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Medical & Biological Engineering & Computing
Published in: Medical & Biological Engineering & Computing 8/2007

01-08-2007 | Review Article

Assessment of cerebrospinal fluid outflow resistance

Authors: Anders Eklund, Peter Smielewski, Iain Chambers, Noam Alperin, Jan Malm, Marek Czosnyka, Anthony Marmarou

Published in: Medical & Biological Engineering & Computing | Issue 8/2007

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Abstract

The brain and the spinal cord are contained in a cavity and are surrounded by cerebrospinal fluid (CSF), which provides physical support for the brain and a cushion against external pressure. Hydrocephalus is a disease, associated with disturbances in the CSF dynamics, which can be surgically treated by inserting a shunt or third ventriculostomy. This review describes the physiological background, modeling and mathematics, and the investigational methods for determining the CSF dynamic properties, with specific focus on the CSF outflow resistance, R out. A model of the cerebrospinal fluid dynamic system, with a pressure-independent R out, a pressure-dependent compliance and a constant formation rate of CSF is widely accepted. Using mathematical expressions calculated from the model, along with active infusion of artificial CSF and observation of corresponding change in ICP allows measurements of CSF dynamics. Distinction between normal pressure hydrocephalus and differential diagnoses, prediction of clinical response to shunting and the possibility of assessment of shunt function in vivo are the three most important applications of infusion studies in clinical practice.
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Metadata
Title
Assessment of cerebrospinal fluid outflow resistance
Authors
Anders Eklund
Peter Smielewski
Iain Chambers
Noam Alperin
Jan Malm
Marek Czosnyka
Anthony Marmarou
Publication date
01-08-2007
Publisher
Springer-Verlag
Published in
Medical & Biological Engineering & Computing / Issue 8/2007
Print ISSN: 0140-0118
Electronic ISSN: 1741-0444
DOI
https://doi.org/10.1007/s11517-007-0199-5

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