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Arabian Journal for Science and Engineering
Published in: Arabian Journal for Science and Engineering 1/2022

30-06-2021 | Review-Chemistry

Chromanone-A Prerogative Therapeutic Scaffold: An Overview

Authors: Sonia Kamboj, Randhir Singh

Published in: Arabian Journal for Science and Engineering | Issue 1/2022

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Abstract

Chromanone or Chroman-4-one is the most important and interesting heterobicyclic compound and acts as a building block in medicinal chemistry for isolation, designing and synthesis of novel lead compounds. Structurally, absence of a double bond in chromanone between C-2 and C-3 shows a minor difference from chromone but exhibits significant variations in biological activities. In the present review, various studies published on synthesis, pharmacological evaluation on chroman-4-one analogues are addressed to signify the importance of chromanone as a versatile scaffold exhibiting a wide range of pharmacological activities. But, due to poor yield in the case of chemical synthesis and expensive isolation procedure from natural compounds, more studies are required to provide the most effective and cost-effective methods to synthesize novel chromanone analogs to give leads to chemistry community. Considering the versatility of chromanone, this review is designed to impart comprehensive, critical and authoritative information about chromanone template in drug designing and development.
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Metadata
Title
Chromanone-A Prerogative Therapeutic Scaffold: An Overview
Authors
Sonia Kamboj
Randhir Singh
Publication date
30-06-2021
Publisher
Springer Berlin Heidelberg
Published in
Arabian Journal for Science and Engineering / Issue 1/2022
Print ISSN: 2193-567X
Electronic ISSN: 2191-4281
DOI
https://doi.org/10.1007/s13369-021-05858-3

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