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Published in:
2005 | OriginalPaper | Chapter
Towards a Dynamic Neuropharmacology: Integrating Network and Receptor Levels
Authors : Péter Érdi, János Tóth
Published in: Brain, Vision, and Artificial Intelligence
Publisher: Springer Berlin Heidelberg
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Computational modeling by integrating compartmental neural technique and detailed kinetic description of pharmacological modulation of transmitter – receptor interaction is offered as a method to test the electrophysiological and behavioral effects of putative drugs. Even more, an inverse method is suggested as a method for controlling a neural system to realize a prescribed temporal pattern. Generation and pharamcological modulation of theta rhytm related to anxiety is analyzed. Integrative modeling might help to find positive allosteric modulators of GABA
A
α
1
subunits as potential candidates for being selective anxyolitics.