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Published in:
Aligned Nanowire Growth Read chapter Read first chapter

2018 | OriginalPaper | Chapter

16. 3D Printing of Pharmaceuticals

Authors : Muzna Sadia, Mohamed Albed Alhnan, Waqar Ahmed, Mark J. Jackson

Published in: Micro and Nanomanufacturing Volume II

Publisher: Springer International Publishing

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Abstract

In the new era of medicine, 3D printing technique in pharmaceutical manufacturing has already yielded success. For example, Aprecia®, an FDA-approved pharmaceutical company, has launched its first approved product which is not only unique because of a novel manufacturing process but also better than conventional compressed tablets. 3D printing is an inexpensive additive manufacturing technique that builds a 3D object by successive layering on top of each other in a 2D fashion. The layering of the object in process is controlled digitally in a computer-aided design (CAD). 3D printing of pharmaceuticals suits best for personalised therapy, not only in case of doses but dosage form as well. A personalised dosage form can be designed and printed in such a way that the drugs are combined in a single pill (polypill). This cannot only make the therapy and schedule convenient for patient but also increase adherence.

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Literature
1.
Melchels FPW, Feijen J, Grijpma DW (2010) A review on stereolithography and its applications in biomedical engineering. Biomaterials 31(24):6121–6130CrossRef
2.
Khaled SA et al (2015) 3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles. J Control Release 217:308–314CrossRef
3.
Garber AJ et al (2003) Efficacy of glyburide/metformin tablets compared with initial monotherapy in type 2 diabetes. J Clin Endocrinol Metab 88(8):3598–3604CrossRef
4.
Murphy SV, Atala A (2014) 3D bioprinting of tissues and organs. Nat Biotechnol 32(8):773–785CrossRef
5.
CSC Leading Edge Forum (2012) 3D printing and the future of manufacturing. FALL. 36.
6.
Deckard CR (1989) Method and apparatus for producing parts by selective sintering. Google Patents.
7.
Crump SS (1992) Apparatus and method for creating three-dimensional objects. Google Patents.
8.
Hull CW et al. (1994) Method and apparatus for production of high resolution three-dimensional objects by stereolithography. Google Patents.
9.
Verma A, Rai R (2013) Energy efficient modeling and optimization of additive manufacturing processes. In solid freeform fabrication symposium, Austin, TX.
10.
Leong KF et al (2001) Fabrication of porous polymeric matrix drug delivery devices using the selective laser sintering technique. Proc Inst Mech Eng H 215(2):191–201CrossRef
11.
Jacob J (2014) et al. Rapid disperse dosage form containing levetiracetam. Google Patents.
12.
Katstra WE et al (2000) Oral dosage forms fabricated by three dimensional printing. J Control Release 66(1):1–9CrossRef
13.
Rowe CW et al (2000) Multimechanism oral dosage forms fabricated by three dimensional printing. J Control Release 66(1):11–17CrossRef
14.
Chia HN, Wu BM (2015) Recent advances in 3D printing of biomaterials. J Biol Eng 9:4CrossRef
15.
Khaled SA et al (2014) Desktop 3D printing of controlled release pharmaceutical bilayer tablets. Int J Pharm 461(1–2):105–111CrossRef
16.
Skowyra J, Pietrzak K, Alhnan MA (2015) Fabrication of extended-release patient-tailored prednisolone tablets via fused deposition modelling (FDM) 3D printing. Eur J Pharm Sci 68:11–17CrossRef
17.
Pietrzak K, Isreb A, Alhnan MA (2015) A flexible-dose dispenser for immediate and extended release 3D printed tablets. Eur J Pharm Biopharm 96:380–387CrossRef
18.
Melocchi A et al (2015) 3D printing by fused deposition modeling (FDM) of a swellable/erodible capsular device for oral pulsatile release of drugs. J Drug Deliv Sci Technol 30(Part B):360–367CrossRef
19.
Wang J et al (2016) Stereolithographic (SLA) 3D printing of oral modified-release dosage forms. Int J Pharm 503(1–2):207–212CrossRef
20.
Wang C-C et al (2006) Development of near zero-order release dosage forms using three-dimensional printing (3-DP™) technology. Drug Dev Ind Pharm 32(3):367–376CrossRef
21.
Huang W et al (2007) Levofloxacin implants with predefined microstructure fabricated by three-dimensional printing technique. Int J Pharm 339(1–2):33–38CrossRef
22.
Yu DG et al (2009) Novel drug delivery devices for providing linear release profiles fabricated by 3DP. Int J Pharm 370(1–2):160–166CrossRef
23.
Yu DG et al (2009) Novel oral fast-disintegrating drug delivery devices with predefined inner structure fabricated by three-dimensional printing. J Pharm Pharmacol 61(3):323–329CrossRef
24.
Wu BM et al (1996) Solid free-form fabrication of drug delivery devices. J Control Release 40(1–2):77–87CrossRef
25.
Khaled SA et al (2015) 3D printing of tablets containing multiple drugs with defined release profiles. Int J Pharm 494(2):643–650CrossRef
26.
Goyanes A et al (2015) 3D printing of medicines: engineering novel oral devices with unique design and drug release characteristics. Mol Pharm 12(11):4077–4084CrossRef
27.
Goyanes A et al (2015) Fabrication of controlled-release budesonide tablets via desktop (FDM) 3D printing. Int J Pharm 496(2):414–420CrossRef
28.
Goyanes A et al (2014) Fused-filament 3D printing (3DP) for fabrication of tablets. Int J Pharm 476(1–2):88–92CrossRef
29.
Goyanes A et al (2015) 3D printing of modified-release aminosalicylate (4-ASA and 5-ASA) tablets. Eur J Pharm Biopharm 89:157–162CrossRef
30.
Goyanes A et al (2015) Effect of geometry on drug release from 3D printed tablets. Int J Pharm 494(2):657–663CrossRef
31.
Water JJ et al (2015) Three-dimensional printing of drug-eluting implants: preparation of an antimicrobial polylactide feedstock material. J Pharm Sci 104(3):1099–1107CrossRef
32.
Weisman JA et al (2015) Antibiotic and chemotherapeutic enhanced three-dimensional printer filaments and constructs for biomedical applications. Int J Nanomedicine 10:357–370
33.
Sun Y, Soh S (2015) Printing tablets with fully customizable release profiles for personalized medicine. Adv Mater 27(47):7847–7853CrossRef
34.
Alhijjaj M, Belton P, Qi S (2016) An investigation into the use of polymer blends to improve the printability of and regulate drug release from pharmaceutical solid dispersions prepared via fused deposition modeling (FDM) 3D printing. Eur J Pharm Biopharm 108:111–125CrossRef
35.
Okwuosa TC et al (2016) A lower temperature FDM 3D printing for the manufacture of patient-specific immediate release tablets. Pharm Res 33(11):2704–2712CrossRef
36.
Okwuosa TC et al (2017) Fabricating a shell-core delayed release tablet using dual FDM 3D printing for patient-Centred therapy. Pharm Res 34(2):427–437CrossRef
37.
Sadia M et al (2016) Adaptation of pharmaceutical excipients to FDM 3D printing for the fabrication of patient-tailored immediate release tablets. Int J Pharm 513(1–2):659–668CrossRef
38.
Zhang J et al (2017) Coupling 3D printing with hot-melt extrusion to produce controlled-release tablets. Int J Pharm 519(1–2):186–197CrossRef
39.
Goyanes A et al (2017) Development of modified release 3D printed tablets (printlets) with pharmaceutical excipients using additive manufacturing. Int J Pharm 527(1–2):21–30CrossRef
Metadata
Title
3D Printing of Pharmaceuticals
Authors
Muzna Sadia
Mohamed Albed Alhnan
Waqar Ahmed
Mark J. Jackson
Copyright Year
2018
Book
Micro and Nanomanufacturing Volume II

Print ISBN: 978-3-319-67130-7

Electronic ISBN: 978-3-319-67132-1

Copyright Year: 2018

DOI
https://doi.org/10.1007/978-3-319-67132-1_16