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Journal of Materials Science
Published in: Journal of Materials Science 4/2019

19-10-2018 | Materials for life sciences

A molecularly imprinted composite based on graphene oxide for targeted drug delivery to tumor cells

Authors: Shuang Han, Liqiang Su, Minghui Zhai, Lin Ma, Shiwei Liu, Yue Teng

Published in: Journal of Materials Science | Issue 4/2019

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Abstract

Conventional cancer chemotherapy presents relevant limitations associated with the non-selectivity of cytotoxic drugs, their narrow therapeutic indices and limited cellular penetration. Molecularly imprinted polymers (MIP) prepared using molecular imprinted technology has the advantages such as high stability against chemical and enzymatic attack, high selectivity for a specific template, and the capability of resistance to harsh environment. In this research, the MIP with cancer antigen 125 (CA125) tumor markers as template molecule, combined with molecular imprinting technique was prepared on the surface of graphene oxide for drug delivery. As a result the prepared composite had the properties of specific binding to CA125 and biocompatibility. Along with this, the composites could target specific tumor cell by the capture of CA125. CA125-molecularly imprinted polymers as a recognition element for the tumor cell could eliminate the use of antibody, enhance stability and prolong the retention time of drugs surrounding them. Ultimately, this method developed a cost-effective and stable way to target tumor cell for drug delivery.
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Literature
1.
Anselmo AC, Mitragotri S (2017) Impact of particle elasticity on particle-based drug delivery systems. Adv Drug Deliv Rev 108:51–67CrossRef
2.
Ruoslahti E (2017) Tumor penetrating peptides for improved drug delivery. Adv Drug Deliv Rev 110:3–12CrossRef
3.
Lim EK, Chung BH, Chung SJ (2018) Recent advances in pH-sensitive polymeric nanoparticles for smart drug delivery in cancer therapy. Curr Drug Targets 19(4):300–317CrossRef
4.
Wen Y, Oh JK (2015) Intracellular delivery cellulose-based bionanogels with dual temperature/pH-response for cancer therapy. Colloids Surf B 133:246–253CrossRef
5.
Pang L, Zhang C, Qin J et al (2017) A novel strategy to achieve effective drug delivery: exploit cells as carrier combined with nanoparticles. Drug Deliv 24(1):83–91CrossRef
6.
7.
8.
Ma N, Liu J, He W et al (2017) Folic acid-grafted bovine serum albumin decorated graphene oxide: an efficient drug carrier for targeted cancer therapy. J Colloid Interface Sci 490:598–607CrossRef
9.
Sun X, Liu Z, Welsher K et al (2008) Nano-graphene oxide for cellular imaging and drug delivery. Nano Res 1(3):203–212CrossRef
10.
Jin R, Ji X, Yang Y et al (2013) Self-assembled graphene–dextran nanohybrid for killing drug-resistant cancer cells[J]. ACS Appl Mater Interfaces 5(15):7181–7189CrossRef
11.
Zhao X, Yang L, Li X et al (2015) Functionalized graphene oxide nanoparticles for cancer cell-specific delivery of antitumor drug. Bioconjug Chem 26(1):128–136CrossRef
12.
Feng F, Zheng J, Qin P et al (2017) A novel quartz crystal microbalance sensor array based on molecular imprinted polymers for simultaneous detection of clenbuterol and its metabolites. Talanta 167:94–102CrossRef
13.
Fan D, Jia L, Xiang H et al (2017) Synthesis and characterization of hollow porous molecular imprinted polymers for the selective extraction and determination of caffeic acid in fruit samples. Food Chem 224:32–36CrossRef
14.
Zhang YN, Dai W, Wen Y et al (2017) Efficient enantioselective degradation of the inactive (S)-herbicide dichlorprop on chiral molecular-imprinted TiO2. Appl Catal B 212:185–192CrossRef
15.
Xiang H, Peng M, Li H et al (2017) High-capacity hollow porous dummy molecular imprinted polymers using ionic liquid as functional monomer for selective recognition of salicylic acid. J Pharm Biomed Anal 133:75–81CrossRef
16.
Li L, Chen L, Zhang H et al (2016) Temperature and magnetism bi-responsive molecularly imprinted polymers: preparation, adsorption mechanism and properties as drug delivery system for sustained release of 5-fluorouracil. Mater Sci Eng C 61:158–168CrossRef
17.
Zhao X, Hu W, Wang Y et al (2018) Decoration of graphene with 2-aminoethanethiol functionalized gold nanoparticles for molecular imprinted sensing of erythrosine. Carbon 127:618–626CrossRef
18.
Lian W, Liang J, Shen L et al (2018) Enzymatic logic calculation systems based on solid-state electrochemiluminescence and molecularly imprinted polymer film electrodes. Biosens Bioelectron 100:326–332CrossRef
19.
20.
21.
Whitcombe MJ, Chianella I, Larcombe L et al (2011) The rational development of molecularly imprinted polymer-based sensors for protein detection. Chem Soc Rev 40(3):1547–1571CrossRef
22.
Zhou J, Gan N, Li TH (2013) Ultratrace detection of c-reactive protein by a piezoelectric immunosensor based on Fe3O4@SiO2 magnetic capture nanoprobes and hrp-antibody co-immobilized nano gold as signal tags. Sens Actuat B 178:494–500CrossRef
23.
Lee MH, Thomas JL, Chang YC et al (2016) Electrochemical sensing of nuclear matrix protein 22 in urine with molecularly imprinted poly (ethylene-co-vinyl alcohol) coated zinc oxide nanorod arrays for clinical studies of bladder cancer diagnosis. Biosens Bioelectron 79:789–795CrossRef
24.
Zhang Z, Li J, Fu L et al (2015) Magnetic molecularly imprinted microsensor for selective recognition and transport of fluorescent phycocyanin in seawater. J Mater Chem A 3(14):7437–7444CrossRef
25.
Öncel P, Çetin K, Topçu AA et al (2017) Molecularly imprinted cryogel membranes for mitomycin C delivery. J Biomater Sci Polym Ed 28(6):519–531CrossRef
26.
Paul PK, Treetong A, Suedee R (2017) Biomimetic insulin-imprinted polymer nanoparticles as a potential oral drug delivery system. Acta Pharm 67(2):149–168CrossRef
27.
Liu L, Xu H, Wang W et al (2015) A preoperative serum signature of CEA+/CA125+/CA199 ≥ 1000 U/mL indicates poor outcome to pancreatectomy for pancreatic cancer. Int J Cancer 136(9):2216–2227CrossRef
28.
Zhu Y, Murali S, Cai W et al (2010) Graphene and graphene oxide: synthesis, properties, and applications. Adv Mater 22(35):3906–3924CrossRef
29.
Song E, Han W, Li C et al (2014) Hyaluronic acid-decorated graphene oxide nanohybrids as nanocarriers for targeted and pH-responsive anticancer drug delivery. ACS Appl Mater Interfaces 6(15):11882–11890CrossRef
30.
Liang P, Liu CJ, Zhuo RX et al (2013) Self-assembled inorganic/organic hybrid nanoparticles with multi-functionalized surfaces for active targeting drug delivery. J Mater Chem B 1(34):4243–4250CrossRef
31.
Ma RT, Ha W, Chen J et al (2016) Highly dispersed magnetic molecularly imprinted nanoparticles with well-defined thin film for the selective extraction of glycoprotein. J Mater Chem B 4(15):2620–2627CrossRef
32.
Han S, Li X, Wang Y et al (2015) Multifunctional imprinted polymers based on CdTe/CdS and magnetic graphene oxide for selective recognition and separation of pt-octylphenol. Chem Eng J 271:87–95CrossRef
33.
Han S, Li X, Wang Y et al (2015) Graphene oxide-based fluorescence molecularly imprinted composite for recognition and separation of 2, 4, 6-trichlorophenol. RSC Adv 5(3):2129–2136CrossRef
34.
Karfa P, Roy E, Patra S et al (2016) A fluorescent molecularly-imprinted polymer gate with temperature and pH as inputs for detection of alpha-fetoprotein. Biosens Bioelectron 78:454–463CrossRef
35.
Zhao X, Liu L, Li X et al (2014) Biocompatible graphene oxide nanoparticle-based drug delivery platform for tumor microenvironment-responsive triggered release of doxorubicin. Langmuir 30(34):10419–10429CrossRef
36.
Gong MQ, Wu JL, Chen B et al (2015) Self-assembled polymer/inorganic hybrid nanovesicles for multiple drug delivery to overcome drug resistance in cancer chemotherapy. Langmuir 31(18):5115–5122CrossRef
37.
Parisi OI, Morelli C, Puoci F et al (2014) Magnetic molecularly imprinted polymers (MMIPs) for carbazole derivative release in targeted cancer therapy. J Mater Chem B 2(38):6619–6625CrossRef
Metadata
Title
A molecularly imprinted composite based on graphene oxide for targeted drug delivery to tumor cells
Authors
Shuang Han
Liqiang Su
Minghui Zhai
Lin Ma
Shiwei Liu
Yue Teng
Publication date
19-10-2018
Publisher
Springer US
Published in
Journal of Materials Science / Issue 4/2019
Print ISSN: 0022-2461
Electronic ISSN: 1573-4803
DOI
https://doi.org/10.1007/s10853-018-3023-8

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