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Published in:
Mathematical and Physical Modeling Principles of Complex Biological Systems Read chapter Read first chapter

2019 | OriginalPaper | Chapter

Anatomy and Physiology of the Cerebrospinal Fluid

Authors : David Fleischman, John Berdahl

Published in: Ocular Fluid Dynamics

Publisher: Springer International Publishing

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Abstract

The cerebrospinal fluid (CSF) is the primary circulating fluid of the central nervous system. It serves numerous important physiologic and maintenance functions, and its production and movement are highly regulated. Herein, we describe the key anatomic structures of importance in regard to CSF production, circulation, and absorption, followed by the regulatory mechanisms responsible for its proper functioning.

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previous chapter Mathematical Models of the Tear Film
next chapter Pathological Consequences of Reduced Cerebrospinal Fluid Pressure: Experimental Studies
Literature
1.
Felten D, Jozefowicz R. Netter’s Atlas of Human Neuroscience. 2003. 1st ed. Elsevier Health Sciences.
2.
Kiernan J. Barrs The Human Nervous System: An Anatomical Viewpoint. 2005. 8th Ed. Lippincott Williams & Wilkins.
3.
Purves D, Augustine G, Fitzpatrick D, Katz L, LaMantia A-S, McNamara J, Williams S. Neuroscience. 2001. 2nd ed. Sinauer Associates, Inc. Sunderland, Massachusetts.
4.
Redzic ZB, Preston JE, Duncan JA, Chodobski A, Szmydynger-Chodobska J. The choroid plexus cerebrospinal fluid system: from development to aging. Curr Top Dev Biol 2005 71: 1–52
5.
Last R, Tompsett D. Casts of the cerebral ventricles. Brit J Surg 1953. 40:525-543CrossRef
6.
Matys T, Horsburgh A, Kirollos R, Massoud T. The Aqueduct of Sylvius: Applied 3-T magnetic resonance imaging anatomy and morphometry with neuroendoscopic relevance. Neurosurgery 2013: 73(ONS Suppl 2):ons132-ons140CrossRef
7.
Woodlam DH, Millen JW. Anatomical considerations in the pathology of stenosis of the cerebral aqueduct. Brain 1953:76(1):104-12.CrossRef
8.
Mollanji R, Bozanovic-Sosic R, Zakharov A, Makarian L, Johnston M. Blocking cerebrospinal fluid absorption through the cribriform plate increases resting intracranial pressure. Am J Physiol Regul Integr Comp Physiol. 2002. 282(6):R1593-9.CrossRef
9.
Rammling M, Madan M, Paul L, Behnam B, Pattisapu JV. Evidence for reduced lymphatic CSF absorption in the H-Tx rat hydrocephalus model. Cerebrospinal Fluid Res. 2008 Oct 16;5:15CrossRef
10.
Brierly JB, Field EJ. The connexions of the spinal subarachnoid space with the lymphatic system. Jl Anat. 1948. 82: 153-66.
11.
Bozanovic-Sosic R, Mollanji R, Johnston MG. Spinal and cranial contributions to total cerebrospinal fluid transport. J Physiol Regul Integr Comp Physiol 2001 281(3): R909-16.CrossRef
12.
Leach J, Jones B, Tomsick T, Stewart C, Balko M. Normal appearance of arachnoid granulations on contrast-enhanced CT and MR of the brain: differentiation from dural sinus disease. AJNR Am J Neuroradiol 1996. 17: 1523-32.
13.
LeGros Clark W. On the pacchionian bodies. J Anat. 1920. 55:40-8.
14.
Davson H, Segal M. Physiology of the CSF and Blood-Brain Barriers. 1995. 1st Ed. CRC Press.
15.
Pollay M. The function and structure of the cerebrospinal fluid outflow system. Cerebrospinal Fluid Res 2010 21(7):9
16.
Bloomfield I, Johnston I, Bilston L. Effects of proteins, blood cells and glucose on the viscosity of cerebrospinal fluid. Pediatr Neurosurg 1998 May;28(5):246-51CrossRef
17.
Burris CA, Ashwood ER, Burns DE. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 4th ed. 2006. St Louis: Elsevier Saunders. 1633:962-967
18.
Kaplan Pesce. Clinical Chemistry: Theory, Analysis, Correlation. 5th ed. 2010. St. Louis, MO: Elsevier, Inc; 904-928.
19.
Lui A, Polis T, Cicutti N. Densities of cerebrospinal fluid and spinal anaesthetic solution in surgical patients at body temperature. Can J Anaesth. 1998 45(4):297-303CrossRef
20.
Spector R, Snodgrass S, Johanson C. A balanced view of the cerebrospinal fluid composition and functions: Focus on adult humans. Exp Neurol. 2015. 273:57-68.CrossRef
21.
Brown P, Davies S, Speake T, Millar I. Molecular mechanisms of cerebrospinal fluid production. Neuroscience 2004 129: 957-70.CrossRef
22.
May C, Kaye JA, Atack JR, Schapiro MB, Friedland RP, Rapoport SI. Cerebrospinal fluid production is reduced in healthy aging. Neurology. 1990. 40(3 Pt 1):500-3.CrossRef
23.
Sakka L, Coll G, Chazal J. Anatomy and physiology of cerebrospinal fluid. Eur Ann Otorhinolayngol Head Neck Dis. 2011 128(6):309-16.CrossRef
24.
Spector R, Snodgrass S, Johanson C. A balanced view of the cerebrospinal fluid composition and functions: Focus on adult humans. Exp Neurol. 2015. 273:57-68.CrossRef
25.
Fleischman D, Berdahl J, Zaydlarova J, Stinnett S, Fautsch M, Allingham R. Cerebrospinal fluid pressure decreases with older age. PLoS One. 2012 7(12):e52664.CrossRef
26.
Samuels B, Hammes N, Johnson P, Shekhar A, McKinnon S, Allingham R. Dorsomedial/perifornical hypothalamic stimulation increases intraocular pressure, intracranial pressure, and the translaminar pressure gradient. Invest Ophthalmol Vis Sci. 2012 53(11):7328-35.CrossRef
27.
Spector R, Keep R, Snodgrass S, Smith Q, Johanson C. A balanced view of choroid plexus structure and function: Focus on adult humans. Exp Neurol. 2015. 267:78-86.CrossRef
28.
Alperin N, Lee S, Sivaramakrishnan A, Hushek S. Quantifying the effect of posture on intracranial physiology in humans by MRI flow studies. Journal of Magnetic Resonance Imaging. 2005. 22:591-6.CrossRef
29.
Cserr HF, Harling-Berg CJ, Knopf PM: Drainage of brain extracellular fluid into blood and deep cervical lymph and its immunological significance. Brain Pathol 1992 4:269-76.CrossRef
30.
Jessen N, Munk A, Lundgaard, Nedergaard M. The glymphatic system – a beginner’s guide. Neurochem Res. 2015 40(12): 2583-99.CrossRef
31.
Lee H, Xie L, Yu M, Kang H, Feng T, Deane R, Logan J, Nedergaard M, Benveniste H. The effect of body posture on brain glymphatic transport. J of Neuroscience 2015: 35(31):11034-44.CrossRef
32.
Thiery J, Lomet D, Bougoin S, Malpoux B. Turnover rate of cerebrospinal fluid in female sheep: changes related to different light-dark cycles. Cerebrospinal Fluid Research 2009 6:9
33.
Elman R. Spinal arachnoid granulations with especial reference to the cerebrospinal fluid. Bull Johns Hopkins Hosp. 1923. 34:99.
34.
Albeck MJ, Skak C, Nielsen PR, Olsen KS, Borgesen SE, Gjerris F. Age dependency of resistance to cerebrospinal fluid outflow. J Neurosurg 1998. 89: 275–8.CrossRef
35.
Berdahl J, Fleischman D, Zaydlarova J, Stinnett S, Allingham R, Fautsch M. Body mass index has a linear relationship with cerebrospinal fluid pressure. Invest Ophthalmol Vis Sci. 2012 53(3):1422-7.CrossRef
36.
Lenfeldt N, Koskinen LOD, Bergenheim AT, Malm, J, Eklund A. CSF pressure assessed by lumbar puncture agrees with intracranial pressure. Neurology. 2007. 68:155–158CrossRef
37.
Nagra G, Johnston MG. Impact of ageing on lymphatic cerebrospinal fluid absorption in the rat. Neuropathology and Applied Neurobiology 2007 33: 684–691CrossRef
38.
Morgan WH, Yu DY, Cooper RL, Alder VA, Cringle SJ, Constable IJ. The influence of cerebrospinal fluid pressure on the lamina cribrosa tissue pressure gradient. Invest Ophthalmol Vis Sci. 1995 May; 36(6): 1163-72.
Metadata
Title
Anatomy and Physiology of the Cerebrospinal Fluid
Authors
David Fleischman
John Berdahl
Copyright Year
2019
Book
Ocular Fluid Dynamics

Print ISBN: 978-3-030-25885-6

Electronic ISBN: 978-3-030-25886-3

Copyright Year: 2019

DOI
https://doi.org/10.1007/978-3-030-25886-3_18

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