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Neuroinformatics

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01-01-2014 | Original Article

A Neuroinformatics of Brain Modeling and its Implementation in the Brain Operation Database BODB

Authors: Michael A. Arbib, Anon Plangprasopchok, James Bonaiuto, Robert E. Schuler

Published in: Neuroinformatics | Issue 1/2014

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Abstract

We present principles for an integrated neuroinformatics framework which makes explicit how models are grounded on empirical evidence, explain (or not) existing empirical results and make testable predictions. The new ontological framework makes explicit how models bring together structural, functional, and related empirical observations. We emphasize schematics of the model’s operation linked to summaries of empirical data (SEDs) used in both the design and testing of the model, with tests comparing SEDs to summaries of simulation results (SSRs) from the model. We stress the importance of protocols for models as well as experiments. We complement the structural ontology of nested brain structures with a functional ontology of Brain Operating Principles (BOPs) for observed neural function and an ontological framework for grounding models in empirical data. We present an implementation of this ontological framework in the Brain Operation Database (BODB), an environment in which modelers and experimentalists can work together by making use of their shared empirical data, models and expertise.

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Title: A Neuroinformatics of Brain Modeling and its Implementation in the Brain Operation Database BODB
Authors: Michael A. Arbib
Anon Plangprasopchok
James Bonaiuto
Robert E. Schuler
Publication date: 01-01-2014
Publisher: Springer US
Published in: Neuroinformatics / Issue 1/2014
Print ISSN: 1539-2791
Electronic ISSN: 1559-0089
DOI: https://doi.org/10.1007/s12021-013-9209-y

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