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Polymer Bulletin
Published in: Polymer Bulletin 2/2023

07-03-2022 | Original Paper

Aminolysis of poly(hydroxybutyrate)-based multicomponent films for the impregnation of bovine serum albumin

Authors: Zulfiqar Ali Raza, Shanza Khalil, Muhammad Irfan Majeed, Tanzeel Sarwar

Published in: Polymer Bulletin | Issue 2/2023

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Abstract

Chemical modification of native biopolymers may introduce in them some new surface functionalities for the controlled loading/release of foreign species of biomedical significance such as drugs, proteins, cellular metabolites, etc. The present study undertakes the preparation of poly(caprolactone) mediated poly(hydroxybutyrate) (PHB) multicomponent films with poly(lactic acid) as a plasticizer. The prepared films were surface chemical functionalized with amino groups using the ethylenediamine in aqueous or organic media; the process is called aminolysis. The aminolyzed multicomponent films contained active hydrophilic groups offering opportunities for the immobilization of bovine serum albumin (BSA, as a model protein). The extent of aminolysis was tracked using ninhydrin assay, and the prepared films were further characterized using contact angle measurement, Fourier transform infrared spectroscopy, scanning electron microscopy, thermal analysis, x-ray diffraction, and Raman spectroscopy. The results demonstrated the successful formation and aminolysis of PHB-based multicomponent films with desirable amino-hydrophilicity for controlled impregnation and release of BSA.
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Literature
1.
Guo W, Yanf Z, Qin X et al (2021) Fabrication and characterization of the core-shell structure of poly(3-hydroxybutyrate-4-hydroxybutyrate) nanofiber scaffolds. Biomed Res Int 2021:8868431
2.
Zihayat B, Shakibaie M, Sabouri-Shahrbabak S et al (2019) Medium optimization for polyhydroxyalkanoate production by Pseudomonas pseudoalcaligenes strain Te using D-optimal design. Biocat Agric Biotechnol 18:101001.
3.
Raza ZA, Khalil S, Abid S (2020) Recent progress in development and chemical modification of poly(hydroxybutyrate) based blends for potential medical applications. Int J Biol Macromol 160:77–100CrossRef
4.
Manikandan N, Pakshirajan K, Pugazhenthi G (2020) Preparation and characterization of environmentally safe and highly biodegradable microbial polyhydroxybutyrate (PHB) based graphene nanocomposites for potential food packaging applications. Int J Biol Macromol 154:866–877CrossRef
5.
Garcia D, Ferri JM, Boronat T et al (2016) Processing and characterization of binary poly(hydroxybutyrate) (PHB) and poly(caprolactone) (PCL) blends with improved impact properties. Polym Bull 73:3333–3350CrossRef
6.
Bonartsev A, Zharkova I, Yakovlev S et al (2016) 3D-scaffolds from poly(3-hydroxybutyrate) poly(ethylene glycol) copolymer for tissue engineering. J Biomater Tissue Eng 6:42–52CrossRef
7.
Balla E, Daniilidis V, Karlioti G et al (2021) Poly(lactic acid): a versatile biobased polymer for the future with multifunctional properties—from monomer synthesis, polymerization techniques and molecular weight increase to PLA applications. Polym 13:1822CrossRef
8.
Xue J, He M, Liu H et al (2014) Drug loaded homogeneous electrospun PCL/gelatin hybrid nanofiber structures for anti-infective tissue regeneration membranes. Biomater 35:9395–9405CrossRef
9.
Ansari Z, Kalantar M, Kharaziha M, et al (2020) Polycaprolactone/fluoride substituted-hydroxyapatite (PCL/FHA) nanocomposite coatings prepared by in-situ sol-gel process for dental implant applications. Prog Org Coat 147:105873.
10.
Siddiqui N, Asawa S, Birru B et al (2018) PCL-based composite scaffold matrices for tissue engineering applications. Mol Biotechnol 60:506–532CrossRef
11.
Plavec R, Hlavacikova S, Omanikova L et al (2020) Recycling possibilities of bioplastics based on PLA/PHB blends. Polym Test 92:106880.
12.
Yeo JCC, Muiruri JK, Tan BH et al (2018) Biodegradable PHB-rubber copolymer toughened PLA green composites with ultrahigh extensibility. ACS Sustain Chem Eng 6:15517–15527CrossRef
13.
Wua L, Shresthab P, Iapichinob M (2021) Characterization method for calculating diffusion coefficient of drug from polylactic acid (PLA) microneedles into the skin. J Drug Deliv Sci Technol 61:102192.
14.
Gardner D, Aydemir D (2020) Biopolymer blends of polyhydroxybutyrate and polylactic acid reinforced with cellulose nanofibrils. Carbohydr Polym 250:116867.
15.
Yoon YI, Moon HS, Lyoo WS et al (2008) Superhydrophobicity of PHBV fibrous surface with bead-on-string structure. J Colloid Interface Sci 320:91–95CrossRef
16.
Bonartsev AP, Voinova VV, Kuznetsova ES et al (2018) BSA adsorption on porous scaffolds prepared from bioPEGylated poly(3-hydroxybutyrate). Appl Biochem Microbiol 54:379–386CrossRef
17.
Vigneswari S, Murugaiyah V, Kaur G et al (2016) Biomacromolecule immobilization: grafting of fish-scale collagen peptides onto aminolyzed P(3HB-co-4HB) scaffolds as a potential wound dressing. Biomed Mater 11:055009.
18.
Gittens RA, Scheideler L, Rupp F et al (2014) A review on the wettability of dental implant surfaces II: biological and clinical aspects. Acta Biomater 10:2907–2918CrossRef
19.
Raza ZA, Noor S, Majeed MI (2021) PEGylation of poly(hydroxybutyrate) into multicomponent nanostructures and loading thereon with bioactive molecules for potential biomedical applications. J Polym Res 28:118CrossRef
20.
Zhu Y, Gao C, Liu X et al (2002) Surface modification of polycaprolactone membrane via aminolysis and biomacromolecule immobilization for promoting cytocompatibility of human endothelial cells. Biomacromol 3:1312–1319CrossRef
21.
Rodríguez-Alba E, Dionisio N, Calixto M et al (2020) Surface modification of polyethylenterephthalate film with primary amines using gamma radiation and aminolysis reaction for cell adhesion studies. Radiat Phys Chem 176:109070.
22.
Chen Y, Hung S-T, Chou E et al (2018) Review of polyhydroxyalkanoates materials and other biopolymers for medical applications. Mini Rev Org Chem 15:105–121CrossRef
23.
Raza ZA, Anwar F, Hussain I et al (2019) Fabrication of PLA incorporated chitosan nanoparticles to create enhanced functional properties of cotton fabric. Pigment Resin Technol 48:169–177CrossRef
24.
García JM, Garrido I, López L et al (2013) The surface modification of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) copolymers to improve the attachment of urothelial cells. Mater Sci Eng C 33:362–369CrossRef
25.
Zhu Y, Mao Z, Shi H et al (2012) In-depth study on aminolysis of poly(ɛ-caprolactone): Back to the fundamentals. Sci China Chem 55:2419–2427CrossRef
26.
Manah NSA, Sulaiman L, NLSM Azman et al (2019) Colour analysis of organic synthetic dye coating paint films consisting 4-hydroxycoumarin derivatives after exposed to UV-A. Mater Res Express 6:076418.
27.
Costanzo GD, Ribba L, Goyanes S et al (2014) Enhancement of the optical response in a biodegradable polymer/azo-dye film by the addition of carbon nanotubes. J Phys D 47:135103.
28.
Bakare RA, Bhan C, Raghavan D (2014) Synthesis and characterization of collagen grafted poly(hydroxybutyrate-valerate) (PHBV) scaffold for loading of bovine serum albumin capped silver (Ag/BSA) nanoparticles in the potential use of tissue engineering application. Biomacromol 15:423–435CrossRef
29.
Gurler EB, Ergul NM, Ozbek B, Ekren N, Oktar FN, Haskoylu ME, Korkut V (2019) Encapsulated melatonin in polycaprolactone (PCL) microparticles as a promising graft material. Mater Sci Eng, C 100:798–808CrossRef
30.
Abdelwahab MA, Ahmed A, El-Said KS et al (2019) Evaluation of antibacterial and anticancer properties of poly(3-hydroxybutyrate) functionalized with different amino compounds. Int J Biol Macromol 122:793–805CrossRef
31.
32.
Lopusiewicz L, Jędra F, Mizielińska M (2018) New poly(lactic acid) active packaging composite films incorporated with fungal melanin. Polymers (Basel) 10:386CrossRef
33.
Jiang X, Luo Y, Tian X et al (2010) Chemical structure of poly(lactic acid). In: Auras R, Lim L-T, Selke SEM et al (eds) Poly(lactic acid): synthesis, structures, properties, processing, and applications. Wiley, New York, pp 67–82.
34.
Jeong H, Rho J, Shin J-Y, Lee DY, Hwang T, Kim KJ (2018) Mechanical properties and cytotoxicity of PLA/PCL films. Biomed Eng Lett 8(3):267–272CrossRef
35.
Arrieta MP, López J, López D et al (2015) Development of flexible materials based on plasticized electrospun PLA-PHB blends: Structural, thermal, mechanical and disintegration properties. Eur Polym J 73:433–446CrossRef
36.
Wang J, Wu Y, Cao Y et al (2020) Influence of surface roughness on contact angle hysteresis and spreading work. Colloid Polym Sci 298:1107–1112CrossRef
37.
Surmenev R, Chernozem R, Syromotina D et al (2019) Low-temperature argon and ammonia plasma treatment of poly-3-hydroxybutyrate films: Surface topography and chemistry changes affect fibroblast cells in vitro. Eur Polym J 112:137–145CrossRef
38.
Kreader CA (1996) Relief of amplification inhibition in PCR with bovine serum albumin or T4 gene 32 proteins. Appl Environ Microbiol 62(3):1102–1106CrossRef
39.
Zhang L, Xiong C, Deng X (1996) Miscibility, crystallization and morphology of poly(β-hydroxybutyrate)/poly(d, l-lactide) blends. Polym 37:235–241CrossRef
40.
Abdelwahab MA, Flynn A, Chiou BS et al (2012) Thermal, mechanical and morphological characterization of plasticized PLA-PHB blends. Polym Degrad Stab 97:1822–1828CrossRef
41.
Hinuber C, Haussler L, Vogel R et al (2011) Hollow fibers made from a poly(3-hydroxybutyrate)/poly-e-caprolactone blend. Polym Lett 5:643–652CrossRef
42.
Li F, Tian F, Liu CJ, Zhao YL (2009) Preparation and characterization of improved microspheres containing bovine serum albumin. J Appl Polym Sci 114:818–825CrossRef
43.
Cao K, Liu Y, Olkhov A, Siracusa V, Iordanskii A (2018) PLLAPHB fiber membranes obtained by solvent-free electrospinning for short-time drug delivery. Drug Deliv Transl Res 8:291–302CrossRef
44.
Raza ZA, Khatoon R, Banat MI (2021) Altering the hydrophobic/hydrophilic nature of bioplastic surfaces for biomedical applications. In: Kuddus M, Roohi (eds) Bioplastics for sustainable development. Springer, Singapore, pp 431–466
Metadata
Title
Aminolysis of poly(hydroxybutyrate)-based multicomponent films for the impregnation of bovine serum albumin
Authors
Zulfiqar Ali Raza
Shanza Khalil
Muhammad Irfan Majeed
Tanzeel Sarwar
Publication date
07-03-2022
Publisher
Springer Berlin Heidelberg
Published in
Polymer Bulletin / Issue 2/2023
Print ISSN: 0170-0839
Electronic ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-022-04165-7

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