The Study of Biotransformation Products and Microbiological Activity of Antibacterial Drugs In Vivo

Many pharmaceutical drugs and their metabolites are either partially or not removed by conventional wastewater treatment technologies, resulting in their accumulation in soils and agricultural products. The treatment of mice by metronidazole, ciprofloxacin, and iodine adduct caused positive dynamics in the development of septicopyemia; however, it led to the formation of resistant S. aureus to metronidazole. It was shown that the ciprofloxacin, metronidazole, and iodine adduct biotransformation products are found in the urine and feces of rats with their course application during 7 days. The highest concentrations of ciprofloxacin and metronidazole were found in the urine and feces—iodides. Several studies required to include biotransformed pharmaceutical drugs (metabolites) in open water sources program monitoring of Kazakhstan.