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Measurement Techniques
Published in: Measurement Techniques 5/2023

08-09-2023 | MEDICAL AND BIOLOGICAL MEASUREMENTS

Assessment of the Possibility of Using Particles of Aerodisperse System for Dynamic Aerosol Lung Scintigraphy

Authors: V. I. Kobylyansky, T. V. Kudasheva, M. G. Berezkina, T. M. Magomedov, D. I. Belenkii, O. B. Chechetkina

Published in: Measurement Techniques | Issue 5/2023

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Abstract

The article considers the use of albumin macroaggregates as a carrier marker (99mTc) for studying the leading protective mechanisms of the respiratory organs: the processes of inhaled substances deposition in the lungs and their removal from the lungs (mucociliary clearance). Albumin macroaggregates are intended for introduction into the respiratory tract by inhalation for dynamic lung scintigraphy. However, their aerodynamic properties, on which the possibility and expediency of such a targeted use depend, have not been studied. To study the aerodynamic properties of albumin macroaggregates and to determine the possibilities of their use in aerosol form for dynamic lung scintigraphy, the processes of inhaled substances deposition and mucociliary clearance were assessed. An aerosol from a suspension of albumin macroaggregates in distilled water was generated by an ultrasonic inhaler. The dispersity of the generated aerosol was studied by laser spectrometry. The protein content in the initial suspension and dispersible aerosol was determined by the immunochemical method. The shape and morphology of the particles were studied using scanning electron microscopy. The dynamic study of the suspension revealed that its particles are involved in the aerosol generated from the suspension. The dispersion of the latter (approximately 5 μm on average) slightly depends on the radiopharmaceutical concentration and does not depend on the dispersion intensity and air flow rate (in their extreme parameters (minimum/maximum)) specified by the inhaler. It has been shown that the morphology of suspended albumin macroaggregates particles is characterized by a complex shape and roughness. It has been established that the aerodynamic characteristics of the studied albumin macroaggregates are not optimal for studying the processes of deposition and mucociliary clearance. Thus, a final conclusion on the possibilities of using albumin macroaggregates for this purpose requires a direct assessment of the deposition of inhaled radioaerosol generated from this pharmaceutical.
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Metadata
Title
Assessment of the Possibility of Using Particles of Aerodisperse System for Dynamic Aerosol Lung Scintigraphy
Authors
V. I. Kobylyansky
T. V. Kudasheva
M. G. Berezkina
T. M. Magomedov
D. I. Belenkii
O. B. Chechetkina
Publication date
08-09-2023
Publisher
Springer US
Published in
Measurement Techniques / Issue 5/2023
Print ISSN: 0543-1972
Electronic ISSN: 1573-8906
DOI
https://doi.org/10.1007/s11018-023-02235-4

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