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Journal of Nanoparticle Research

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01-05-2015 | Research Paper

Carboxylic acid functionalization of halloysite nanotubes for sustained release of diphenhydramine hydrochloride

Authors: S. Sh. Zargarian, V. Haddadi-Asl, H. Hematpour

Published in: Journal of Nanoparticle Research | Issue 5/2015

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Abstract

Halloysite nanotubes (HNT) (cylindrical shape with external diameter and length in the range of 30–80 nm and 0.2–1 µm, respectively) were functionalized with 3-aminopropyltriethoxysilane (APTES) from hydroxyl groups by a coupling reaction. Subsequently, maleic anhydride was attached to the APTES moieties to yield carboxylic acid-functionalized HNT. Loading and subsequent release of a model drug molecule diphenhydramine hydrochloride (DPH) on modified and unmodified nanotubes were investigated. Morphology of HNT was studied by electron microscopy. Successful attachment of APTES and carboxylic acid groups to halloysite and drug loading were evaluated by Fourier transform infrared spectroscopy. The amount of surface modification and drug adsorption capacity were calculated via thermogravimetric analysis. The ordered crystal structure of loaded drug was evaluated by X-ray diffraction. UV–Visible spectrophotometer was used to study drug release from modified and unmodified samples. Carboxylated halloysite exhibits higher loading capacity and prolonged release of DPH as compared to that of the natural halloysite.

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Title: Carboxylic acid functionalization of halloysite nanotubes for sustained release of diphenhydramine hydrochloride
Authors: S. Sh. Zargarian
V. Haddadi-Asl
H. Hematpour
Publication date: 01-05-2015
Publisher: Springer Netherlands
Published in: Journal of Nanoparticle Research / Issue 5/2015
Print ISSN: 1388-0764
Electronic ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-015-3032-3

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