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Journal of Nanoparticle Research

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01-10-2018 | Research Paper

Characterization of aerosols generated from nine nanomaterial powders: reliability with regard to in vivo inhalation toxicology studies

Authors: Sébastien Bau, Soleiman Bourrous, François Gaie-Levrel, Olivier Witschger

Published in: Journal of Nanoparticle Research | Issue 10/2018

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Abstract

In experimental toxicology, when simulating human exposure to aerosols in the working environment, inhalation is the route of administration of choice for evaluating the toxicity of a given material (in aerosol form) in animals. In this context, this work aimed to contribute to the establishment of recommendations concerning the characterization of aerosol tests in inhalation toxicology studies. In particular, the work consisted of experimentally characterizing test aerosols using a given generation method to be used for inhalation toxicology studies. Nine nanomaterial powders have been investigated (four types of TiO₂, two types of SiO₂, ZnO, CeO, and BaSO₄). The aerosols produced cover the particle size range from a few tens of nanometers up to several micrometers and are mainly composed of aggregates and/or agglomerates. The work carried out shows that generation and characterization of test aerosols for inhalation toxicology studies is a complex but essential element of inhalation studies, for which the conditions required (stability, repeatability, level of concentration) are sometimes difficult to obtain. Moreover, this study highlights the necessity to carry out preliminary tests to ascertain the performances of the chosen devices and their suitability for inhalation toxicology.

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Adamcakova-Dodd A, Stebounova LV, O’Shaughnessy PT, Kim JS, Grassian VH, Thorne PS (2012) Murine pulmonary responses after sub-chronic exposure to aluminum oxide-based nanowhiskers. Part Fiber Toxicol 9:22. https://doi.org/10.1186/1743-8977-9-22 CrossRef

Asgharian B et al. (2009) Multiple-path particle dosimetry model (MPPD v 2.11): a model for human and rat airway particle dosimetry: Hamner Institutes for Health Sciences Applied Research Associates (ARA), National Institute for Public Health and the Environment (RIVM), and Ministry of Housing, Spatial Planning and the Environment, Editor. Raleigh, North Carolina, USA: Applied Research Associates (ARA)

Asgharian B, Price OT, Oldham M, Chen LC, Saunders EL, Gordon T, Mikheev VB, Minard KR, Teeguarden JG (2014) Computational modeling of nanoscale and microscale particle deposition, retention and dosimetry in the mouse respiratory tract. Inhal Toxicol 26:829–842. https://doi.org/10.3109/08958378.2014.935535 CrossRef

Baker GL, Gupta A, Clark ML, Valenzuela BR, Staska LM, Harbo SJ, Pierce JT, Dill JA (2008) Inhalation toxicity and lung toxicokinetics of C60 fullerene nanoparticles and microparticles. Toxicol Sci 101:122–131. https://doi.org/10.1093/toxsci/kfm243 CrossRef

Bermudez E, Mangum JB, Wong BA, Asgharian B, Hext PM, Warheit DB, Everital JI (2004) Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles. Toxicol Sci 77:347–357CrossRef

Brown JS, Wilson WE, Grant LD (2005) Dosimetric comparisons of particle deposition and retention in rats and humans. Inhal Toxicol 17:355–385. https://doi.org/10.1080/08958370590929475 CrossRef

Buckley A, Hodgson A, Warren J, Guo C, Smith R (2016) Size-dependent deposition of inhaled nanoparticles in the rat respiratory tract using a new nose-only exposure system. Aerosol Sci Technol 50:1–10. https://doi.org/10.1080/02786826.2015.1124987 CrossRef

CEN (2013) TS 16450:2013 Ambient air. Automated measuring systems for the measurement of the concentration of particulate matter (PM₁₀; PM_2,5)

Charvet A, Bau S, Paez-Coy NE, Bémer D, Thomas D (2014) Characterizing the effective density and primary particle diameter of airborne nanoparticles produced by spark discharge using mobility and mass measurements (tandem DMA/APM). J Nanopart Res 16:2418CrossRef

Cosnier F, Bau S, Grossmann S, Nunge H, Brochard C, Viton S, Payet R, Witschger O, Gaté L (2016) Design and characterization of an inhalation system to expose rodents to nanoaerosols. Aerosol Air Qual Res 16:2989–3000. https://doi.org/10.4209/aaqr.2016.01.0034 CrossRef

De Carlo PF, Slowik JG, Wornsop DR, Davidovits P, Jimenez JL (2004) Particle morphology and density characterization by combined mobility and aerodynamic diameter measurements. Part 1: theory. Aerosol Sci Technol 38:1185–1205CrossRef

Elder A, Gelein R, Finkelstein JN, Driscoll KE, Harkema J, Gn O (2005) Effects of subchronically inhaled carbon black in three species. I. Retention kinetics, lung inflammation, and histopathology. Toxicol Sci 88:614–629. https://doi.org/10.1093/toxsci/kfi327 CrossRef

Ellinger-Ziegelbauer H, Pauluhn J (2009) Pulmonary toxicity of multi-walled carbon nanotubes (Baytubes (R)) relative to alpha-quartz following a single 6 h inhalation exposure of rats and a 3 months post-exposure period. Toxicology 66:16–29CrossRef

Geiser M, Kreyling WG (2010) Deposition and biokinetics of inhaled nanoparticles. Part Fiber Toxicol 7:2. https://doi.org/10.1186/1743-8977-7-2 CrossRef

ICRP (1994) Publication 66: Human respiratory tract model for radiological protection:Oxford: Pergamon

ISO (2009) 15767. Workplace atmospheres—controlling and characterizing uncertainty in weighing collected aerosols

ISO (2012) TR 13014. Nanotechnologies—Guidance on physico-chemical characterization of engineered nanoscale materials for toxicologic assessment

Jung H, Mulholland GW, Pui DYH, Kim JH (2012) Re-evaluation of the slip correction parameter of certified PSL spheres using a nanometer differential mobility analyzer (NDMA). J Aerosol Sci 51:24–34. https://doi.org/10.1016/j.jaerosci.2012.04.005 CrossRef

Li J-G, Li WX, Xu JY, Cai XQ, Liu RL, Li YJ, Zhao QF, Li QN (2007) Comparative study of pathological lesions induced by multiwalled carbon nanotubes in lungs of mice by intratracheal instillation and inhalation. Environ Toxicol 22:415–421. https://doi.org/10.1002/tox.20270 CrossRef

Ma-Hock L, Treumann S, Strauss V, Brill S, Luizi F, Mertler M, Wiench K, Gamer AO, van Ravenzwaay B, Landsiedel R (2009) Inhalation toxicity of multiwall carbon nanotubes in rats exposed for 3 months. Toxicol Sci 112:468–481. https://doi.org/10.1093/toxsci/kfp146 CrossRef

Ma-Hock L, Strauss V, Treumann S, Küttler K, Wohlleben W, Hofmann T, Gröters S, Wiench K, van Ravenzwaay B, Landsiedel R (2013) Comparative inhalation toxicity of multi-wall carbon nanotubes, graphene, graphite nanoplatelets and low surface carbon black. Part Fiber Toxicol 10:23. https://doi.org/10.1186/1743-8977-10-23 CrossRef

Mercer RR, Scabilloni JF, Hubbs AF, Wang L, Battelli LA, McKinney W, Castranova V, Porter DW (2013) Extrapulmonary transport of MWCNT following inhalation exposure. Part Fiber Toxicol 10:38. https://doi.org/10.1186/1743-8977-10-38 CrossRef

Morimoto Y, Horie M, Kobayashi N, Shinohara N, Shimada M (2012) Inhalation toxicity assessment of carbon-based nanoparticles. Acc Chem Res 46:770–781CrossRef

Noël A, Cloutier Y, Wilkinson KJ, Dion C, Hallé S, Maghni K, Tardif R, Truchon G (2013) Generating nano-aerosols from TiO₂ (5 nm) nanoparticles showing different agglomeration states. Application to toxicological studies. J Occup Environ Hyg 10:86–96CrossRef

Nurkiewicz TR, Porter DW, Hubbs AF, Cumpston JL, Chen BT, Frazer DG, Castranova V (2008) Nanoparticle inhalation augments particle-dependent systemic microvascular dysfunction. Particle and Fibre. Toxicology 5(1):1. https://doi.org/10.1186/1743-8977-5-1 CrossRef

Oberdörster G, Castranova V, Ashgarian B, Sayre P (2015) Inhalation exposure to carbon nanotubes (CNT) and carbon nanofibers (CNF): methodology and dosimetry. J Toxicol Environ Health B 18:121–212CrossRef

OECD (2012a) Guidance on sample preparation and dosimetry for the safety testing of manufactured nanomaterials ENV/JM/MONO:40

OECD (2012b) Inhalation toxicity testing: expert meeting on potential revisions to OECD test guidelines and guidance document ENV/JM/MONO:14

OECD (2017) OECD guideline for the testing of chemicals - Test No. 412: Subacute. Inhalation Toxicity: 28-Day Study

Oller AR, Oberdörster G (2016) Incorporation of dosimetry in the derivation of reference concentrations for ambient or workplace air: a conceptual approach. J Aerosol Sci 99:40–45. https://doi.org/10.1016/j.jaerosci.2016.01.015 CrossRef

Pauluhn J (2010) Subchronic 13-week inhalation exposure of rats to multiwalled carbon nanotubes: toxic effects are determined by density of agglomerate structures, not fibrillar structures. Toxicol Sci 113:226–242CrossRef

Porter DW et al. (2001) Time course of pulmonary response of rats to inhalation of crystalline silica: histological results and biochemical indices of damage, lipidosis, and fibrosis 20:14 doi:10.1615/. J Environ Pathol Toxicol Oncol. v20.iSuppl.1.10

Porter DW, Hubbs AF, Mercer R, Robinson VA, Ramsey D, McLaurin J, Khan A, Battelli L, Brumbaugh K, Teass A, Castranova V (2004) Progression of lung inflammation and damage in rats after cessation of silica inhalation. Toxicol Sci 79:370–380. https://doi.org/10.1093/toxsci/kfh110 CrossRef

Porter DW, Millecchia LL, Willard P, Robinson VA, Ramsey D, McLaurin J, Khan A, Brumbaugh K, Beighley CM, Teass A, Castranova V (2006) Nitric oxide and reactive oxygen species production causes progressive damage in rats after cessation of silica inhalation. Toxicol Sci 90:188–197. https://doi.org/10.1093/toxsci/kfj075 CrossRef

Porter DW et al. (2012) Acute pulmonary dose-responses to inhaled multi-walled carbon nanotubes. In: Nanotoxicology

Tsai C-J, Lin G-Y, Liu C-N, He C-E, Chen C-W (2012) Characteristic of nanoparticles generated from different nano-powders by using different dispersion methods. J Nanopart Res 14:777. https://doi.org/10.1007/s11051-012-0777-9 CrossRef

Virtanen A, Ristimäki J, Keskinen J (2004) Method for measuring effective density and fractal dimension of aerosol agglomerates. Aerosol Sci Technol 38:437–446CrossRef

Title: Characterization of aerosols generated from nine nanomaterial powders: reliability with regard to in vivo inhalation toxicology studies
Authors: Sébastien Bau
Soleiman Bourrous
François Gaie-Levrel
Olivier Witschger
Publication date: 01-10-2018
Publisher: Springer Netherlands
Published in: Journal of Nanoparticle Research / Issue 10/2018
Print ISSN: 1388-0764
Electronic ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-018-4381-5

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