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Journal of Nanoparticle Research

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01-12-2017 | Research Paper

Synthesis and characterization of mesoporous and hollow-mesoporous M_xFe_3-xO₄ (M=Mg, Mn, Fe, Co, Ni, Cu, Zn) microspheres for microwave-triggered controllable drug delivery

Authors: Ping Chen, Bin Cui, Yumei Bu, Zhenfeng Yang, Yaoyu Wang

Published in: Journal of Nanoparticle Research | Issue 12/2017

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Abstract

Spinel ferrites can be used in magnetic targeting and microwave heating and can therefore be used for targeted and controllable drug delivery. We used the cetyltrimethylammonium bromide-assisted solvothermal method to synthesize a series of spinel ferrites (M_xFe_3-xO₄, M=Mg, Mn, Fe, Co, Ni, Cu, Zn) with a mesoporous or hollow-mesoporous structure suitable for direct drug loading and the particle diameters ranging from 200 to 350 nm. We investigated the effects of M²⁺ cation on the morphology and properties of these products by analyzing their transmission electron microscopy images, mesoporous properties, magnetic properties, and microwave responses. We chose hollow-mesoporous M_xFe_3-xO₄ (M=Fe, Co, Zn) nanoparticles, which had better overall properties, for the drug VP16 (etoposide) loading and microwave-controlled release. The Co_xFe_3-xO₄ and Fe₃O₄ particles trapped 61.5 and 64.8%, respectively, of the VP16, which were higher than that (60.4%) of Zn_xFe_3-xO₄. Controllable drug release by these simple magnetic nanocarriers can be achieved by microwave irradiation, and VP16-loaded Co_xFe_3-xO₄ released the most VP16 molecules (more than 50% after 1 h and 69.1% after 6 h) under microwave irradiation. Our results confirm the favorable drug loading and microwave-controlled delivery by these ferrites, and lay a theoretical foundation to promote clinical application of the targeted controllable drug delivery system.

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Title: Synthesis and characterization of mesoporous and hollow-mesoporous MxFe3-xO4 (M=Mg, Mn, Fe, Co, Ni, Cu, Zn) microspheres for microwave-triggered controllable drug delivery
Authors: Ping Chen
Bin Cui
Yumei Bu
Zhenfeng Yang
Yaoyu Wang
Publication date: 01-12-2017
Publisher: Springer Netherlands
Published in: Journal of Nanoparticle Research / Issue 12/2017
Print ISSN: 1388-0764
Electronic ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-017-4096-z

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