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Polymer Bulletin

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15-03-2019 | Original Paper

5-Fluorouracil and curcumin co-encapsulated chitosan/reduced graphene oxide nanocomposites against human colon cancer cell lines

Authors: S. Dhanavel, T. A. Revathy, T. Sivaranjani, K. Sivakumar, P. Palani, V. Narayanan, A. Stephen

Published in: Polymer Bulletin | Issue 1/2020

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Abstract

Recent attention on chemotherapy against cancer is to explore the effective therapy through targeted delivery of anticancer agents to the tumor site by manipulating pharmacokinetic properties of nanocarriers. 5-Fluorouracil (5-FU) and curcumin (CUR) loaded chitosan/reduced graphene oxide (CS/rGO) nanocomposite has been prepared via simple chemical method. The polymer matrix-type chitosan/rGO nanocomposite, before and after encapsulation, has been analyzed by various characterizations. Entrapment and loading efficiencies were estimated. The results that demonstrated higher entrapment efficiency (> 90%) were achieved by CS/rGO nanocarrier. Various kinetic models were used to analyze the release model and to elucidate the release mechanism of the drug from CS/rGO nanocomposite. The synergistic cytotoxicity was observed on addition of 5-FU + CUR-loaded CS/rGO nanocomposite which shows the effectiveness of the system toward the inhibition of growth of HT-29 colon cancer cells. The better cytotoxicity with an IC₅₀ of 23.8 μg/mL was observed for dual-drug-loaded nanocomposite.

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Title: 5-Fluorouracil and curcumin co-encapsulated chitosan/reduced graphene oxide nanocomposites against human colon cancer cell lines
Authors: S. Dhanavel
T. A. Revathy
T. Sivaranjani
K. Sivakumar
P. Palani
V. Narayanan
A. Stephen
Publication date: 15-03-2019
Publisher: Springer Berlin Heidelberg
Published in: Polymer Bulletin / Issue 1/2020
Print ISSN: 0170-0839
Electronic ISSN: 1436-2449
DOI: https://doi.org/10.1007/s00289-019-02734-x

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