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2013 | OriginalPaper | Chapter

The Use of Nanostructures for DNA Transfection

Authors : Vinicius Farias Campos, Virgínia Yurgel, Fabiana Kömmling Seixas, Tiago Collares

Published in: NanoCarbon 2011

Publisher: Springer Berlin Heidelberg

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Abstract

The interaction between nanostructured materials and living systems is of fundamental and practical interest and will determine the biocompatibility, potential utilities and applications of novel nanomaterials in biological settings. The pursuit of new types of molecular transporters is an active area of research, due to the high impermeability of cell membranes and other biological barriers to foreign substances and the need for intercellular delivery of molecules via cell-penetrating transporter for drug, gene or protein therapeutics. Here, is described the novel nanostructure-based transfection systems. The transfection uses of nanopolymers, nanoparticles and nanotubes are the main focus of this review. In addition are described the technique called NanoSMGT that uses nanostructures for DNA transfection in sperm cells that could be used for transgenic animal generation or human gene therapy.

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Title: The Use of Nanostructures for DNA Transfection
Authors: Vinicius Farias Campos
Virgínia Yurgel
Fabiana Kömmling Seixas
Tiago Collares
Publisher: Springer Berlin Heidelberg
Book: NanoCarbon 2011
Print ISBN: 978-3-642-31959-4

Electronic ISBN: 978-3-642-31960-0

Copyright Year: 2013
DOI: https://doi.org/10.1007/978-3-642-31960-0_4

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