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Experiments in Fluids

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01-06-2021 | Research Article

A novel technique towards investigating wall shear stress within the stent struts using particle image velocimetry

Authors: Navid Freidoonimehr, Maziar Arjomandi, Anthony Zander, Rey Chin

Published in: Experiments in Fluids | Issue 6/2021

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Abstract

Understanding the effects of a stent design on the flow behaviour especially near the artery wall can lead to choosing or designing more haemodynamically compatible stents that can reduce the chances of restenosis inside the stented arteries. In this study, a novel technique is presented for the visualisation of the entire flow and the investigation of wall shear stress (WSS) within the stent struts without covering the field of view (FOV) inside a stented coronary artery model using particle image velocimetry. This novel technique is based on the construction of a transparent stented artery using silicone casted in one piece, instead of inserting a metal or non-metallic stent inside a casted artery model, which are translucent and distort the FOV. The effect of the stent pattern on the WSS and oscillatory shear index of a coronary artery is investigated for the models of four stents to identify the locations with the high chances of restenosis. The developed technique will help to improve the stent designs to achieve better patient outcome.

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Beier S, Ormiston J, Webster M et al (2016) Hemodynamics in idealized stented coronary arteries: important stent design considerations. Ann Biomed Eng 44:315–329. https://doi.org/10.1007/s10439-015-1387-3CrossRef

Berry JL, Santamarina A, Moore JE, Roychowdhury S, Routh WD (2000) Experimental and computational flow evaluation of coronary stents. Ann Biomed Eng 28:386–398. https://doi.org/10.1114/1.276CrossRef

Brindise MC, Chiastra C, Burzotta F, Migliavacca F, Vlachos PP (2017) Hemodynamics of stent implantation procedures in coronary bifurcations: an in vitro study. Ann Biomed Eng 45:542–553. https://doi.org/10.1007/s10439-016-1699-yCrossRef

Charonko JJ, Vlachos PP (2013) Estimation of uncertainty bounds for individual particle image velocimetry measurements from cross-correlation peak ratio. Meas Sci Technol 24:065301. https://doi.org/10.1088/0957-0233/24/6/065301CrossRef

Charonko J, Karri S, Schmieg J, Prabhu S, Vlachos P (2009) In vitro, time-resolved PIV comparison of the effect of stent design on wall shear stress. Ann Biomed Eng 37:1310–1321. https://doi.org/10.1007/s10439-009-9697-yCrossRef

Charonko J, Karri S, Schmieg J, Prabhu S, Vlachos P (2010) In vitro comparison of the effect of stent configuration on wall shear stress using time-resolved particle image velocimetry. Ann Biomed Eng 38:889–902. https://doi.org/10.1007/s10439-010-9915-7CrossRef

Chatzizisis YS, Coskun AU, Jonas M, Edelman ER, Feldman CL, Stone PH (2007) Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior. J Am Coll Cardiol 49:2379–2393. https://doi.org/10.1016/j.jacc.2007.02.059CrossRef

Chatzizisis YS, Jonas M, Coskun AU et al (2008) Prediction of the localization of high-risk coronary atherosclerotic plaques on the basis of low endothelial shear stress: an intravascular ultrasound and histopathology natural history study. Circulation 117:993–1002. https://doi.org/10.1161/circulationaha.107.695254CrossRef

Chiastra C, Dubini G, Migliavacca F (2020) Chapter 11—Hemodynamic perturbations due to the presence of stents. In: Ohayon J, Finet G, Pettigrew RI (eds) Biomechanics of coronary atherosclerotic plaque. Academic Press, pp 257–278

Chiastra C, Migliavacca F, Martínez MÁ, Malvè M (2014) On the necessity of modelling fluid–structure interaction for stented coronary arteries. J Mech Behav Biomed Mater 34:217–230. https://doi.org/10.1016/j.jmbbm.2014.02.009CrossRef

Davies JE, Parker KH, Francis DP, Hughes AD, Mayet J (2008) What is the role of the aorta in directing coronary blood flow? Heart 94:1545–1547. https://doi.org/10.1136/hrt.2008.144808CrossRef

Dodge JT, Brown BG, Bolson EL, Dodge HT (1992) Lumen diameter of normal human coronary arteries. Influence of age, sex, anatomic variation, and left ventricular hypertrophy or dilation. Circulation 86:232–246. https://doi.org/10.1161/01.cir.86.1.232CrossRef

Foin N, Lu S, Ng J et al (2017) Stent malapposition and the risk of stent thrombosis: mechanistic insights from an in vitro model. EuroIntervention 13:e1096–e1098. https://doi.org/10.4244/eij-d-17-00381CrossRef

Freidoonimehr N, Arjomandi M, Sedaghatizadeh N, Chin R, Zander A (2020a) Transitional turbulent flow in a stenosed coronary artery with a physiological pulsatile flow. Int J Numer Methods Biomed Eng 36:e3347. https://doi.org/10.1002/cnm.3347MathSciNetCrossRef

Freidoonimehr N, Chin R, Zander A, Arjomandi M (2020b) An experimental model for pressure drop evaluation in a stenosed coronary artery. Phys Fluids 32:021901. https://doi.org/10.1063/1.5139701CrossRef

García Carrascal P, García García J, Sierra Pallares J, Castro Ruiz F, Manuel Martín FJ (2018) Benchmark for numerical models of stented coronary bifurcation flow. J Biomech Eng 140:091009. https://doi.org/10.1115/1.4039676CrossRef

García García J, García Carrascal P, Castro Ruiz F, Manuel Martín F, Fernández JA (2017) Effects of bifurcation-specific and conventional stents on coronary bifurcation flow. An experimental and numerical study. J Biomech 54:64–72. https://doi.org/10.1016/j.jbiomech.2017.01.043CrossRef

Gijsen F, Katagiri Y, Barlis P et al (2019) Expert recommendations on the assessment of wall shear stress in human coronary arteries: existing methodologies, technical considerations, and clinical applications. Eur Heart J 40:3421–3433. https://doi.org/10.1093/eurheartj/ehz551%JEuropeanHeartJournalCrossRef

Jiménez JM, Davies PF (2009) Hemodynamically driven stent strut design. Ann Biomed Eng 37:1483–1494. https://doi.org/10.1007/s10439-009-9719-9CrossRef

Johnston ID, McCluskey D, Tan C, Tracey M (2014) Mechanical characterization of bulk Sylgard 184 for microfluidics and microengineering. J Micromech Microeng 24:035017CrossRef

Kastrati A, Mehilli J, Dirschinger J et al (2001a) Intracoronary stenting and angiographic results. Circulation 103:2816–2821. https://doi.org/10.1161/01.CIR.103.23.2816CrossRef

Kastrati A, Mehilli J, Dirschinger J et al (2001b) Restenosis after coronary placement of various stent types. Am J Cardiol 87:34–39. https://doi.org/10.1016/s0002-9149(00)01268-6CrossRef

Koskinas KC, Chatzizisis YS, Antoniadis AP, Giannoglou GD (2012) Role of endothelial shear stress in stent restenosis and thrombosis. Pathophysiol Mech Implic Clin Transl 59:1337–1349. https://doi.org/10.1016/j.jacc.2011.10.903CrossRef

Ku DN (1997) Blood flow in arteries. Annu Rev Fluid Mech 29:399–434. https://doi.org/10.1146/annurev.fluid.29.1.399MathSciNetCrossRef

Lee SW, Lee SS (2008) Shrinkage ratio of PDMS and its alignment method for the wafer level process. Microsyst Technol 14:205–208. https://doi.org/10.1007/s00542-007-0417-yCrossRef

Leonardi S, Orlandi P, Antonia RA (2007) Properties of d- and k-type roughness in a turbulent channel flow. Phys Fluids 19:125101. https://doi.org/10.1063/1.2821908CrossRefMATH

MacDonald M, Chan L, Chung D, Hutchins N, Ooi A (2016) Turbulent flow over transitionally rough surfaces with varying roughness densities. J Fluid Mech 804:130–161. https://doi.org/10.1017/jfm.2016.459MathSciNetCrossRef

McKittrick CM, Cardona MJ, Black RA, McCormick C (2020) Development of a bioactive polymeric drug eluting coronary stent coating using electrospraying. Ann Biomed Eng 48:271–281. https://doi.org/10.1007/s10439-019-02346-6CrossRef

Mejia J, Ruzzeh B, Mongrain R, Leask R, Bertrand OF (2009) Evaluation of the effect of stent strut profile on shear stress distribution using statistical moments. Biomed Eng Online 8:8. https://doi.org/10.1186/1475-925X-8-8CrossRef

Morlacchi S, Keller B, Arcangeli P et al (2011) Hemodynamics and in-stent restenosis: micro-CT images, histology, and computer simulations. Ann Biomed Eng 39:2615. https://doi.org/10.1007/s10439-011-0355-9CrossRef

Müller A, Wapler MC, Wallrabe U (2019) A quick and accurate method to determine the Poisson’s ratio and the coefficient of thermal expansion of PDMS. Soft Matter 15:779–784. https://doi.org/10.1039/C8SM02105HCrossRef

Natarajan S, Mokhtarzadeh-Dehghan MR (2000) A numerical and experimental study of periodic flow in a model of a corrugated vessel with application to stented arteries. Med Eng Phys 22:555–566. https://doi.org/10.1016/S1350-4533(00)00072-2CrossRef

Ng J, Bourantas CV, Torii R et al (2017) Local hemodynamic forces after stenting: implications on restenosis and thrombosis. Arterioscler Thromb Vasc Biol 37:2231–2242. https://doi.org/10.1161/atvbaha.117.309728CrossRef

Nichols W, O’Rourke M, Vlachopoulos C (2011) McDonald’s blood flow in arteries: theoretical, experimental and clinical principles, 6th edn. CRC Press

Pache J, Kastrati A, Mehilli J et al (2003) Intracoronary stenting and angiographic results: strut thickness effect on restenosis outcome (ISAR-STEREO-2) trial. J Am Coll Cardiol 41:1283–1288. https://doi.org/10.1016/s0735-1097(03)00119-0CrossRef

Pinto SIS, Romano E, António CC, Sousa LC, Castro CF (2020) The impact of non-linear viscoelastic property of blood in right coronary arteries hemodynamics—a numerical implementation. Int J Non-Linear Mech 123:103477. https://doi.org/10.1016/j.ijnonlinmec.2020.103477CrossRef

Raben JS, Morlacchi S, Burzotta F, Migliavacca F, Vlachos PP (2015) Local blood flow patterns in stented coronary bifurcations: an experimental and numerical study. J Appl Biomater Funct Mater 13:116–126. https://doi.org/10.5301/jabfm.5000217CrossRef

Tarrahi I, Colombo M, Hartman EMJ et al (2020) Impact of bioresorbable scaffold design characteristics on local hemodynamic forces—an ex vivo assessment with computational fluid dynamics simulations. EuroIntervention 16:930–937CrossRef

William Thielicke EJS (2014) PIVlab—towards user-friendly, affordable and accurate digital particle image velocimetry in MATLAB. J Open Res Softw 2:330. https://doi.org/10.5334/jors.blCrossRef

Title: A novel technique towards investigating wall shear stress within the stent struts using particle image velocimetry
Authors: Navid Freidoonimehr
Maziar Arjomandi
Anthony Zander
Rey Chin
Publication date: 01-06-2021
Publisher: Springer Berlin Heidelberg
Published in: Experiments in Fluids / Issue 6/2021
Print ISSN: 0723-4864
Electronic ISSN: 1432-1114
DOI: https://doi.org/10.1007/s00348-021-03230-7

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