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2019 | OriginalPaper | Chapter

10. Cellular Defense Mechanisms Following Nanomaterial Exposure: A Focus on Oxidative Stress and Cytotoxicity

Authors : Stephen J. Evans, Gareth J. Jenkins, Shareen H. Doak, Martin J. D. Clift

Published in: Biological Responses to Nanoscale Particles

Publisher: Springer International Publishing

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Abstract

In response to the significant increase in nanotechnology over the last three decades, and the plethora of engineered nanomaterials (ENMs) now becoming available, understanding as to how nano-sized particles may impact upon human health has become a dominating area of research worldwide since the late 1990’s (Stone et al. in Environmental Health Perspectives, 2017) [1]. Whilst approaches constantly adapt to the increasing number and variety of ENMs produced for a plethora of different applications, the quantity of alternative physico-chemical characteristics, a key factor in the potential hazard of ENMs (Bouwmeester et al. in Nanotoxicology 5:1–11, 2011) [2], is further increasing in number and type.

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Stone, V., Miller, M.R., Clift, M.J D., Elder, A., Mills, N.L., Moller, P., Schins, R.P.F., Vogel, U., Kreyling, W.G., Jensen, K.A., Kuhlbusch, T.A.J., Schwarze, P.E., Hoet, P., Pietroiusti, A., De Vizcaya-Ruiz, A., Baeza-Squiban, A., Tran, L., Cassee, F.R.: Nanomaterials vs ambient ultrafine particles: an opportunity to exchange toxicology knowledge. Environ. Health Perspect. (2017) http://dx.doi.org/10.1289/EHP424

Bouwmeester, H., Lynch, I., Marvin, H.J.P., Dawson, K.A., Berges, M., Braguer, D., Byrne, H.J., Casey, A., Chambers, G., Clift, M.J.D., Elia, G., Fernandes, T.F., Fjellsbø, L.B., Hatto, P., Juillerat, L., Klein, C., Kreyling, W.G., Nickel, C., Riediker, M., Stone, V.: Minimal analytical characterisation of engineered nanomaterials needed for hazard assessment in biological matrices. Nanotoxicology 5, 1–11 (2011)

Clift, M.J.D., Gehr, P. Rothen-Rutishauser, B.: In vitro testing for Nanotoxicology: a valid alternative? Arch. Toxicol. 85, 723–731 (2011)

Ferin, J., Oberdorster, G., Penney, D.P.: Pulmonary retention of ultrafine and fine particles in rats. Am. J. Respir. Cell Mol. Biol. 6, 535–542 (1992)

Donaldson, K., Tran, C.L.: An introduction to the short-term toxicology of respirable industrial fibres. Mutat. Res./Fundamen. Mol. Mechan. Mutagen. 553, 5–9 (2004)

Donaldson, K., Murphy, F.A., Duffin, R., Poland, C.A.: Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma. Part Fibre Toxicol. 7, 5 (2010)

Evans, S.J., Clift, M.J., Singh, N., de Oliveira Mallia, J., Burgum, M., Wills, J.W., Wilkinson, T.S., Jenkins, G.J., Doak, S.H.: Critical review of the current and future challenges associated with advanced in vitro systems towards the study of nanoparticle (secondary) genotoxicity. Mutagenesis 4 (2017)

Schins, R.P., Knaapen, A.M.: Genotoxicity of poorly soluble particles. Inhal. Toxicol. 19, 189–198 (2007)

Limbach, L.K., Li, Y., Grass, R.N., Brunner, T.J., Hintermann, M.A., Muller, M., Gunther, D., Stark, W.J.: Oxide nanoparticle uptake in human lung fibroblasts: effects of particle size, agglomeration, and diffusion at low concentrations. Environ. Sci. Technol. 39, 9370–9376 (2005)

10.

Clift, M.J.D., Rothen-Rutishauser, B.: Studying the oxidative stress paradigm in vitro: a theoretical and practical perspective. In: Armstrong D., Bharali, D. (eds.) Oxidative Stress and Nanotechnology vol. 1082, pp. 115–133 (2013)

11.

Poland, C.A., Duffin, R., Kinloch, I., Maynard, A., Wallace, W.A.H., Seaton, A., Stone, V., Brown, S., MacNee, W., Donaldson, K.: Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nat Nanotech 3, 423–428 (2008)

12.

Unfried, K., Albrecht, C., Klotz, L.O., von Mikecz, A., Grether-Beck, S., Schins, R.P.F.: Cellular responses to nanoparticles: target structures and mechanisms. Nanotox 1, 1–20 (2007)

13.

Conner, S.D., Schmid, S.L.: Regulated portals of entry into the cell. Nature 422, 37–44 (2003)

14.

Gamaley, I.A., Klyubin, I.V.: Roles of reactive oxygen species: signaling and regulation of cellular functions. Int. Rev. Cytol. 188, 203–255 (1999)

15.

Cadenas, E., Boveris, A., Ragan, C.I., Stoppani, A.O.M.: Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria. Arch. Biochem. Biophys. 180, 248–257 (1977)

16.

Poljsak, B., Šuput, D., Milisav, I.: Achieving the balance between ROS and antioxidants: when to use the synthetic antioxidants. Oxid. Med. Cell. Longev 11 (2013)

17.

Circu, M.L., Aw, T.Y.: Reactive oxygen species, cellular redox systems and apoptosis. Free Radic. Biol. Med. 48, 749–762 (2010)

18.

Burton, G.J., Jauniaux, E.: Oxidative stress. Best Pract. Res. Clin. Obstet. Gynaecol. 25, 287–299 (2011)

19.

Zhang, J., Wang, X., Vikash, V., Ye, Q., Wu, D., Liu, Y., Dong, W.: ROS and ROS-mediated cellular signaling. Oxid. Med. Cell. Longev. 2016, 18 (2016)

20.

Vasilaki, A.T., McMillan, D.C.: Lipid peroxidation. In: Schwab, M. (ed.) Encyclopedia of Cancer. Springer, Berlin, Heidelberg (2011)

21.

Manke, A., Wang, L., Rojanasakul, Y.: Mechanisms of nanoparticle-induced oxidative stress and toxicity. Biomed. Res. Int. 2013, 15 (2013)

22.

Dalle-Donne, I., Rossi, R., Giustarini, D., Milzani, A., Colombo, R.: Protein carbonyl groups as biomarkers of oxidative stress. Clin. Chim. Acta 329, 23–38 (2003)

23.

Singh, N., Manshian, B., Jenkins, G.J., Griffiths, S.M., Williams, P.M., Maffeis, T.G., Wright, C.J., Doak, S.H.: NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials. Biomaterials 30, 3891–3914 (2009)

24.

Valko, M., Izakovic, M., Mazur, M., Rhodes, C., Telser, J.: Role of oxygen radicals in DNA damage and cancer incidence. Mol. Cell Biochem. 266 (2004)

25.

Valko, M., Rhodes, C.J., Moncol, J., Izakovic, M., Mazur, M.: Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem. Biol. Interact. 160, 1–40 (2006)

26.

Cooke, M., Evans, M., Dizdrogla, M., Lunec, J.: Oxidative DNA damage: mechanisms, mutation, and disease. FASEB J. 17 (2003)

27.

Perreault, F., Pedroso Melegari, S., Henning da Costa, C., de Oliveira Franco Rossetto, A.L., Popovic, R., Gerson Matias, W.: Genotoxic effects of copper oxide nanoparticles in Neuro 2A cell cultures. Sci. Total Environ. 441, 117–124 (2012)

28.

Siddiqi, N.J., Abdelhalim, M.A.K., El-Ansary, A.K., Alhomida, A.S., Ong, W.: Identification of potential biomarkers of gold nanoparticle toxicity in rat brains. J. Neuroinflamm. 9, 1 (2012)

29.

Foldbjerg, R., Dang, D.A., Autrup, H.: Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549. Arch. Toxicol. 85, 743–750 (2011)

30.

Kim, S., Choi, J.E., Choi, J., Chung, K.H., Park, K., Yi, J., Ryu, D.Y.: Oxidative stress-dependent toxicity of silver nanoparticles in human hepatoma cells. Toxicol. In Vitro 23, 1076–1084 (2009)

31.

Magdolenova, Z., Collins, A., Kumar, A., Dhawan, A., Stone, V., Dusinska, M.: Mechanisms of genotoxicity. A review of in vitro and in vivo studies with engineered nanoparticles. Nanotoxicology 8, 233–278 (2014)

32.

Huang, Y.-W., Wu, C.-H., Aronstam, R.S.: Toxicity of transition metal oxide nanoparticles: recent insights from in vitro studies. Materials 3, 4842 (2010)ADS

33.

Abdal dayem, A., Hossain, M.K., Lee, S.B., Kim, K., Saha, S.K., Yang, G.-M., Choi, H.Y., Cho, S.-G.: The role of reactive oxygen species (ros) in the biological activities of metallic nanoparticles. Int. J. Mol. Sci. 18, 120 (2017)

34.

Sun, S., Wang, Q., Giang, A., Cheng, C., Soo, C., Wang, C.-Y., Liau, L., Chiu, R.: Knockdown of CypA inhibits interleukin-8 (IL-8) and IL-8-mediated proliferation and tumor growth of glioblastoma cells through down-regulated NF-kB. J. Neurooncol. 101 (2011)

35.

Trouiller, B., Reliene, R., Westbrook, A., Solaimani, P., Schiestl, R.H.: Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice. Can. Res. 69, 8784–8789 (2009)

36.

Tulinska, J., Kazimirova, A., Kuricova, M., Barancokova, M., Liskova, A., Neubauerova, E., Drlickova, M., Ciampor, F., Vavra, I., Bilanicova, D., Pojana, G., Staruchova, M., Horvathova, M., Jahnova, E., Volkovova, K., Bartusova, M., Cagalinec, M., Dusinska, M.: Immunotoxicity and genotoxicity testing of PLGA-PEO nanoparticles in human blood cell model. Nanotoxicology 1, 33–43 (2015)

37.

Kaminskyy, V.O., Zhivotovsky, B.: Free radicals in cross talk between autophagy and apoptosis. Antioxid. Redox. Signal. 21, 86–102 (2014)

38.

Redza-Dutordoir, M., Averill-Bates, D.A.: Activation of apoptosis signalling pathways by reactive oxygen species. Biochimica et Biophysica Acta (BBA)—Mol. Cell Res. 1863, 2977–2992 (2016)

39.

Vandenabeele, P., Galluzzi, L., Berghe, T.V., Kroemer, G.: Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat. Rev. Mol. Cell Biol. 11, 700 (2010)

Title: Cellular Defense Mechanisms Following Nanomaterial Exposure: A Focus on Oxidative Stress and Cytotoxicity
Authors: Stephen J. Evans
Gareth J. Jenkins
Shareen H. Doak
Martin J. D. Clift
Publisher: Springer International Publishing
Book: Biological Responses to Nanoscale Particles
Print ISBN: 978-3-030-12460-1

Electronic ISBN: 978-3-030-12461-8

Copyright Year: 2019
DOI: https://doi.org/10.1007/978-3-030-12461-8_10

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