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Journal of Nanoparticle Research

Erschienen in:

01.05.2015 | Research Paper

Carboxylic acid functionalization of halloysite nanotubes for sustained release of diphenhydramine hydrochloride

verfasst von: S. Sh. Zargarian, V. Haddadi-Asl, H. Hematpour

Erschienen in: Journal of Nanoparticle Research | Ausgabe 5/2015

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Abstract

Halloysite nanotubes (HNT) (cylindrical shape with external diameter and length in the range of 30–80 nm and 0.2–1 µm, respectively) were functionalized with 3-aminopropyltriethoxysilane (APTES) from hydroxyl groups by a coupling reaction. Subsequently, maleic anhydride was attached to the APTES moieties to yield carboxylic acid-functionalized HNT. Loading and subsequent release of a model drug molecule diphenhydramine hydrochloride (DPH) on modified and unmodified nanotubes were investigated. Morphology of HNT was studied by electron microscopy. Successful attachment of APTES and carboxylic acid groups to halloysite and drug loading were evaluated by Fourier transform infrared spectroscopy. The amount of surface modification and drug adsorption capacity were calculated via thermogravimetric analysis. The ordered crystal structure of loaded drug was evaluated by X-ray diffraction. UV–Visible spectrophotometer was used to study drug release from modified and unmodified samples. Carboxylated halloysite exhibits higher loading capacity and prolonged release of DPH as compared to that of the natural halloysite.

Vorheriger Artikel Influence of clay particles on Al2O3 and TiO2 nanoparticles transport and retention through limestone porous media: measurements and mechanisms

Nächster Artikel Stability and phase transfer of catalytically active platinum nanoparticle suspensions

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Titel: Carboxylic acid functionalization of halloysite nanotubes for sustained release of diphenhydramine hydrochloride
verfasst von: S. Sh. Zargarian
V. Haddadi-Asl
H. Hematpour
Publikationsdatum: 01.05.2015
Verlag: Springer Netherlands
Erschienen in: Journal of Nanoparticle Research / Ausgabe 5/2015
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-015-3032-3

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