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Journal of Nanoparticle Research

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01-05-2021 | Research paper

Biotin-modified oligochitosan-F127 micelles for honokiol’s encapsulation

Authors: Li Zhu, Zhimei Song, Sijia Feng, Hongmei Xu, Shiyu Chen, Runliang Feng

Published in: Journal of Nanoparticle Research | Issue 5/2021

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Abstract

In the study, biotin-modified oligochitosan-F127 conjugate (F127-CS-BIO) was synthesized as a carrier to prepare honokiol-loaded micelles via dialysis method. The encapsulation efficiency and drug loading were 70.79 ± 2.70% and 9.70 ± 0.57%, respectively. The mean particle size and zeta potentials were 210.9 ± 4.65 nm and 12.9 ± 7.22 mV, respectively. In vitro release studies showed that the release of honokiol from the micelles was slow and steady. MTT evaluation and cellular uptake results demonstrated that F127-CS-BIO was more easily absorbed by tumor cells and resulted in low IC₅₀ value of honokiol due to biotin’s targeting guidance when compared with biotin-unmodified F127-CS. In conclusion, F127-CS-BIO polymer was expected as an effective nanocarrier to encapsulate chemotherapeutic drugs.

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Title: Biotin-modified oligochitosan-F127 micelles for honokiol’s encapsulation
Authors: Li Zhu
Zhimei Song
Sijia Feng
Hongmei Xu
Shiyu Chen
Runliang Feng
Publication date: 01-05-2021
Publisher: Springer Netherlands
Published in: Journal of Nanoparticle Research / Issue 5/2021
Print ISSN: 1388-0764
Electronic ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-021-05229-x

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