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Polymer Bulletin
Published in: Polymer Bulletin 10/2023

21-11-2022 | Original Paper

Bioactive films for the control of skin pathogens with sophorolipids from Starmerella bombicola

Authors: Giovanna Amaral Filipe, Victoria Akemi Itakura Silveira, Marcelly Chue Gonçalves, Rayanne R. Beltrame Machado, Celso Vataro Nakamura, Cristiani Baldo, Suzana Mali, Renata Katsuko Takayama Kobayashi, Maria Antonia P. Colabone Celligoi

Published in: Polymer Bulletin | Issue 10/2023

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Abstract

Cutaneous infections involve microbial invasion of pathogens into the skin layers and can lead to mild cases and severe life-threatening conditions. Biopolymeric films could be used to treat cutaneous infections and also meet the demand of the consumers for new biological-based products obtained from renewable sources. Sophorolipids are antimicrobial biosurfactants produced by the yeast Starmerella bombicola with great potential for application by pharmaceutical and cosmetic industries. The aim of this study was to produce and to characterize biodegradable films based on cassava starch, pullulan and sophorolipids for the control of skin pathogens, with and without the presence of citric acid as a crosslinking agent. Films were obtained by the casting method, and eight formulations were prepared using different concentrations of sophorolipids (0, 2.5, 5.0 and 10.0%-g/100 g polymer), with and without citric acid. The results showed that the addition of sophorolipids resulted in more opaque surfaces, forming homogeneous structures observed by scanning electron microscopy. Addition of citric acid resulted in films with higher flexibility, lower solubility and water vapor permeability values. The films containing sophorolipids in all concentrations were able to inhibit 100% of the growth of Staphylococcus aureus and Staphylococcus epidermidis. These findings lead to the possibility of developing new, sustainable, and natural antimicrobial sophorolipid films to treat bacterial skin infections.
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Metadata
Title
Bioactive films for the control of skin pathogens with sophorolipids from Starmerella bombicola
Authors
Giovanna Amaral Filipe
Victoria Akemi Itakura Silveira
Marcelly Chue Gonçalves
Rayanne R. Beltrame Machado
Celso Vataro Nakamura
Cristiani Baldo
Suzana Mali
Renata Katsuko Takayama Kobayashi
Maria Antonia P. Colabone Celligoi
Publication date
21-11-2022
Publisher
Springer Berlin Heidelberg
Published in
Polymer Bulletin / Issue 10/2023
Print ISSN: 0170-0839
Electronic ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-022-04575-7

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