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International Journal of Plastics Technology

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17-10-2018 | Research Article

Site-specific tunable drug release from biocompatible tragacanth-cl-polyacrylamide polymer networks

Authors: Vikrant Sharma, Jogindra Devi

Published in: International Journal of Plastics Technology | Issue 2/2018

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Abstract

In present study, tragacanth gum-based pH-responsive tunable drug delivery devices have been synthesized. The relation between synthetic reaction parameters during polymerization reaction and swelling and drug release from polymers has also been studied. Polymers were characterized by FTIR, blood compatibility and swelling studies. Swelling of TG-cl-poly(AAm) polymers decreased with an increase in feed monomer [AAm] and cross-linker [NN-MBA] concentration. Polymer showed pH-responsive swelling nature as swelling increased with an increase in pH of solution. The swelling and drug release occurred through non-Fickian diffusion mechanism and release profile obey Korsmeyer–Peppas model of drug release. There is no rapid increase in drug release rate from drug-loaded polymers which is a required characteristic for controlled drug delivery system. TG-cl-poly(AAm) polymers are found to be non-thrombogenic, haemo-compatible during blood-compatibility studies. These polysaccharide based polymers can be tailored for developing site-specific biocompatible delivery devices to enhance local and systemic bioavailability of loaded curative agents.

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Title: Site-specific tunable drug release from biocompatible tragacanth-cl-polyacrylamide polymer networks
Authors: Vikrant Sharma
Jogindra Devi
Publication date: 17-10-2018
Publisher: Springer India
Published in: International Journal of Plastics Technology / Issue 2/2018
Print ISSN: 0972-656X
Electronic ISSN: 0975-072X
DOI: https://doi.org/10.1007/s12588-018-9218-7

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