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Journal of Sol-Gel Science and Technology
Published in: Journal of Sol-Gel Science and Technology 3/2023

05-09-2023 | Original Paper: Sol-gel and hybrid materials for biological and health (medical) applications

A drug delivery system with fluorescent labeling for the delivery and release of the carboxylate-type camptothecin and its cytotoxicity on HepG2 cancer cell

Authors: Yijun Liu, Tingting Li, Xingxing Qiu, Xiaoqiang Shang, Yufeng Chen

Published in: Journal of Sol-Gel Science and Technology | Issue 3/2023

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Abstract

To facilitate the loading and targeted delivery of drugs, the camptothecin with negatively charged is used for the intercalation of Eu3+-doped MgAl-LDH with fluorescent property. X-ray diffraction (XRD) results show that the basal spacing (27.3 Å) of the intercalated sample is significantly greater than that of the initial Eu3+-doped MgAl-LDH (8.6 Å), implying the intercalation of the carboxylate-type camptothecin in the interlayer of the Eu3+-doped MgAl-LDH. The in vitro release assay in phosphate buffer solution (PBS) at pH of 7.4 reveals that the camptothecin shows a sustained release and the release is up to 900 min. The cumulative concentration (C) of the releasing camptothecin versus time (t) is fitted by the ExpDec2 Model, and is consistent with the equation: C=A1exp(-t/t1)+A2exp(-t/t2) + C0 (R2 = 0.99886). In addition, the fluorescent signals of the drug delivery system differ significantly during delivery and release of camptothecin, by which the delivery and release of camptothecin may be “recognized”. Cytotoxicity assay confirms that the Eu3+-doped MgAl-LDH loaded with the carboxylate-type camptothecin takes an obvious anticancer effect against HepG2 cancer cell, and the anticancer effect is better than that of the pure lactone-type camptothecin, which is very different from the prevailing view that the carboxylate camptothecin has no anticancer activity.

Graphical Abstract

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Metadata
Title
A drug delivery system with fluorescent labeling for the delivery and release of the carboxylate-type camptothecin and its cytotoxicity on HepG2 cancer cell
Authors
Yijun Liu
Tingting Li
Xingxing Qiu
Xiaoqiang Shang
Yufeng Chen
Publication date
05-09-2023
Publisher
Springer US
Published in
Journal of Sol-Gel Science and Technology / Issue 3/2023
Print ISSN: 0928-0707
Electronic ISSN: 1573-4846
DOI
https://doi.org/10.1007/s10971-023-06218-3

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