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Published in:
2012 | OriginalPaper | Chapter
Superparamagnetic Iron Oxide Nanoparticles: Evaluation of Stability of SPIONs in Different Milieu for Magnetic Particle Imaging
Authors : Kerstin Lüdtke-Buzug, Céline Borchers
Published in: Magnetic Particle Imaging
Publisher: Springer Berlin Heidelberg
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Today, a variety of different nanoparticles are used in various applications. In particular, super-paramagnetic iron oxide nanoparticles (or SPIONs) are used
in
vitro
for cell separation and
in
vivo
for hyperthermia or as contrast agent for magnetic resonance imaging (MRI). However, in Magnetic Particle Imaging (MPI), SPIONs play a fundamental role as tracer material. In addition to the overall size of the particles and the particle coating, which are important for medical applications, it is the magnetic core diameter that is relevant for the performance in MPI applications. In general, for
in
vivo
applications, the stability of the particles is of key importance. Therefore, in this paper, the stability of the SPIONs have been analyzed in different particle suspension media.