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2013 | OriginalPaper | Chapter

Spatial Aspects of HIV Infection

Authors : Frederik Graw, Alan S. Perelson

Published in: Mathematical Methods and Models in Biomedicine

Publisher: Springer New York

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Abstract

Human immunodeficiency virus type 1 (HIV-1) is one of the most and intensely studied viral pathogens in the history of science. However, despite the huge scientific effort, many aspects of HIV infection dynamics and disease pathogenesis within a host are still not understood. Mathematical modeling has helped to improve our understanding of the infection as well as the dynamics of the immune response. Fitting models to clinical data has provided estimates for the turnover rate of target cells [82, 83,111], the lifetime of infected cells and viral particles [104, 109], as well as for the rate of viral production by infected cells [21, 44]. Most mathematical models applied to experimental data on viral infections have been formulated as systems of ordinary differential equations (ODE) [91, 101, 104].

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next chapter Basic Principles in Modeling Adaptive Regulation and Immunodominance
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Metadata
Title
Spatial Aspects of HIV Infection
Authors
Frederik Graw
Alan S. Perelson
Copyright Year
2013
Publisher
Springer New York
Book
Mathematical Methods and Models in Biomedicine

Print ISBN: 978-1-4614-4177-9

Electronic ISBN: 978-1-4614-4178-6

Copyright Year: 2013

DOI
https://doi.org/10.1007/978-1-4614-4178-6_1

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