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03-04-2020 | Materials for life sciences

Synthesis of polyorganophosphazenes and preparation of their polymersomes for reductive/acidic dual-responsive anticancer drugs release

Authors: Rizwan Ullah Khan, Haojie Yu, Li Wang, Qian Zhang, Wei Xiong, Zain-ul-Abdin, Ahsan Nazir, Shah Fahad, Xiang Chen, Tarig Elsharaarani

Published in: Journal of Materials Science | Issue 19/2020

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Abstract

Cancer cells have reductive and acidic environments as compared to the normal body cells. Development of reductive/acidic responsive polymersomes will play a major role in cancer therapy to trigger the release of the loaded drug. In our work, we synthesized three different reductive/acidic dual-responsive polymers, poly[(mPEG-SS-amino) (N,N-diisopropylethylenediamino)phosphazenes] (PPDPs) in different mole ratios of side groups. These PPDPs were characterized by ¹H NMR, ³¹P NMR, FT-IR and GPC. After that, the PPDPs were allowed to self-assemble into drug-loaded polymersomes with high loading content and encapsulation efficiency of hydrophilic/hydrophobic anticancer drugs. The hydrophilic anticancer drug doxorubicin hydrochloride (DOX·HCl) and hydrophobic drug doxorubicin were used. These PPDPs-based polymersomes showed reductive/acidic stimuli-responsive release of anticancer drugs. Moreover, these polymersomes also exhibited suitable hydrodynamic diameters, which will facilitate the longtime circulation in bloodstream due to avoiding renal clearance and close contact to the tumor cells in vascular sections due to enhanced permeability and retention effect. Collectively, these developed polymersomes may provide an effective platform for anticancer drugs delivery.

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Kulkarni P, Haldar MK, You S, Choi Y, Mallik S (2016) Hypoxia-responsive polymersomes for drug delivery to hypoxic pancreatic cancer cells. Biomacromolecules 17:2507–2513. https://doi.org/10.1021/acs.biomac.6b00350CrossRef

Thambi T, Deepagan VG, Yoon HY et al (2014) Hypoxia-responsive polymeric nanoparticles for tumor-targeted drug delivery. Biomaterials 35:1735–1743. https://doi.org/10.1016/j.biomaterials.2013.11.022CrossRef

Jia X, Zhao X, Tian K et al (2016) Novel fluorescent pH/reduction dual stimuli-responsive polymeric nanoparticles for intracellular triggered anticancer drug release. Chem Eng J 295:468–476. https://doi.org/10.1016/j.cej.2016.03.065CrossRef

Shen Y, Jin E, Zhang B et al (2010) Prodrugs forming high drug loading multifunctional nanocapsules for intracellular cancer drug delivery. J Am Chem Soc 132:4259–4265. https://doi.org/10.1021/ja909475mCrossRef

Zhou J, Tang Q, Zhong J et al (2018) Construction of glucose and H₂O₂ dual stimuli-responsive polymeric vesicles and their application in controlled drug delivery. J Mater Sci 53:14063–14074. https://doi.org/10.1007/s10853-018-2622-8CrossRef

Wang M, Wang T, Wang D, Jiang W, Fu J (2019) Acid and light stimuli-responsive mesoporous silica nanoparticles for controlled release. J Mater Sci 54:6199–6211. https://doi.org/10.1007/s10853-019-03325-xCrossRef

Conner SD, Schmid SL (2003) Regulated portals of entry into the cell. Nature 422:37–44. https://doi.org/10.1038/nature01451CrossRef

Hebert ML, Shah DS, Blake P, Turner JP, Servoss SL (2013) Tunable peptoid microspheres: effects of side chain chemistry and sequence. Org Biomol Chem 11:4459–4464. https://doi.org/10.1039/C3OB40561CCrossRef

Chen H, Kuang Y, Liu R et al (2018) Dual-pH-sensitive mesoporous silica nanoparticle-based drug delivery system for tumor-triggered intracellular drug release. J Mater Sci 53:10653–10665. https://doi.org/10.1007/s10853-018-2363-8CrossRef

10.

Rapoport N (2007) Physical stimuli-responsive polymeric micelles for anti-cancer drug delivery. Prog Polyme Sci 32:962–990. https://doi.org/10.1016/j.progpolymsci.2007.05.009CrossRef

11.

Vlassi E, Papagiannopoulos A, Pispas S (2017) Amphiphilic poly(2-oxazoline) copolymers as self-assembled carriers for drug delivery applications. Eur Poly J 88:516–523. https://doi.org/10.1016/j.eurpolymj.2016.10.034CrossRef

12.

Du J, Reilly RK (2009) Advances and challenges in smart and functional polymer vesicles. Soft Matter 5:3544–3561. https://doi.org/10.1039/B905635ACrossRef

13.

Onaca O, Enea R, Hughes DW, Meier W (2009) Stimuli-responsive polymersomes as nanocarriers for drug and gene delivery. Macromol Biosci 9:129–139. https://doi.org/10.1002/mabi.200800248CrossRef

14.

Meng F, Zhong Z, Feijen J (2009) Stimuli-responsive polymersomes for programmed drug delivery. Biomacromolecules 10:197–209. https://doi.org/10.1021/bm801127dCrossRef

15.

Li MH, Keller P (2009) Stimuli-responsive polymer vesicles. Soft Matter 5:927–937. https://doi.org/10.1039/b815725aCrossRef

16.

He L, Xue L, Xu J et al (2009) Compound vesicle fusion increases quantal size and potentiates synaptic transmission. Nature 459:93–97. https://doi.org/10.1038/nature07860CrossRef

17.

Zhang JX, Qiu LY, Jin Y, Zhu KJ (2006) Multimorphological self-assemblies of amphiphilic graft polyphosphazenes with oligopoly(N-isopropylacrylamide) and ethyl 4-aminobenzoate as side groups. Macromolecules 39:451–455. https://doi.org/10.1021/ma052152qCrossRef

18.

Mushtaq MW, Kanwal F, Batool A et al (2017) Polymer-coated CoFe₂O₄ nanoassemblies as biocompatible magnetic nanocarriers for anticancer drug delivery. J Mater Sci 52:9282–9293. https://doi.org/10.1007/s10853-017-1141-3CrossRef

19.

Pawar PV, Gohil SV, Jain JP, Kumar N (2013) Functionalized polymersomes for biomedical applications. Polym Chem 4:3160–3176. https://doi.org/10.1039/C3PY00023KCrossRef

20.

Discher BM, Won YY, Ege DS et al (1999) Polymersomes: tough vesicles made from diblock copolymers. Science 284:1143–1146. https://doi.org/10.1126/science.284.5417.1143CrossRef

21.

Leriche G, Cifelli JL, Sibucao KC et al (2017) Characterization of drug encapsulation and retention in archaea-inspired tetraether liposomes. Org Biomol Chem 15:2157–2162. https://doi.org/10.1039/C6OB02832BCrossRef

22.

Kita-Tokarczyk K, Grumelard J, Haefele T, Meier W (2005) Block copolymer vesicles-using concepts from polymer chemistry to mimic biomembranes. Polymer 46:3540–3563. https://doi.org/10.1016/j.polymer.2005.02.083CrossRef

23.

You X-R, Ju X-J, He F et al (2017) Polymersomes with rapid K⁺-triggered drug-release behaviors. ACS App Mater Interface 9:19258–19268. https://doi.org/10.1021/acsami.7b05701CrossRef

24.

Battaglia G, Ryan AJ (2005) Bilayers and interdigitation in block copolymer vesicles. J Am Chem Soc 127:8757–8764. https://doi.org/10.1021/ja050742yCrossRef

25.

Balasubramanian V, Herranz Blanco B, Almeida PV, Hirvonen J, Santos HA (2016) Multifaceted polymersome platforms: spanning from self-assembly to drug delivery and protocells. Prog Polym Sci 60:51–85. https://doi.org/10.1016/j.progpolymsci.2016.04.004CrossRef

26.

Messager L, Gaitzsch J, Chierico L, Battaglia G (2014) Novel aspects of encapsulation and delivery using polymersomes. Curr Opin Pharmacol 18:120–128. https://doi.org/10.1016/j.coph.2014.09.017CrossRef

27.

Qiao ZY, Ji R, Huang XN et al (2013) Polymersomes from dual responsive block copolymers: drug encapsulation by heating and acid-triggered release. Biomacromolecules 14:1555–1563. https://doi.org/10.1021/bm400180nCrossRef

28.

Liu P, Zhang R, Pei M (2017) Design of pH/reduction dual-responsive nanoparticles as drug delivery system for DOX: modulating controlled release behavior with bimodal drug-loading. Colloid Surface B 160:455–461. https://doi.org/10.1016/j.colsurfb.2017.09.049CrossRef

29.

Callari M, Wong S, Lu H, Aldrich Wright J, De Souza P, Stenzel MH (2017) Drug induced self-assembly of triblock copolymers into polymersomes for the synergistic dual-drug delivery of platinum drugs and paclitaxel. Polym Chem 8:6289–6299. https://doi.org/10.1039/C7PY01162HCrossRef

30.

Wu L, Leng D, Cun D, Foged C, Yang M (2017) Advances in combination therapy of lung cancer: rationales, delivery technologies and dosage regimens. J Control Release 260:78–91. https://doi.org/10.1016/j.jconrel.2017.05.023CrossRef

31.

Kelly GJ, Kia AF-A, Hassan F et al (2016) Polymeric prodrug combination to exploit the therapeutic potential of antimicrobial peptides against cancer cells. Org Biomol Chem 14:9278–9286. https://doi.org/10.1039/C6OB01815GCrossRef

32.

Sheng Y, You Y, Chen Y (2016) Dual-targeting hybrid peptide-conjugated doxorubicin for drug resistance reversal in breast cancer. Int J Pharma 512:1–13. https://doi.org/10.1016/j.ijpharm.2016.08.016CrossRef

33.

Miao J, Du YZ, Yuan H, Zhang XG, Hu FQ (2013) Drug resistance reversal activity of anticancer drug loaded solid lipid nanoparticles in multi-drug resistant cancer cells. Colloid Surface B 110:74–80. https://doi.org/10.1016/j.colsurfb.2013.03.037CrossRef

34.

Lavrador P, Gaspar VM, Mano JF (2018) Stimuli-responsive nanocarriers for delivery of bone therapeutics—barriers and progresses. J Control Release 273:51–67. https://doi.org/10.1016/j.jconrel.2018.01.021CrossRef

35.

Zhang Y, He P, Liu X et al (2018) Synthesis of PEGylated alternating copolymer bearing thioether pendants for oxidation responsive drug delivery. Eur Polym J 107:308–314. https://doi.org/10.1016/j.eurpolymj.2018.09.004CrossRef

36.

Guo S, Liang T, Song Y et al (2017) Supramolecular polymersomes constructed from water-soluble pillar[5]arene and cationic poly(glutamamide)s and their applications in targeted anticancer drug delivery. Polym Chem 8:5718–5725. https://doi.org/10.1039/C7PY01259DCrossRef

37.

Huang J, Wu F, Yu Y, Huang H, Zhang S, You J (2017) Lipoic acid based core cross-linked micelles for multivalent platforms: design, synthesis and application in bio-imaging and drug delivery. Org Biomol Chem 15:4798–4802. https://doi.org/10.1039/C7OB00927ECrossRef

38.

Nakayama M, Okano T, Miyazaki T, Kohori F, Sakai K, Yokoyama M (2006) Molecular design of biodegradable polymeric micelles for temperature-responsive drug release. J Control Release 115:46–56. https://doi.org/10.1016/j.jconrel.2006.07.007CrossRef

39.

Li Y, Lokitz BS, Cormick CLM (2006) Thermally responsive vesicles and their structural “locking” through polyelectrolyte complex formation. Angew Chem Int Ed 45:5792–5795. https://doi.org/10.1002/anie.200602168CrossRef

40.

Du J, Armes SP (2005) pH-responsive vesicles based on a hydrolytically self-cross-linkable copolymer. J Am Chem Soc 27:447–451. https://doi.org/10.1021/ja054755nCrossRef

41.

Wang L, Liu G, Wang X, Hu J, Zhang G, Liu S (2015) Acid-disintegratable polymersomes of pH-responsive amphiphilic diblock copolymers for intracellular drug delivery. Macromolecules 48:7262–7272. https://doi.org/10.1021/acs.macromol.5b01709CrossRef

42.

Robertson JD, Yealland G, Avila-Olias M et al (2014) pH-sensitive tubular polymersomes: formation and applications in cellular delivery. ACS Nano 8:4650–4661. https://doi.org/10.1021/nn5004088CrossRef

43.

Wang C, Guo Y, Wang Y, Xu H, Zhang X (2009) Redox responsive supramolecular amphiphiles based on reversible charge transfer interactions. Chem Commun 36:5380–5382. https://doi.org/10.1039/B912502GCrossRef

44.

Li Y, Tong R, Xia H, Zhang H, Xuan J (2010) High intensity focused ultrasound and redox dual responsive polymer micelles. Chem Commun 46:7739–7741. https://doi.org/10.1039/c0cc02628jCrossRef

45.

Ercole F, Davis TP, Evans RA (2010) Photo-responsive systems and biomaterials: photochromic polymers, light-triggered self-assembly, surface modification, fluorescence modulation and beyond. Polym Chem 1:37–54. https://doi.org/10.1039/B9PY00300BCrossRef

46.

Huang L, Yu C, Huang T, Xu S, Bai Y, Zhou Y (2016) Ultrasound-responsive ultrathin multiblock copolyamide vesicles. Nanoscale 8:4922–4926. https://doi.org/10.1039/c5nr08596aCrossRef

47.

Li J, Wang Y, Zhu Y, Oupický D (2013) Recent advances in delivery of drug-nucleic acid combinations for cancer treatment. J Control Release 172:589–600. https://doi.org/10.1016/j.jconrel.2013.04.010CrossRef

48.

Petrov PD, Yoncheva K, Gancheva V, Konstantinov S, Trzebicka B (2016) Multifunctional block copolymer nanocarriers for co-delivery of silver nanoparticles and curcumin: synthesis and enhanced efficacy against tumor cells. Eur Polym J 81:24–33. https://doi.org/10.1016/j.eurpolymj.2016.05.010CrossRef

49.

Foster T, Dorfman KD, Ted Davis H (2010) Giant biocompatible and biodegradable PEG-PMCL vesicles and microcapsules by solvent evaporation from double emulsion droplets. J Colloid Interface Sci 351:140–150. https://doi.org/10.1016/j.jcis.2010.05.020CrossRef

50.

Ang CY, Tan SY, Zhao Y (2014) Recent advances in biocompatible nanocarriers for delivery of chemotherapeutic cargoes towards cancer therapy. Org Biomol Chem 12:4776–4806. https://doi.org/10.1039/C4OB00164HCrossRef

51.

Hu X, Zhang Y, Xie Z, Jing X, Bellotti A, Gu Z (2017) Stimuli-responsive polymersomes for biomedical applications. Biomacromolecules 18:649–673. https://doi.org/10.1021/acs.biomac.6b01704CrossRef

52.

Rizwan Ullah K, Li W, Haojie Y et al (2018) Poly(organo)phosphazenes: recent progress in the synthesis and applications in tissue engineering and drug delivery. Russ Chem Rev 87:109. https://doi.org/10.1070/RCR4757CrossRef

53.

Schulze K, Ebensen T, Babiuk LA, Gerdts V, Guzman CA (2017) Intranasal vaccination with an adjuvanted polyphosphazenes nanoparticle-based vaccine formulation stimulates protective immune responses in mice. Nanomed Nanotechnol Biomed 13:2169–2178. https://doi.org/10.1016/j.nano.2017.05.012CrossRef

54.

Martinez AP, Qamar B, Fuerst TR, Muro S, Andrianov AK (2017) Biodegradable “smart” polyphosphazenes with intrinsic multifunctionality as intracellular protein delivery vehicles. Biomacromolecules 18:2000–2011. https://doi.org/10.1021/acs.biomac.7b00537CrossRef

55.

Akram M, Wang L, Yu H et al (2016) Synthesis of reductive responsive polyphosphazenes and their fabrication of nanocarriers for drug delivery application. Int J Polym Mater Polym Biomater 65:581–591. https://doi.org/10.1080/00914037.2016.1149847CrossRef

56.

Xu J, Zhu X, Qiu L (2016) Polyphosphazene vesicles for co-delivery of doxorubicin and chloroquine with enhanced anticancer efficacy by drug resistance reversal. Int J Pharma 498:70–81. https://doi.org/10.1016/j.ijpharm.2015.12.003CrossRef

57.

Fu J, Liang L, Qiu L (2017) In situ generated gold nanoparticle hybrid polymersomes for water-soluble chemotherapeutics: inhibited leakage and pH-responsive intracellular release. Adv Funct Mater 27:1604981. https://doi.org/10.1002/adfm.201604981CrossRef

58.

Peng Y, Zhu X, Qiu L (2016) Electroneutral composite polymersomes self-assembled by amphiphilic polyphosphazenes for effective miR-200c in vivo delivery to inhibit drug resistant lung cancer. Biomaterials 87:1–17. https://doi.org/10.1016/j.biomaterials.2016.08.001CrossRef

59.

Zheng C, Xu J, Yao X, Xu J, Qiu L (2011) Polyphosphazene nanoparticles for cytoplasmic release of doxorubicin with improved cytotoxicity against Dox-resistant tumor cells. J Colloid Interface Sci 355:374–382. https://doi.org/10.1016/j.jcis.2010.12.004CrossRef

60.

Dong X, Yang B, Jia HZ et al (2016) Acidity-induced destabilization of nano-sized supramolecular linear-hyperbranched polymersome for controlled release of encapsulated cargoes. Macromol Biosci 16:175–181. https://doi.org/10.1002/mabi.201500298CrossRef

61.

Gao M, Peng Y, Jiang L, Qiu L (2018) Effective intracellular delivery and Th1 immune response induced by ovalbumin loaded in pH-responsive polyphosphazene polymersomes. Nanomed nanotechnol Biol Med 14:1609–1618. https://doi.org/10.1016/j.nano.2018.04.001CrossRef

62.

Zheng C, Yao X, Qiu L (2011) Novel polymeric vesicles with pH-induced deformation character for advanced drug delivery. Macromol Biosci 11:338–343. https://doi.org/10.1002/mabi.201000333CrossRef

63.

Liang L, Fu J, Qiu L (2018) Design of pH-sensitive nanovesicles via cholesterol analogue incorporation for improving in vivo delivery of chemotherapeutics. ACS App Mater Interface 10:5213–5226. https://doi.org/10.1021/acsami.7b16891CrossRef

64.

Li X, Zhu X, Qiu L (2016) Constructing aptamer anchored nanovesicles for enhanced tumor penetration and cellular uptake of water soluble chemotherapeutics. Acta Biomater 35:269–279. https://doi.org/10.1016/j.actbio.2016.02.012CrossRef

65.

Khan RU, Wang L, Yu H et al (2019) Synthesis of polyorganophosphazenes and fabrication of their blend microspheres and micro/nanofibers as drug delivery systems. Int J Polym Mater Polym Biomater 2019:1–22. https://doi.org/10.1080/00914037.2019.1581203CrossRef

66.

Qiu LY, Yan MQ (2009) Constructing doxorubicin-loaded polymeric micelles through amphiphilic graft polyphosphazenes containing ethyl tryptophan and PEG segments. Acta Biomater 5:2132–2141. https://doi.org/10.1016/j.actbio.2009.02.005CrossRef

67.

Zhang JX, Qiu LY, Jin Y, Zhu KJ (2005) Physicochemical characterization of polymeric micelles constructed from novel amphiphilic polyphosphazene with poly(N-isopropylacrylamide) and ethyl 4-aminobenzoate as side groups. Colloid Surface B 3:123–130. https://doi.org/10.1016/j.colsurfb.2005.03.012CrossRef

68.

Xu J, Zhao Q, Jin Y, Qiu L (2014) High loading of hydrophilic/hydrophobic doxorubicin into polyphosphazene polymersome for breast cancer therapy. Nanomed Nanotechnol Biomed 10:349–358. https://doi.org/10.1016/j.nano.2013.08.004CrossRef

69.

Yen HC, Cabral H, Mi P et al (2014) Light-induced cytosolic activation of reduction-sensitive camptothecin-loaded polymeric micelles for spatiotemporally controlled in vivo chemotherapy. ACS Nano 8:11591–11602. https://doi.org/10.1021/nn504836sCrossRef

70.

Sohn YS, Cho YH, Baek H, Jung OS (1995) Synthesis and properties of low molecular weight polyphosphazenes. Macromolecules 28:7566–7568. https://doi.org/10.1021/ma00126a039CrossRef

71.

Allcock HR, Kugel RL (1965) Synthesis of high polymeric alkoxy- and aryloxyphosphonitriles. J Am Chem Soc 87:4216–4217. https://doi.org/10.1021/ja01096a056CrossRef

72.

Chen C, Qian YC, Sun CB, Huang XJ (2015) Self-assembly and morphological transitions of random amphiphilic poly(beta-d-glucose-co-1-octyl) phosphazenes. Soft Matter 11:6266–6274. https://doi.org/10.1039/c5sm01354bCrossRef

73.

Choi HS, Liu W, Misra P et al (2007) Renal clearance of quantum dots. Nat Biotechnol 25:1165. https://doi.org/10.1038/nbt1340CrossRef

74.

Hrkach J, Von Hoff D, Mukkaram Ali M et al (2012) Preclinical development and clinical translation of a PSMA-targeted docetaxel nanoparticle with a differentiated pharmacological profile. Sci Transl Med 4:128ra39. https://doi.org/10.1126/scitranslmed.3003651CrossRef

75.

Lv S, Tang Z, Li M et al (2014) Co-delivery of doxorubicin and paclitaxel by PEG-polypeptide nanovehicle for the treatment of non-small cell lung cancer. Biomaterials 35:6118–6129. https://doi.org/10.1016/j.biomaterials.2014.04.034CrossRef

76.

Zheng C, Qiu L, Zhu K (2009) Novel polymersomes based on amphiphilic graft polyphosphazenes and their encapsulation of water-soluble anti-cancer drug. Polymer 50:1173–1177. https://doi.org/10.1016/j.polymer.2009.01.004CrossRef

77.

Cleland WW (1964) Dithiothreitol, a new protective reagent for SH groups. Biochemistry 3:480–482. https://doi.org/10.1021/bi00892a002CrossRef

78.

Khorsand Sourkohi B, Cunningham A, Zhang Q, Oh JK (2011) Biodegradable block copolymer micelles with thiol-responsive sheddable coronas. Biomacromolecules 12:3819–3825. https://doi.org/10.1021/bm2011032CrossRef

79.

Attia AB, Yang C, Tan JP et al (2013) The effect of kinetic stability on biodistribution and anti-tumor efficacy of drug-loaded biodegradable polymeric micelles. Biomaterials 34:3132–3140. https://doi.org/10.1016/j.biomaterials.2013.01.042CrossRef

Title: Synthesis of polyorganophosphazenes and preparation of their polymersomes for reductive/acidic dual-responsive anticancer drugs release
Authors: Rizwan Ullah Khan
Haojie Yu
Li Wang
Qian Zhang
Wei Xiong
Zain-ul-Abdin
Ahsan Nazir
Shah Fahad
Xiang Chen
Tarig Elsharaarani
Publication date: 03-04-2020
Publisher: Springer US
Published in: Journal of Materials Science / Issue 19/2020
Print ISSN: 0022-2461
Electronic ISSN: 1573-4803
DOI: https://doi.org/10.1007/s10853-020-04595-6

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