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08-06-2023 | ORIGINAL PAPER

Biocompatibility evaluation of nano-hydroxyapatite modified hydroxypropyl methylcellulose/polyvinylpyrrolidone blends

Authors: Archa Unni, Mekha Mariam Mathew, Monisha Manathanath, Sunil Jacob, Pooja Sankaranarayanan, Suchithra Tharamel Vasu, Unnikrishnan Gopalakrishna Panicker

Published in: Polymer Bulletin | Issue 4/2024

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Abstract

Blending of polymers can be utilized to improve the properties of the new hybrid system without sacrificing the individual characteristics of the components. A combination of biocompatible cellulose-based polymer, hydroxypropyl methylcellulose (HPMC) and synthetic biocompatible polymer polyvinyl pyrrolidone (PVP) has been designed to modify the mechanical and thermal properties via blending strategy. This work investigates the modification of HPMC and PVP blends through plasticizing with polyethylene glycol (PEG 6000, a non-toxic plasticizer to improve the flexibility of the matrix. The optimized blend system has been embedding with nHA as a biocompatible multifunctional filler to reinforce the polymer matrix for improving the efficacy in biomedical applications. The characterization has been extended through the evaluation of FTIR, XRD, TGA, DSC, SEM and UV-Visible spectroscopy. The reinforced blend has been found to match the requirements for fabricating wound healing patches in the biosector.

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Title: Biocompatibility evaluation of nano-hydroxyapatite modified hydroxypropyl methylcellulose/polyvinylpyrrolidone blends
Authors: Archa Unni
Mekha Mariam Mathew
Monisha Manathanath
Sunil Jacob
Pooja Sankaranarayanan
Suchithra Tharamel Vasu
Unnikrishnan Gopalakrishna Panicker
Publication date: 08-06-2023
Publisher: Springer Berlin Heidelberg
Published in: Polymer Bulletin / Issue 4/2024
Print ISSN: 0170-0839
Electronic ISSN: 1436-2449
DOI: https://doi.org/10.1007/s00289-023-04870-x

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