Translocation paradox of a linear polymer chain in a semi-entangled semi-free space

In this paper, we introduce a special device, in which the topological rejection effect in the study of biomacromolecule translocation competes with the entropic tensile force. The expected results for the translocation of the polymer chain given by these two different theories do not coincide with each other, so we call this problem the “translocation paradox”. The dynamics of the polymer chain and the preference translocation in such device are studied using computer simulation method. Surprisingly, these results do not completely satisfy all these hypothesis. We provide a plausible explanation which coincides our simulation results perfectly. Meanwhile, this explanation provides a possible solution to the design of translocation device in biophysics field.