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Biomass Conversion and Biorefinery

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01-07-2022 | Original Article

Biological potential and bio-refinery from marine macro algae Caulerpa scalpelliformis

Author: Palaniappan Seedevi

Published in: Biomass Conversion and Biorefinery | Issue 7/2024

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Abstract

The present investigation evaluated the toxic effect and bioactive potential of marine macro algae Caulerpa scalpelliformis. The crude methanolic extract was fractionated in diethylaminoethyl (DEAE) cellulose column chromatography using NaCl (0.1–10 M). The fractions were dialyzed and freeze-dried. The active fractions (F1, F2, and F3) were obtained using TLC chromatography. The crude methanolic extract and fractions showed strong hemolytic activity of 129.55, 73.73, 43.47, and 37.73 HT/mg in chicken blood, respectively, the human blood group (AB and O) showed considerable hemolytic activity of 73.73, 43.47, and 37.73 HT/mg, respectively, and the fraction (F3) had no activity. The acute toxic effect of the crude methanolic extract and fractions (F1, F2, and F3) showed the lethal dose (LD₅₀) at 176, 121.5, 138, and 152 mg/kg body weight. The crude methanolic extract and fractions indicated strong analgesic activity at the ratio of 0.26, 0.37, 0.11, and 0.10 using the tail flick test in mice at 12.5 mg/kg body weight. These results suggest that the methanolic extract and its fractions from C. scalpelliformis may be potential pharmacological agents.

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Title: Biological potential and bio-refinery from marine macro algae Caulerpa scalpelliformis
Author: Palaniappan Seedevi
Publication date: 01-07-2022
Publisher: Springer Berlin Heidelberg
Published in: Biomass Conversion and Biorefinery / Issue 7/2024
Print ISSN: 2190-6815
Electronic ISSN: 2190-6823
DOI: https://doi.org/10.1007/s13399-022-02908-0

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