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2018 | OriginalPaper | Chapter

12. Targeting Protein-Protein Interactions in Small GTPases

Authors : Jiahui Liu, Ning Kang, Yaxue Zhao, Mingyan Zhu

Published in: Targeting Protein-Protein Interactions by Small Molecules

Publisher: Springer Singapore

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Abstract

Small GTPase is GDP-/GTP-binding proteins that serve as molecular switches to control a variety of essential processes inside cells. Misfunction of small GTPase is frequently discovered in diseases such as cancer, neurodegenerative disease, and other diseases. Controlling the activity of normal and mutated small GTPase are of great meaning in drug discovery. As small GTPases recruit large network of PPIs for signal transduction, rich PPIs are contained in small GTPase signaling pathways, such as small GTPase-GEF, small GTPase-effector interactions, and other PPIs. Targeting PPIs in small GTPase will serve as an effective way to modulate small GTPase activities and signal transduction. In this chapter, we will discuss a variety of approaches and novel strategies to target PPIs in small GTPases and recent advances with selected examples from last five years.

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Title: Targeting Protein-Protein Interactions in Small GTPases
Authors: Jiahui Liu
Ning Kang
Yaxue Zhao
Mingyan Zhu
Publisher: Springer Singapore
Book: Targeting Protein-Protein Interactions by Small Molecules
Print ISBN: 978-981-13-0772-0

Electronic ISBN: 978-981-13-0773-7

Copyright Year: 2018
DOI: https://doi.org/10.1007/978-981-13-0773-7_12