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Journal of Materials Science
Published in: Journal of Materials Science 16/2017

03-05-2017 | Biomaterials

Superparamagnetic nanohybrids with cross-linked polymers providing higher in vitro stability

Authors: Weerakanya Maneeprakorn, Lionel Maurizi, Hathainan Siriket, Tuksadon Wutikhun, Tararaj Dharakul, Heinrich Hofmann

Published in: Journal of Materials Science | Issue 16/2017

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Abstract

A simple, rapid, reproducible, and scalable method for generating highly stable cross-linked superparamagnetic nanohybrids was developed. Pre-coating of superparamagnetic iron oxide nanoparticle surfaces with a biocompatible polymer, hydroxy polyvinyl alcohol (PVA-OH) prior to cross-linking with silica precursor resulted in improved stability, uniform morphologies and allows for further surface functionalization. The obtained magnetic nanohybrids contain a non-porous silica layer, are monodisperse (size 50.0 ± 3.7 nm), and show colloidal stability applicable for biomedical applications (pH 7.35–7.45) with long shelf life (>9 months). In vitro studies indicate that as-prepared nanohybrids are non-cytotoxic and highly robust toward endosomal/lysosomal conditions, with no particle dissolution evident for up to 42 days. As a demonstration of the potential utility of these nanohybrids in medical diagnostic applications (e.g., MRI), surface functionalization with folic acid resulted in particle recognition and affinity to folate receptor-positive cervix (HeLa) cells. Accordingly, the facile development of these non-toxic, stable cross-linked magnetic nanohybrids, with the added benefit of scalable preparation, should serve as an entry point for the further development of safer, target specific, MRI contrast agents for cancer diagnosis.
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Appendix
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Metadata
Title
Superparamagnetic nanohybrids with cross-linked polymers providing higher in vitro stability
Authors
Weerakanya Maneeprakorn
Lionel Maurizi
Hathainan Siriket
Tuksadon Wutikhun
Tararaj Dharakul
Heinrich Hofmann
Publication date
03-05-2017
Publisher
Springer US
Published in
Journal of Materials Science / Issue 16/2017
Print ISSN: 0022-2461
Electronic ISSN: 1573-4803
DOI
https://doi.org/10.1007/s10853-017-1098-2

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