Skip to main content
Disciplines
Automotive Business IT + Informatics Construction + Real Estate Electrical Engineering + Electronics Energy + Sustainability Insurance + Risk Finance + Banking Management + Leadership Marketing + Sales Mechanical Engineering + Materials
Events
DE
EN
Books
Journals
Topic Page
Marketing
Start single access now
Access for companies
EXTENDED SEARCH
Log in
Top
Published in:
Amplification and Sequence Analysis of TPI Gene, a Structural Gene of Operon from Lactobacillus delbrueckii Read chapter Read first chapter

2015 | OriginalPaper | Chapter

9. Association of BDNF Levels and Muscoskeletal Problems in Type 2 Diabetes

Authors : Allam Appa Rao, Amit Kumar, Surendra Babu, Anuradha Parihar, Subha Senkhula

Published in: Biotechnology and Bioforensics

Publisher: Springer Singapore

Log in

Activate our intelligent search to find suitable subject content or patents.

search-config
loading …

Abstract

Brain Derived neurotrophic factor (BDNF) is very well reported in development of neurons and it plays major role in memory and interpretation. It is evident that BDNF is involved in maintaining the equilibrium of body weight and glucose homeostasis mechanism. Out of 96 Subjects included in this study Plasma BDNF level was found low in the patients with Type 2 Diabetes. We didn’t find positive indications wrt association of BDNF G196A (Val66Met) polymorphism in diabetes or obesity. Type 2 Diabetic patients with the complaint of Joint pains were found to have even lower Plasma BDNF levels as compared to the diabetic patients without any Neurological problems or joint pains. Worsening BDNF Levels may be an alarming factor for type 2 diabetic patients with respect to development of Neurological disorders.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

inform now
previous chapter Rapid Diagnostic Tests Show False Positive Leading to Dilemma in Malarial Treatment: A Case Study
Footnotes
1
Present study was approved by the Institutional Ethical Committee for Research on Human volunteers, Andhra University Visakhapatnam.
 
Literature
1.
Molteni R, Barnard RJ, Ying Z et al (2002) A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning. Neuroscience 112:803–814CrossRef
2.
Bath KG, Lee FS (2010) Neurotrophic factor control of adult SVZ neurogenesis. Dev Neurobiol 70(5):339–349 Special Issue: Trophic factors: 50 years of growth
3.
Mattson MP, Maudsley S, Martin B (2004) BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends Neurosci 27:589–594CrossRef
4.
Matthews VB, Åström M-B, Chan MHS, Bruce CR, Prelovsek O, Åkerström T, Yfanti C, Broholm C, Mortensen OH, Penkowa M, Hojman P, Zankari A, Watt MJ, Pedersen BK, Febbraio MA (2009) Brain derived neutrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMPK. Diabetologia 52:1409–1418CrossRef
5.
Kernie Steven G, Liebl Daniel J, Parada Luis F (2000) BDNF regulates eating behavior and locomotor activity in mice. EMBO J 19:1290–1300CrossRef
6.
Causing CG, Gloster A, Aloyz R, Bamji SX, Chang E, Fawcett J, Kutchel G, Miler FD (1997) Synaptic innervation density is regulated by neuronderived, BDNF. Neuron 18:257–267CrossRef
7.
Rozen Steve, Skaletsky Helen J (2000) Primer3 on the www for general users and for biologist programmers. In: Krawetz S, Misener S (eds) Bioinformatics methods and protocols: methods in molecular biology. Humana Press, Totowa, pp 365–386
8.
Ono M, Ichihara J, Nonomura T et al (1997) Brain-derived neurotrophic factor reduces blood glucose level in obese diabetic mice but not in normal mice. Biochem Biophys Res Commun 238:633–637CrossRef
9.
Krabbe KS, Nielsen AR, Krogh-Madsen R et al (2007) Brain-derived neurotrophic factor (BDNF) and type 2 diabetes. Diabetologia 50(2):431–438CrossRef
10.
Figurov A, Pozzo-Miller LD, Olafsson P, Wang T, Lu B (1996) Regulation of synaptic responses to high-frequency stimulation and LTP by neurotropins in the hippocampus. Nature 381:706–709CrossRef
11.
Lommatzsch M, Zingler D, Schuhbaeck K et al (2005) The impact of age, weight and gender on BDNF levels in human platelets and plasma. Neurobiol Aging 26(1):115–123CrossRef
12.
Li Y, Rowland C, Tacey K et al (2005) The BDNF Val66Met polymorphism is not associated with late onset Alzheimer’s disease in three case-control samples. Mol Psychiatry 10(809–810):26
13.
Surtees PG, Wainwright NWJ, Willis-Owen SAG et al (2007) No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adults. J Psychiatr Res 41(5):404–409
14.
Matsushita S, Arai H, Matsui T et al (2005) Brain-derived neurotrophic factor gene polymorphisms and Alzheimer’s disease. J Neural Transm 112:703–711CrossRef
15.
Maggio R, Riva M, Vaglini F, Fornai F, Racagni G, Corsini GU (1997) Striatal increase of neurotrophic factors as a mechanism of nicotine protection in experimental Parkinsonism. J Neural Transm 104:1113–1123CrossRef
16.
Kim RP, Edelman SV, Kim DD (2001) Musculoskeletal complications of diabetes. Clin Diab 19(3):132–135CrossRef
Metadata
Title
Association of BDNF Levels and Muscoskeletal Problems in Type 2 Diabetes
Authors
Allam Appa Rao
Amit Kumar
Surendra Babu
Anuradha Parihar
Subha Senkhula
Copyright Year
2015
Publisher
Springer Singapore
Book
Biotechnology and Bioforensics

Print ISBN: 978-981-287-049-0

Electronic ISBN: 978-981-287-050-6

Copyright Year: 2015

DOI
https://doi.org/10.1007/978-981-287-050-6_9

Premium Partners

    Image Credits