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2019 | OriginalPaper | Chapter

1. A Review of Bioreactors and Mechanical Stimuli

Authors : Marzia Brunelli, Cécile Perrault, Damien Lacroix

Published in: Multiscale Mechanobiology in Tissue Engineering

Publisher: Springer Singapore

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Abstract

The increased need to accelerate the healing process of critical size defects in the bone led to the study of optimal combination of cells, materials and external stimuli to obtain fully differentiated tissue to the injured site. Bioreactors play a crucial role in the control over the development of functional tissue allowing control over the surrounding chemical and mechanical environment. This chapter aims to review bioreactor systems currently available for monitoring mesenchymal stem cells (MSCs) behaviour under mechanical stimuli and to give an insight of their effect on cellular commitment. Shear stress, mechanical strain and pulsed electromagnetic field bioreactors are presented, and the effect of multiple conditions under varying parameters such as amplitude, frequency or duration of the stimuli on bone progenitor cells differentiation is considered and extensively discussed with particular focus on osteogenic and chondrogenic commitment.

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next chapter Multiscale Simulation of Bioreactor Design and In Vitro Conditions

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Title: A Review of Bioreactors and Mechanical Stimuli
Authors: Marzia Brunelli
Cécile Perrault
Damien Lacroix
Publisher: Springer Singapore
Book: Multiscale Mechanobiology in Tissue Engineering
Print ISBN: 978-981-10-8074-6

Electronic ISBN: 978-981-10-8075-3

Copyright Year: 2019
DOI: https://doi.org/10.1007/978-981-10-8075-3_1

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