Skip to main content
Fachgebiete
Automobil + Motoren Bauwesen + Immobilien Business IT + Informatik Elektrotechnik + Elektronik Energie + Nachhaltigkeit Finance + Banking Management + Führung Marketing + Vertrieb Maschinenbau + Werkstoffe Versicherung + Risiko
DE
EN
Bücher
Zeitschriften
Themenseiten
Organisationspsychologie Projektmanagement Marketing Smart Manufacturing
Weitere Formate
Podcasts Webinare Technik Webinare Wirtschaft Kongresse Veranstaltungskalender Awards
Jetzt Einzelzugang starten
Zugang für Unternehmen
Referenzkunden
SLX-Digitalkonferenz: Zukunftswerkstatt 2024

Mehr Umsatz mit Top-Kontakten

Am 7. Mai erfahren Sie, wie Vertriebsteams Leadgenerierung, Leadnurturing und Leadstrategien effizient steuern können.
Erweiterte Suche
Anmelden
nach oben
Medical & Biological Engineering & Computing
Erschienen in: Medical & Biological Engineering & Computing 8/2007

01.08.2007 | Review Article

Assessment of cerebrospinal fluid outflow resistance

verfasst von: Anders Eklund, Peter Smielewski, Iain Chambers, Noam Alperin, Jan Malm, Marek Czosnyka, Anthony Marmarou

Erschienen in: Medical & Biological Engineering & Computing | Ausgabe 8/2007

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

The brain and the spinal cord are contained in a cavity and are surrounded by cerebrospinal fluid (CSF), which provides physical support for the brain and a cushion against external pressure. Hydrocephalus is a disease, associated with disturbances in the CSF dynamics, which can be surgically treated by inserting a shunt or third ventriculostomy. This review describes the physiological background, modeling and mathematics, and the investigational methods for determining the CSF dynamic properties, with specific focus on the CSF outflow resistance, R out. A model of the cerebrospinal fluid dynamic system, with a pressure-independent R out, a pressure-dependent compliance and a constant formation rate of CSF is widely accepted. Using mathematical expressions calculated from the model, along with active infusion of artificial CSF and observation of corresponding change in ICP allows measurements of CSF dynamics. Distinction between normal pressure hydrocephalus and differential diagnoses, prediction of clinical response to shunting and the possibility of assessment of shunt function in vivo are the three most important applications of infusion studies in clinical practice.
Vorheriger Artikel Unravelling the world of cis-regulatory elements
Nächster Artikel A newly developed tool for intra-tracheal temperature and humidity assessment in laryngectomized individuals: the Airway Climate Explorer (ACE)

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Jetzt informieren
Literatur
1.
Agren_Wilsson A, Roslin M, Eklund A, Koskinen LO, Bergenheim AT, Malm J (2003) Intracerebral microdialysis and CSF hydrodynamics in idiopathic adult hydrocephalus syndrome. J Neurol Neurosurg Psychiatry 74:217–21CrossRef
2.
Agren-Wilsson A, Eklund A, Koskinen LO, Bergenheim AT, Malm J (2005) Brain energy metabolism and intracranial pressure in idiopathic adult hydrocephalus syndrome. J Neurol Neurosurg Psychiatry 76:1088–93CrossRef
3.
Albeck MJ, Borgesen SE, Gjerris F, Schmidt JF, Sorensen PS (1991) Intracranial pressure and cerebrospinal fluid outflow conductance in healthy subjects. J Neurosurg 74:597–600
4.
Alperin N, Mazda M, Lichtor T, Lee SH (2006) From cerebrospinal fluid pulsation to noninvasive intracranial compliance and pressure measured by MRI flow studies. Curr Med Imaging Rev 2:117–129CrossRef
5.
Alperin NJ, Lee SH, Loth F, Raksin PB, Lichtor T (2000) MR-intracranial pressure (ICP): a method to measure intracranial elastance and pressure noninvasively by means of MR imaging: baboon and human study. Radiology 217:877–885
6.
Andersson N, Malm J, Backlund T, Eklund A (2005) Assessment of cerebrospinal fluid outflow conductance using constant-pressure infusion-a method with real time estimation of reliability. Physiol Meas 26:1137–1148CrossRef
7.
Avezaat CJ, Eijndhoven JHM (1984) Cerebrospinal fluid pulse pressure and craniospinal dynamics. Doctoral thesis, Academic Hospital of Rotterdam and Erasmus University
8.
Bech RA, Waldemar G, Gjerris F, Klinken L, Juhler M (1999) Shunting effects in patients with idiopathic normal pressure hydrocephalus; correlation with cerebral and leptomeningeal biopsy findings. Acta Neurochir (Wien) 141:633–639CrossRef
9.
Bech-Azeddine R, Gjerris F, Waldemar G, Czosnyka M, Juhler M (2005) Intraventricular or lumbar infusion test in adult communicating hydrocephalus? Practical consequences and clinical outcome of shunt operation. Acta Neurochir (Wien) 147:1027–1036CrossRef
10.
Boon AJ, Tans JT, Delwel EJ, Egeler-Peerdeman SM, Hanlo PW, Wurzer HA, Avezaat CJ, De_Jong DA, Gooskens RH, Hermans J (1997) Dutch normal-pressure hydrocephalus study: prediction of outcome after shunting by resistance to outflow of cerebrospinal fluid. J Neurosurg 87:687–693
11.
Borgesen SE, Albeck MJ, Gjerris F, Czosnyka M, Laniewski P (1992) Computerized infusion test compared to steady pressure constant infusion test in measurement of resistance to CSF outflow. Acta Neurochir (Wien) 119:12–16CrossRef
12.
Borgesen SE, Gjerris F (1982) The predictive value of conductance to outflow of CSF in normal pressure hydrocephalus. Brain 105:65–86CrossRef
13.
Borgesen SE, Gjerris F, Srensen SC (1978) The resistance to cerebrospinal fluid absorption in humans. A method of evaluation by lumbo-ventricular perfusion, with particular reference to normal pressure hydrocephalus. Acta Neurol Scand 57:88–96
14.
Chapman PH, Cosman ER, Arnold MA (1990) The relationship between ventricular fluid pressure and body position in normal subjects and subjects with shunts: a telemetric study. Neurosurgery 26:181–189CrossRef
15.
Cobb WS, Burns JM, Kercher KW, Matthews BD, James Norton H, Todd Heniford B (2005) Normal intraabdominal pressure in healthy adults. J Surg Res 129:231–235CrossRef
16.
Czosnyka M, Batorski L, Laniewski P, Maksymowicz W, Koszewski W, Zaworski W (1990) A computer system for the identification of the cerebrospinal compensatory model. Acta Neurochir 105:112–116CrossRef
17.
Czosnyka M, Batorski L, Roszkowski M, Tomaszewski J, Wocjan J, Walencik A, Zabolotny W (1993) Cerebrospinal compensation in hydrocephalic children. Childs Nerv Syst 9:17–22CrossRef
18.
Czosnyka M, Czosnyka Z, Momjian S, Pickard JD (2004) Cerebrospinal fluid dynamics. Physiol Meas 25:R51–R76CrossRef
19.
Czosnyka M, Czosnyka Z, Whitehouse H, Pickard JD (1997) Hydrodynamic properties of hydrocephalus shunts: United Kingdom shunt evaluation laboratory. J Neurol Neurosurg Psychiatry 62:43–50
20.
Czosnyka M, Whitehouse H, Smielewski P, Simac S, Pickard JD (1996) Testing of cerebrospinal compensatory reserve in shunted and non-shunted patients: a guide to interpretation based on an observational study. J Neurol Neurosurg Psychiatry 60:549–558
21.
Czosnyka Z, Czosnyka M, Richards HK, Pickard JD (1998) Posture-related overdrainage: comparison of the performance of 10 hydrocephalus shunts in vitro. Neurosurgery 42, 327–333; discussion 333–334
22.
Czosnyka ZH, Czosnyka M, Pickard JD (2002) Shunt testing in vivo: a method based on the data from the UK shunt evaluation laboratory 81:27–30
23.
Czosnyka ZH, Czosnyka M, Whitfield PC, Donovan T, Pickard JD (2002) Cerebral autoregulation among patients with symptoms of hydrocephalus. Neurosurgery 50:526–532; discussion 532–533
24.
Davson H, Welch K, Segal MB (1987) The physiology and pathophysiology of cerebrospinal fluid. Churchill Livingstone, New York
25.
Eide PK (2005) Assessment of childhood intracranial pressure recordings using a new method of processing intracranial pressure signals. Pediatr Neurosurg 41:122–130CrossRef
26.
Eklund A, Lundkvist B, Koskinen LOD, Malm J (2004) Infusion technique can be used to distinguish between dysfunction of a hydrocephalus shunt system and a progressive dementia. Med Biol Eng Comput 42:644–649CrossRef
27.
Ekstedt J (1977) CSF hydrodynamic studies in man. 1. Method of constant pressure CSF infusion. J Neurol Neurosurg Psychiatry 40:105–119
28.
Ekstedt J (1978) CSF hydrodynamic studies in man. 2. Normal hydrodynamic variables related to CSF pressure and flow. J Neurol Neurosurg Psychiatry 41:345–353
29.
Fishman RA (1992) Cerebrospinal fluid in diseases of the nervous system, 2nd edn. Saunders Company, Philadelphia
30.
Friden H, Ekstedt J (1982) Instrumentation for cerebrospinal fluid hydrodynamic studies in man. Med Biol Eng Comput 20:167–180CrossRef
31.
Fung YC (1993) Biomechanics mechanical properties of living tissues. 2nd edn. Springer, Heidelberg
32.
Gjerris F, Borgesen SE (1992) Patophysiology of CSF circulation. In: Crockard A, Hayward A, Hoff JT (eds) The scientific basis of clinical practice. Neurosurgery. Blackwell, Oxford, pp 146–174
33.
Gjerris F, Borgesen SE, Schmidt K, Sorensen PS, Gyring J (1986) Measurement of conductance to cerebrospinal fluid outflow by the steady-state perfusion method in patients with normal or increased intracranial pressure. In: Miller JD, Teasdale JO, Rowan SL (eds) Intracranial presssure VI. Springer, Heidelberg, pp 411–416
34.
Hakim S, Adams RD (1965) The special clinical problem symptomatic hydrocephalus with “normal” cerebrospinal fluid pressure. Observations on cerebrospinal fluid hydrodynamics. J Neurol Sci 2:117–126CrossRef
35.
Hayashi M, Handa Y, Kobayashi H, Kawano H, Ishii H, Hirose S (1991) Plateau-wave phenomenon (I). Correlation between the appearance of plateau waves and CSF circulation in patients with intracranial hypertension. Brain 114(Pt 6):2681–2691CrossRef
36.
Iddon JL, Pickard JD, Cross JJ, Griffiths PD, Czosnyka M, Sahakian BJ (1999) Specific patterns of cognitive impairment in patients with idiopathic normal pressure hydrocephalus and Alzheimer’s disease: a pilot study. J Neurol Neurosurg Psychiatry 67:723–732
37.
Johnston M, Zakharov A, Papaiconomou C, Salmasi G, Armstrong D (2004) Evidence of connections between cerebrospinal fluid and nasal lymphatic vessels in humans, non-human primates and other mammalian species. Cerebrospinal Fluid Res 1:2CrossRef
38.
Kahlon B, Sundbarg G, Rehncrona S (2002) Comparison between the lumbar infusion and CSF tap tests to predict outcome after shunt surgery in suspected normal pressure hydrocephalus. J Neurol Neurosurg Psychiatry 73:721–726CrossRef
39.
Kasprowicz M, Czosnyka Z, Czosnyka M, Momjian S, Juniewicz H, Pickard JD (2004) Slight elevation of baseline intracranial pressure after fluid infusion into CSF space in patients with hydrocephalus. Neurol Res 26:628–631CrossRef
40.
Katzman R, Hussey F (1970) A simple constant-infusion manometric test for measurement of CSF absorption. I. Rationale and method. Neurology 20:534–544
41.
Kosteljanetz M (1985) Resistance to outflow of cerebrospinal fluid determined by bolus injection technique and constant rate steady state infusion in humans. Neurosurgery 16:336–340CrossRef
42.
Loth F, Yardimci MA, Alperin N (2001) Hydrodynamic modeling of cerebrospinal fluid motion within the spinal cavity. J Biomech Eng 123:71–9CrossRef
43.
Lundkvist B, Eklund A, Koskinen LOD, Malm J (2003) An adjustable CSF shunt. Advices for clinical use. Acta Neurol Scand 108:38–42CrossRef
44.
Lundkvist B, Eklund A, Kristensen B, Fagerlund M, Koskinen LO, Malm J (2001) Cerebrospinal fluid hydrodynamics after placement of a shunt with an antisiphon device: a long-term study. J Neurosurg 94:750–756
45.
Magendie F (1842) Recherches physiologiques et cliniques sur le liquide céphalorachidien ou cérébro-spinal. Librairie Medicale de Mequigenon-Marvis Files, Paris
46.
Maksymowicz W, Czosnyka M, Koszewski W, Szymanska A, Traczewski W (1989) The role of cerebrospinal compensatory parameters in the estimation of functioning of implanted shunt system in patients with communicating hydrocephalus (preliminary report). Acta Neurochir (Wien) 101:112–116CrossRef
47.
Malm J, Eklund A (2006) Idiopatic normal pressure hydrocephalus. Pract Neurol 6:14–27CrossRef
48.
Malm J, Kristensen B, Fagerlund M, Koskinen LO, Ekstedt J (1995) Cerebrospinal fluid shunt dynamics in patients with idiopathic adult hydrocephalus syndrome. J Neurol Neurosurg Psychiatry 58:715–723
49.
Malm J, Kristensen B, Karlsson T, Fagerlund M, Elfverson J, Ekstedt J (1995) The predictive value of cerebrospinal fluid dynamic tests in patients with th idiopathic adult hydrocephalus syndrome. Arch Neurol 52:783–789
50.
Malm J, Lundkvist B, Eklund A, Koskinen LO, Kristensen B (2004) CSF outflow resistance as predictor of shunt function. A long-term study. Acta Neurol Scand 110:154–160CrossRef
51.
Marmarou A, Shulman K, Rosende RM (1978) A nonlinear analysis of the cerebrospinal fluid system and intracranial pressure dynamics. J Neurosurg 48:332–344
52.
Marmarou A, Young HF, Aygok GA, Sawauchi S, Tsuji O, Yamamoto T, Dunbar J (2005) Diagnosis and management of idiopathic normal-pressure hydrocephalus: a prospective study in 151 patients. J Neurosurg 102:987–997
53.
Mccomb JG, Davson H, Hyman S, Weiss MH (1982) Cerebrospinal fluid drainage as influenced by ventricular pressure in the rabbit. J Neurosurg 56:790–797
54.
Meier U, Kiefer M, Sprung C (2003) Normal-pressure hydrocephalus—pathology, pathophysiology, diagnostics, therapeutics and clinical course. PVV Science Publications, Ratingen
55.
Meier U, Zeilinger FS, Kintzel D (1999) Diagnostic in normal pressure hydrocephalus: A mathematical model for determination of the ICP-dependent resistance and compliance. Acta Neurochir (Wien) 141:941–947; discussion 947–948
56.
Momjian S, Czosnyka Z, Czosnyka M, Pickard JD (2004) Link between vasogenic waves of intracranial pressure and cerebrospinal fluid outflow resistance in normal pressure hydrocephalus. Br J Neurosurg 18:56–61CrossRef
57.
Momjian S, Owler BK, Czosnyka Z, Czosnyka M, Pena A, Pickard JD (2004) Pattern of white matter regional cerebral blood flow and autoregulation in normal pressure hydrocephalus. Brain 127:965–972CrossRef
58.
Piper I, Dunn L, Contant C, Yau Y, Whittle I, Citerio G, Kiening K, Schvning W, Ng S, Poon W, Enblad P, Nilsson P (2000) Multi-centre assessment of the Spiegelberg compliance monitor: preliminary results. Acta Neurochir Suppl 76:491–494
59.
Shapiro K, Marmarou A, Conway E (1983) Comparison of bolus and constant infusion techniques for determining the resistance of the absorption of CSF. In: Ishii S, Nagai H, Brock M (eds) Intracranial pressure V, Springer, Heidelberg
60.
Smielewski P, Czosnyka M, Roszkowski M, Walencik A (1995) Identification of the cerebrospinal compensatory mechanisms via computer-controlled drainage of the cerebrospinal fluid. Childs Nerv Syst 11:297–300CrossRef
61.
Stephensen H, Andersson N, Eklund A, Malm J, Tisell M, Wikkelso C (2005) Objective B wave analysis in 55 patients with non-communicating and communicating hydrocephalus. J Neurol Neurosurg Psychiatry 76:965–970CrossRef
62.
Sullivan HG, Miller JD, Griffith RL 3rd, Carter W Jr, Rucker S (1979) Bolous versus steady-state infusion for determination of CSF outflow resistance. Ann Neurol 5:228–238CrossRef
63.
Takeuchi T, Kasahara E, Iwasaki M, Mima T, Mori K (2000) Indications for shunting in patients with idiopathic normal pressure hydrocephalus presenting with dementia and brain atrophy (atypical idiopathic normal pressure hydrocephalus). Neurol Med Chir (Tokyo) 40, 38–46; discussion 46–47
64.
Tans JT, Poortvliet DC (1985) CSF outflow resistance and pressure–volume index determined by steady-state and bolus infusions. Clin Neurol Neurosurg 87:159–165CrossRef
65.
Taylor R, Czosnyka Z, Czosnyka M, Pickard JD (2002) A laboratory model of testing shunt performance after implantation. Br J Neurosurg 16:30–35CrossRef
66.
Tsunoda A, Mitsuoka H, Bandai H, Endo T, Arai H, Sato K (2002) Intracranial cerebrospinal fluid measurement studies in suspected idiopathic normal pressure hydrocephalus, secondary normal pressure hydrocephalus, and brain atrophy. J Neurol Neurosurg Psychiatry 73:552–555CrossRef
67.
Tullberg M, Mansson JE, Fredman P, Lekman A, Blennow K, Ekman R, Rosengren LE, Tisell M, Wikkelso C (2000) CSF sulfatide distinguishes between normal pressure hydrocephalus and subcortical arteriosclerotic encephalopathy. J Neurol Neurosurg Psychiatry 69:74–81CrossRef
68.
Vanneste J, Van Acker R (1990) Normal pressure hydrocephalus: did publications alter management? J Neurol Neurosurg Psychiatry 53:564–568CrossRef
69.
Vanneste JA (2000) Diagnosis and management of normal-pressure hydrocephalus. J Neurol 247:5–14CrossRef
70.
Weller RO, Nicoll JA (2003) Cerebral amyloid angiopathy: pathogenesis and effects on the ageing and Alzheimer brain. Neurol Res 25:611–616CrossRef
71.
Wikkelso C, Andersson H, Blomstrand C, Lindqvist G, Svendsen P (1986) Normal pressure hydrocephalus. Predictive value of the cerebrospinal fluid tap-test. Acta Neurol Scand 73:566–573
72.
Williams MA, Razumovsky AY, Hanley DF (1998) Evaluation of shunt function in patients who are never better, or better than worse after shunt surgery for NPH. Acta Neurochir Suppl 71:368–370
Metadaten
Titel
Assessment of cerebrospinal fluid outflow resistance
verfasst von
Anders Eklund
Peter Smielewski
Iain Chambers
Noam Alperin
Jan Malm
Marek Czosnyka
Anthony Marmarou
Publikationsdatum
01.08.2007
Verlag
Springer-Verlag
Erschienen in
Medical & Biological Engineering & Computing / Ausgabe 8/2007
Print ISSN: 0140-0118
Elektronische ISSN: 1741-0444
DOI
https://doi.org/10.1007/s11517-007-0199-5

Weitere Artikel der Ausgabe 8/2007

Medical & Biological Engineering & Computing 8/2007 Zur Ausgabe

Original Article

Microbubbling by co-axial electrohydrodynamic atomization

Original Article

Mixed-phase modeling in snore sound analysis

Original Article

Simulation of an anterior spine instrumentation in adolescent idiopathic scoliosis using a flexible multi-body model

Original Article

Effects of head size and morphology on dynamic responses to impact loading

Original Article

A newly developed tool for intra-tracheal temperature and humidity assessment in laryngectomized individuals: the Airway Climate Explorer (ACE)

Original Article

Classification of breast masses via nonlinear transformation of features based on a kernel matrix

Premium Partner

    Bildnachweise