) Sinterable ceramic powders from laser-driven reactions: I, process description and modeling. J Am Ceram Soc 65:324–330CrossRef
go back to reference Cullis AG, Canham LT, Calcott PDJ (1997) The structural and luminescence properties of porous silicon. J Appl Phys 82:909–966CrossRef Cullis AG, Canham LT, Calcott PDJ (1997) The structural and luminescence properties of porous silicon. J Appl Phys 82:909–966CrossRef
go back to reference Dantelle G, Rondin L, Slablab A, Lainé F, Carrel F, Bergonzo P, Perruchas S, Gacoin T, Treussart F, Roch J-F (2010) Efficient production of NV colour centres in nanodiamonds using high-energy electron irradiation. J Lumin 130:1655CrossRef Dantelle G, Rondin L, Slablab A, Lainé F, Carrel F, Bergonzo P, Perruchas S, Gacoin T, Treussart F, Roch J-F (2010) Efficient production of NV colour centres in nanodiamonds using high-energy electron irradiation. J Lumin 130:1655CrossRef
go back to reference Denyer SP (1995) Mechanisms of action of antibacterial biocides. Int Biodeterior Biodegrad 36:227–245CrossRef Denyer SP (1995) Mechanisms of action of antibacterial biocides. Int Biodeterior Biodegrad 36:227–245CrossRef
go back to reference Derfus AM, Chan WCW, Bhatia SN (2004) Probing the cytotoxicity of semiconductor quantum dots. Nano Lett 4:11–18CrossRef Derfus AM, Chan WCW, Bhatia SN (2004) Probing the cytotoxicity of semiconductor quantum dots. Nano Lett 4:11–18CrossRef
go back to reference Ehbrecht M, Kohn B, Huisken F, Laguna MA, Paillard V (1997) Photoluminescence and resonant Raman spectra of silicon films produced by size-selected cluster beam deposition. Phys Rev B 56:6958–6964CrossRef Ehbrecht M, Kohn B, Huisken F, Laguna MA, Paillard V (1997) Photoluminescence and resonant Raman spectra of silicon films produced by size-selected cluster beam deposition. Phys Rev B 56:6958–6964CrossRef
go back to reference Erogbogbo F, Yong K, Roy I, Xu GX, Prasad PN, Swihart MT (2008) Biocompatible luminescent silicon quantum dots for imaging of cancer cells. ACS Nano 2:873–878CrossRef Erogbogbo F, Yong K, Roy I, Xu GX, Prasad PN, Swihart MT (2008) Biocompatible luminescent silicon quantum dots for imaging of cancer cells. ACS Nano 2:873–878CrossRef
go back to reference Erogbogbo F, Yong KT, Hu R, Law WC, Ding H, Chang CW, Prasad PN, Swihart MT (2010) Biocompatible magnetofluorescent probes: luminescent silicon quantum dots coupled with superparamagnetic iron(iii) oxide. ACS Nano 4:5131CrossRef Erogbogbo F, Yong KT, Hu R, Law WC, Ding H, Chang CW, Prasad PN, Swihart MT (2010) Biocompatible magnetofluorescent probes: luminescent silicon quantum dots coupled with superparamagnetic iron(iii) oxide. ACS Nano 4:5131CrossRef
go back to reference Ganguli AK, Ganguly A, Vaidya S (2010) Microemulsion-based synthesis of nanocrystalline materials. Chem Soc Rev 39:474–485CrossRef Ganguli AK, Ganguly A, Vaidya S (2010) Microemulsion-based synthesis of nanocrystalline materials. Chem Soc Rev 39:474–485CrossRef
go back to reference Giaume D, Buissette V, Lahlil K, Gacoin T, Boilot J-P, Casanova D, Beaurepaire E, Sauviat M-P, Alexandrou A (2005) Emission properties and applications of nanostructured luminescent oxide nanoparticles. Prog Solid State Chem 33:99–106CrossRef Giaume D, Buissette V, Lahlil K, Gacoin T, Boilot J-P, Casanova D, Beaurepaire E, Sauviat M-P, Alexandrou A (2005) Emission properties and applications of nanostructured luminescent oxide nanoparticles. Prog Solid State Chem 33:99–106CrossRef
go back to reference He Y, Su Y, Yang X, Kang Z, Xu T, Zhang R, Fan C, Lee ST (2009) Photo and pH stable, highly-luminescent silicon nanospheres and their bioconjugates for immunofluorescent cell imaging. J Am Chem Soc 131:4434–4438CrossRef He Y, Su Y, Yang X, Kang Z, Xu T, Zhang R, Fan C, Lee ST (2009) Photo and pH stable, highly-luminescent silicon nanospheres and their bioconjugates for immunofluorescent cell imaging. J Am Chem Soc 131:4434–4438CrossRef
go back to reference Hua F, Swihart MT, Ruckenstein E (2005) Efficient surface grafting of luminescent silicon quantum dots by photoinitiated hydrosilylation. Langmuir 21:6054–6062CrossRef Hua F, Swihart MT, Ruckenstein E (2005) Efficient surface grafting of luminescent silicon quantum dots by photoinitiated hydrosilylation. Langmuir 21:6054–6062CrossRef
go back to reference Huhtala A, Pohjonen T, Salminen L, Salminen A, Kaarniranta K, Uusitalo H (2007) In vitro biocompatibility of degradable biopolymers in cell line cultures from various ocular tissues: direct contact studies. J Biomed Mater Res A 83:407–413 Huhtala A, Pohjonen T, Salminen L, Salminen A, Kaarniranta K, Uusitalo H (2007) In vitro biocompatibility of degradable biopolymers in cell line cultures from various ocular tissues: direct contact studies. J Biomed Mater Res A 83:407–413
go back to reference Klostranec JM, Chan WCW (2006) Quantum dots in biological and biomedical research recent progress and present challenges. Adv Mater 18:1953–1964CrossRef Klostranec JM, Chan WCW (2006) Quantum dots in biological and biomedical research recent progress and present challenges. Adv Mater 18:1953–1964CrossRef
go back to reference Lacour F, Guillois O, Portier X, Perez H, Herlin N, Reynaud C (2007) Laser pyrolysis synthesis and characterization of luminescent silicon nanocrystals. Physica E 38:11–15CrossRef Lacour F, Guillois O, Portier X, Perez H, Herlin N, Reynaud C (2007) Laser pyrolysis synthesis and characterization of luminescent silicon nanocrystals. Physica E 38:11–15CrossRef
go back to reference Ledoux G, Guillois O, Porterat D, Reynaud C, Huisken F, Kohn B, Paillard V (2000) Photoluminescence properties of silicon nanocrystals as a function of their size. Phys Rev B 62:15942CrossRef Ledoux G, Guillois O, Porterat D, Reynaud C, Huisken F, Kohn B, Paillard V (2000) Photoluminescence properties of silicon nanocrystals as a function of their size. Phys Rev B 62:15942CrossRef
go back to reference Li ZF, Ruckenstein E (2004) Water-soluble poly(acrylic acid) grafted luminescent silicon nanoparticles and their use as fluorescent biological staining labels. Nano Lett 4:1463–1467CrossRef Li ZF, Ruckenstein E (2004) Water-soluble poly(acrylic acid) grafted luminescent silicon nanoparticles and their use as fluorescent biological staining labels. Nano Lett 4:1463–1467CrossRef
go back to reference Li X, He Y, Talukdar SS, Swihart MT (2003) Process for preparing macroscopic quantities of brightly photoluminescent silicon nanoparticles with emission spanning the visible spectrum. Langmuir 19:8490–8496CrossRef Li X, He Y, Talukdar SS, Swihart MT (2003) Process for preparing macroscopic quantities of brightly photoluminescent silicon nanoparticles with emission spanning the visible spectrum. Langmuir 19:8490–8496CrossRef
go back to reference Li X, He Y, Swihart MT (2004) Surface functionalization of silicon nanoparticles produced by laser-driven pyrolysis of silane followed by HF-HNO3 etching. Langmuir 20:4720–4727CrossRef Li X, He Y, Swihart MT (2004) Surface functionalization of silicon nanoparticles produced by laser-driven pyrolysis of silane followed by HF-HNO3 etching. Langmuir 20:4720–4727CrossRef
go back to reference Mangolini L, Thimsen E, Kortshagen U (2005) High-yield plasma synthesis of luminescent silicon nanocrystals. Nano Lett 5:655–659CrossRef Mangolini L, Thimsen E, Kortshagen U (2005) High-yield plasma synthesis of luminescent silicon nanocrystals. Nano Lett 5:655–659CrossRef
go back to reference Meyers SR, Juhn FS, Griset AP, Luman NR, Grinstaff NW (2008) Anionic amphiphilic dendrimers as antibacterial agents. J Am Chem Soc 130:14444–14445CrossRef Meyers SR, Juhn FS, Griset AP, Luman NR, Grinstaff NW (2008) Anionic amphiphilic dendrimers as antibacterial agents. J Am Chem Soc 130:14444–14445CrossRef
go back to reference Pignon B, Maskrot H, Leconte Y, Reynaud C, Herlin-Boime N, Guyot Ferreol V, Pouget T, Tranchant JF, Gervais M, Coste S (2008) Versatility of laser pyrolysis applied to the synthesis of TiO2 nanoparticles—application to UV attenuation. Eur J Inorg Chem 2008:883–889CrossRef Pignon B, Maskrot H, Leconte Y, Reynaud C, Herlin-Boime N, Guyot Ferreol V, Pouget T, Tranchant JF, Gervais M, Coste S (2008) Versatility of laser pyrolysis applied to the synthesis of TiO2 nanoparticles—application to UV attenuation. Eur J Inorg Chem 2008:883–889CrossRef
go back to reference Shenderova OA, Zhirnov VV, Brenner DW (2002) Carbon nanostructures. Crit Rev Solid State Mater Sci 27:227CrossRef Shenderova OA, Zhirnov VV, Brenner DW (2002) Carbon nanostructures. Crit Rev Solid State Mater Sci 27:227CrossRef
go back to reference Spanhel L, Haase M, Weller H, Henglein A (1987) Photochemistry of colloidal semiconductors. 20. Surface modification and stability of strong luminescing CdS particles. J Am Chem Soc 109:5649–5655CrossRef Spanhel L, Haase M, Weller H, Henglein A (1987) Photochemistry of colloidal semiconductors. 20. Surface modification and stability of strong luminescing CdS particles. J Am Chem Soc 109:5649–5655CrossRef
go back to reference Sublemontier O, Lacour F, Leconte Y, Herlin-Boime N, Reynaud C (2009) Co2 laser-driven pyrolysis synthesis of silicon nanocrystals and applications. J Alloys Compd 483:499–502CrossRef Sublemontier O, Lacour F, Leconte Y, Herlin-Boime N, Reynaud C (2009) Co2 laser-driven pyrolysis synthesis of silicon nanocrystals and applications. J Alloys Compd 483:499–502CrossRef
go back to reference Vincent J, Maurice V, Paquez X, Sublemontier O, Leconte Y, Guillois O, Reynaud C, Herlin-Boime N, Raccurt O, Tardif F (2010) Effect of water and UV passivation on the luminescence of suspensions of silicon quantum dots. J Nanopart Res 12:39–46CrossRef Vincent J, Maurice V, Paquez X, Sublemontier O, Leconte Y, Guillois O, Reynaud C, Herlin-Boime N, Raccurt O, Tardif F (2010) Effect of water and UV passivation on the luminescence of suspensions of silicon quantum dots. J Nanopart Res 12:39–46CrossRef
go back to reference Voicu I, Armand X, Cauchetier M, Herlin N, Bourcier S (1996) Laser synthesis of fullerenes from benzene–oxygen mixtures. Chem Phys Lett 256:261CrossRef Voicu I, Armand X, Cauchetier M, Herlin N, Bourcier S (1996) Laser synthesis of fullerenes from benzene–oxygen mixtures. Chem Phys Lett 256:261CrossRef
go back to reference Wang F, Tan WB, Zhang Y, Fan X, Wang M (2006) Luminescent nanomaterials for biological labelling. Nanotechnology 17:R1–R13CrossRef Wang F, Tan WB, Zhang Y, Fan X, Wang M (2006) Luminescent nanomaterials for biological labelling. Nanotechnology 17:R1–R13CrossRef
go back to reference Wang Q, Ni H, Pietzsch A, Hennies F, Bao Y, Chao Y (2011) Synthesis of water-dispersible photoluminescent silicon nanoparticles and their use in biological fluorescent imaging. J Nanopart Res 13:405–413CrossRef Wang Q, Ni H, Pietzsch A, Hennies F, Bao Y, Chao Y (2011) Synthesis of water-dispersible photoluminescent silicon nanoparticles and their use in biological fluorescent imaging. J Nanopart Res 13:405–413CrossRef
go back to reference Warner JH, Hoshino A, Yamamoto K, Tilley RD (2005) Water-soluble photoluminescent silicon quantum dots. Angew Chem Int Ed Engl 44:4550–4554CrossRef Warner JH, Hoshino A, Yamamoto K, Tilley RD (2005) Water-soluble photoluminescent silicon quantum dots. Angew Chem Int Ed Engl 44:4550–4554CrossRef
go back to reference Yao L, Xu G, Dou W, Bai Y (2008) The control of size and morphology of nanosized silica in Triton X-100 based reverse micelle. Colloids Surf A: Physicochem Eng Aspects 316:8–14CrossRef Yao L, Xu G, Dou W, Bai Y (2008) The control of size and morphology of nanosized silica in Triton X-100 based reverse micelle. Colloids Surf A: Physicochem Eng Aspects 316:8–14CrossRef
go back to reference Yoffe AD (1993) Low-dimensional systems: quantum size effects and electronic properties of semiconductor microcrystallites (zero-dimensional systems) and some quasi-two-dimensional systems. Adv Phys 42:173–262CrossRef Yoffe AD (1993) Low-dimensional systems: quantum size effects and electronic properties of semiconductor microcrystallites (zero-dimensional systems) and some quasi-two-dimensional systems. Adv Phys 42:173–262CrossRef
Metadata
Title
Silica encapsulation of luminescent silicon nanoparticles: stable and biocompatible nanohybrids
Authors
Vincent Maurice
Ilaria Rivolta
Julien Vincent
Olivier Raccurt
Jean-Noel Rouzaud
Giuseppe Miserrochi
Eric Doris
Cécile Reynaud
Nathalie Herlin-Boime
Publication date
01-02-2012
Publisher
Springer Netherlands
Published in
Journal of Nanoparticle Research / Issue 2/2012
Print ISSN: 1388-0764
Electronic ISSN: 1572-896X
DOI
https://doi.org/10.1007/s11051-011-0697-0

Other articles of this Issue 2/2012

Journal of Nanoparticle Research 2/2012 Go to the issue

Premium Partners