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Journal of Polymer Research

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01-09-2011 | Original Paper

Synthesis and characterisation of porous polymer microneedles

Authors: Laith Humrez, Maximiano Ramos, Ahmed Al-Jumaily, Mira Petchu, John Ingram

Published in: Journal of Polymer Research | Issue 5/2011

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Abstract

This paper presents a study on the synthesis of porous polymers with an application to microneedles. A range of Poly (ethylene glycol-co-methacrylic acid) polymers are synthesised using bulk polymerisation techniques to produce porous polymers with various strength and fluid transport characteristics. The synthesised materials are morphologically and mechanically characterised. Using different porogens in the polymer synthesis results in different mechanical strength and fluid flow characteristics. The results indicate that the fluid flow characteristics of the polymers can be sacrificed to improve strength. Optimum polymer strength can be attained by synthesising polymers with macropores that are interconnected via nanopores using the minimum amount of porogenic solvents.

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Barry BW (2001) Eur J Pharm Sci 14(2):101–114CrossRef

McAllister DV, Allen MG, Prausnitz MR (2000) Annu Rev Biomed Eng 2:289–313CrossRef

Kaushik S, Hord AH, Denson DD, McAllister DV, Smitra S, Allen MG, Prausnitz MR (2001) Anesth Analg 92(2):502–504CrossRef

Prausnitz MR (2004) Adv Drug Deliv Rev 56:581–587CrossRef

Al-Qallaf B, Das DB, Mori D, Cui ZF (2007) Philos T Roy Soc A 365:2951–2967CrossRef

McAllister DV (2003) Proc Natl Acad Sci USA 100(24):13755–13760CrossRef

Al-Qallaf B, Das DB (2009) Ann NY Acad Sci 1161:83–94CrossRef

Al-Qallaf B, Das DB (2009) J Drug Target 17(2):108–122CrossRef

Al-Qallaf B, Das DB, Davidson A (2009) Asia Pac J Chem Eng 4(6):845–857CrossRef

10.

Chakraborty S, Tsuchiya K (2008) J Appl Phys 103(11):114701–114709CrossRef

11.

Park JH, Allen MG, Prausnitz MR (2005) J Control Release 104(1):51–66CrossRef

12.

Hile DD, Pishko MV (2004) Drug Deliv 11:287–293CrossRef

13.

Mooney DJ, Baldwin DF, Suh NP, Vacanti JP, Langer R (1996) Biomaterials 17(14):1417–1422CrossRef

14.

Park JH, Choi S, Kamath R, Yoon YK, Allen MG, Prausnitz MR (2007) Biomed Microdevices 9(2):223–234CrossRef

15.

Brandrup J, Immergut EH, Grulke EA (eds) (1999) Polymer handbook, 4th edition. John Wiley, New York

16.

Deleuze H, Schultze X, Sherrington DC (2000) Polym Bull 44(2):179–186CrossRef

17.

Yu C, Xu M, Svec F, Fréchet JMJ (2002) J Polym Sci Part Polym Chem 40(6):755–769CrossRef

18.

Stevens M (1999) Polymer chemistry, An introduction, 3rd edition. Oxford University Press, New York

19.

Zeleniakiene DKT, Liukaitis J, Marazas G (2003) Material Science 9(4):358–362

20.

Xie S, Allington RW, Fréchet JMJ, Svec F (2002) Adv Biochem Eng Biotechnol 76:87–125

21.

Santora BP, Gagné MR, Moloy KG, Radu NS (2001) Macromolecules 34(3):658–661CrossRef

22.

Viklund C, Fréchet JMJ, Irgum K (1996) Chem Mater 8(3):744–750CrossRef

23.

Horak D, Dvorak P, Hampla A, Slouf M (2003) J Appl Polym Sci 87(3):425–432CrossRef

24.

Xie S, Svec F, Frechet JMJ (1999) Biotechnol Bioeng 62(1):30–35CrossRef

Title: Synthesis and characterisation of porous polymer microneedles
Authors: Laith Humrez
Maximiano Ramos
Ahmed Al-Jumaily
Mira Petchu
John Ingram
Publication date: 01-09-2011
Publisher: Springer Netherlands
Published in: Journal of Polymer Research / Issue 5/2011
Print ISSN: 1022-9760
Electronic ISSN: 1572-8935
DOI: https://doi.org/10.1007/s10965-010-9505-2

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